Article
Immunology
Sibel Erguen
Summary: The aim of this study was to determine health sciences students' levels of knowledge about HPV infection and the vaccine and their health beliefs, and to examine the relationship between their knowledge of HPV infection/vaccine and their health beliefs. Results showed that although the students' levels of knowledge about HPV infection and the vaccine were low, they perceived HPV infection to be a severe problem. It was also determined that as the students' knowledge about HPV increased, their health belief levels regarding HPV infection and the vaccine increased as well.
Article
Public, Environmental & Occupational Health
Madan Khatiwada, Cissy Kartasasmita, Henny Suzana Mediani, Christine Delprat, Guido Van Hal, Carine Dochez
Summary: The study found that the majority of Indonesian university students are aware of cervical cancer and HPV, but only a small percentage knew about the HPV vaccine before the study. Despite average knowledge levels on the HPV vaccine, the students demonstrated a strong willingness to receive it, believing in its safety and effectiveness in preventing HPV infection. However, high costs and insufficient information flow have been identified as potential barriers to the adoption of the HPV vaccine in Indonesia.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Marjorie Wright, Vanessa Pazdernik, Corey Luebbering, Joan M. Davis
Summary: The study assessed knowledge and attitudes about HPV and HPV vaccination among dental students of different years. Results showed deficits in HPV-related knowledge and a decreasing willingness to administer the HPV vaccine in future practice among dental students. HPV training improved students' understanding of the burden of HPV disease and the importance of HPV vaccination.
Article
Immunology
Gulzhanat Aimagambetova, Aisha Babi, Torgyn Issa, Alpamys Issanov
Summary: The study found that Kazakhstani women have contrasting attitudes towards the HPV vaccine, with approximately half having positive attitudes and almost half having negative or neutral attitudes. Women with low education levels, high number of children, belief in alternative medicine, and impacted by the failed vaccination program in 2013 are less likely to have a positive attitude towards the vaccine.
Article
Immunology
Gang Chen, Biao Wu, Xuchao Dai, Mengqi Zhang, Yupeng Liu, Hong Huang, Kun Mei, Zhigang Wu
Summary: This study investigated the awareness and willingness to receive HPV vaccination among college students in Wenzhou. The findings showed that male students had lower awareness and willingness compared to females. Price, safety concerns, and lack of knowledge were identified as major barriers to HPV vaccination.
Article
Public, Environmental & Occupational Health
Michele Sorrentino, Michelangelo Mercogliano, Federica Esposito, Agostina Maria Lamberti, Gaetano Buonocore, Carla Riganti, Maria Triassi, Raffaele Palladino
Summary: This study assesses the HPV vaccination uptake and its correlates among medical students and identifies barriers, knowledge, and attitudes towards HPV vaccination. The findings suggest that an active and up-to-date call strategy and extending the free-of-charge offer are essential measures to improve vaccination uptake.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biotechnology & Applied Microbiology
Tsegaw Biyazin, Ashenafi Yilma, Aynalem Yetwale, Belete Fenta, Yalemtsehay Dagnaw
Summary: The study aimed to investigate knowledge and attitudes towards HPV vaccination among female high-school students. The results showed that overall knowledge and attitude towards HPV vaccination were low, and factors such as parents' educational status, participation in school media activities, and smartphone ownership were significantly associated with knowledge. The study suggests a collaborative effort to enhance knowledge and attitudes towards HPV vaccination among female students.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Yu Ma, Cuixiu Wang, Fanghua Liu, Guixiong Lian, Shuxue Li, Qing He, Tiegang Li
Summary: Data collected from college students in Guangzhou, China showed a low HPV vaccine coverage rate of approximately 3.09%, with 55.57% of participants expressing hesitation towards vaccination. Factors influencing vaccination included urban residence, high monthly consumption, awareness of vaccination adaptive population, knowledge of infection-related risk factors, and belief in the effectiveness of the HPV vaccine. Further efforts, such as establishing national financial subsidies and enhancing health education, are needed to increase the vaccination rate in China.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Sayyed Fawad Ali Shah, Tamar Ginossar, Joshua M. Bentley, Gregory Zimet, J. Patrick McGrail
Summary: The study found that attitudes and subjective norms significantly influenced the intention to get vaccinated against HPV. Knowledge about HPV-related health problems, genital warts, and the vaccine's protective effects were associated with more positive attitudes. Females and non-Caucasians were more likely to have received at least one HPV shot than males and Caucasians.
Article
Immunology
Gabriella Di Giuseppe, Silvia Angelillo, Aida Bianco, Francesca Galle, Francesca Licata, Giorgio Liguori, Francesco Napolitano, Carmelo Giuseppe Angelo Nobile, Maria Pavia, Concetta Paola Pelullo, Italo Francesco Angelillo
Summary: This survey examined the knowledge, attitudes, and behaviors regarding HPV preventive measures among university students in Italy. The results showed that females, those aged 25-30 years, those who have had oral sex, those who have received information from physicians, and those who needed additional information were more knowledgeable. Only 39.1% had received at least one HPV vaccination dose, and factors such as being female, enrolled in health sciences, and having a higher knowledge about HPV were associated with a higher willingness to receive the vaccine.
Article
Biotechnology & Applied Microbiology
Madeleine Waser, Raffael Heiss, Wegene Borena
Summary: An examination of parents' reasons for rejecting children's HPV vaccination and key predictors of vaccination intention reveals an overall acceptance rate of 81.9%. Fear of side effects, lack of information, and the perception that children are too young are the most common reasons for vaccine hesitancy. A high level of knowledge about HPV is associated with vaccine acceptance for female children, while negative attitude towards vaccination and reliance on online sources for information are linked to lower vaccine acceptance. Educational measures are needed to reduce misinformation and improve parents' attitude and knowledge about vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Shu Jia, Bo Pan, Dandan Hong, Qingmei Zhang, Han Jiang, Ying Hong, Jing Hong
Summary: Human papillomavirus (HPV) has a significant impact on global health, and vaccination is an important method for preventing HPV infection. This study investigated the knowledge, attitude, and acceptance of the 9vHPV vaccine among Chinese male college students, and identified factors that predict their willingness to be vaccinated. The findings showed that male college students generally exhibited hesitancy towards the 9vHPV vaccine, but improving their accurate understanding of the vaccine and fostering a positive attitude can enhance their acceptance.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Fahad T. Alsulami, Jesus Sanchez, Silvia E. Rabionet, Ioana Popovici, Mohamed A. Baraka
Summary: The study aimed to measure the HPV vaccination rate and knowledge among foreign-born college students. The results showed that they had moderate knowledge about HPV and the vaccine, with approximately 63% being vaccinated. Perceived susceptibility, perceived barriers, and cues to action were significantly associated with the HPV vaccination behavior, while knowledge and acculturation levels were not significantly associated.
Article
Biotechnology & Applied Microbiology
Md. Emran Hossain, Md. Sayemul Islam, Tanmoy Kumar Ghose, Hasneen Jahan, Sudipto Chakrobortty, Md. Sabbir Hossen, Nishat Sultana Ema
Summary: The study found that most public university students in Bangladesh have a positive attitude towards COVID-19 vaccines, with 78% having adequate knowledge but 37% having negative perceptions. 72.7% of respondents intend to take the vaccine. Female students, those from low-income families, without a COVID-19 infection history, with inadequate knowledge and negative perceptions are more likely to exhibit vaccine hesitancy.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Health Care Sciences & Services
Sally Mohammed Farghaly Abdelaliem, Abeer Mohammed Kuaia, Afnan Ahmed Hadadi, Alhanouf Khalid Alhujayri, Amal Awad Al Anazi, Areen Abdulelah Hajar, Ruba Shayaa AlShareda, Saleha Mohammed Amri
Summary: This article examines the knowledge and attitudes of Saudi Arabian university students towards human papillomavirus (HPV) and its related vaccine. The results show that the majority of participants have a low level of knowledge about HPV, while their attitudes towards the vaccine are moderate. Furthermore, the study finds a significant correlation between nursing students' demographics and their knowledge and attitudes towards HPV.
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Chris J. L. M. Meijer, Willem J. G. Melchers, Ruud L. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert J. van Kemenade, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study validated individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 for the detection of CIN3+ in high-risk HPV-positive women invited for routine screening, showing promising clinical utility.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Caroline L. P. Muntinga, Peggy J. de Vos van Steenwijk, Ruud L. M. Bekkers, Edith M. G. van Esch
Summary: This review outlines the changes in the immune microenvironment in cervical high-grade squamous intraepithelial lesions (cHSILs) and discusses the impact of spontaneous regression, persistence, and immunotherapy on this immune microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Mieke L. G. Ten Eikelder, Floor Hinten, Anke Smits, Maaike A. Van der Aa, Ruud L. M. Bekkers, Joanna IntHout, Hans H. B. Wenzel, Petra L. M. Zusterzeel
Summary: The introduction of the revised FIGO 2018 staging system for cervical cancer has improved the accuracy of predicting survival outcomes for early stage patients. In addition to stage, factors such as LVSI and invasion depth should be considered in treatment decisions. The FIGO 2018 staging system accurately reflects prognosis and allows for better prognostic differentiation.
Article
Oncology
Clare A. Aitken, Federica Inturrisi, Sylvia Kaljouw, Daan Nieboer, Albert G. Siebers, Willem J. G. Melchers, Adriaan J. C. van den Brule, Anco Molijn, John W. J. Hinrichs, Hubert G. M. Niesters, Folkert J. van Kemenade, Johannes Berkhof, Inge M. C. M. de Kok
Summary: In the Netherlands, self-collected samples have lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection compared to clinician-collected samples. The differences between the two sampling methods are likely related to sociodemographic factors as well as differences in screening test accuracy and background risk. Self-sampling can be used as a more convenient screening tool for underscreened women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Lara C. C. Burg, Roy F. P. M. Kruitwagen, Annemarie de Jong, Johan Bulten, Tijmen J. J. Bonestroo, Arjan A. A. Kraayenbrink, Dorry Boll, Sandrina Lambrechts, Huberdina P. M. Smedts, Annechien Bouman, Mirjam J. A. Engelen, Jenneke C. Kasius, Ruud L. M. Bekkers, Petra L. M. Zusterzeel
Summary: This study aims to investigate the incidence of sentinel lymph node (SLN) metastases and the contribution of SLN mapping in the management of presumed low- and intermediate-risk endometrial cancer (EC). A total of 152 patients were enrolled, with overall and bilateral SLN detection rates of 91% and 61%, respectively. The final results showed that SLN metastases were present in 11.2% of patients, and 5.9% of patients had adjuvant radiotherapy based on SLN metastases. The study emphasizes the importance of SLN mapping in presumed early-stage, grade 1 and 2 EC.
Article
Oncology
Anke Smits, Khadra Galaal, Steve Winnan, Alberto Lopes, Ruud L. M. Bekkers
Summary: This study investigated the impact of an individualized exercise program on the quality of life and other health outcomes in endometrial cancer patients. The results demonstrated that the individualized one-to-one exercise intervention is feasible in terms of recruitment, adherence, and safety, and it significantly improved the patients' quality of life, weight, and physical fitness.
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Renee M. F. Ebisch, Willem J. G. Melchers, Ruud L. M. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert van Kemenade, Chris J. L. M. Meijer, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study evaluated the use of DNA methylation analysis as a triage method for high-risk HPV-positive self-collected cervicovaginal samples in cervical cancer screening. The methylation markers ASCL1 and LHX8 showed a sensitivity of 73.3% and specificity of 61.1% for detecting CIN3+. Compared to clinician-collected samples, self-collected samples had a relative sensitivity of 0.95 and relative specificity of 0.82. Therefore, the ASCL1/LHX8 methylation marker panel is a feasible triage method for HPV-positive women participating in routine self-sampling.
BRITISH JOURNAL OF CANCER
(2023)
Article
Microbiology
Jodie A. Schildkraut, Jordy P. M. Coolen, Heleen Severin, Ellen Koenraad, Nicole Aalders, Willem J. G. Melchers, Wouter Hoefsloot, Heiman F. L. Wertheim, Jakko van Ingen
Summary: We introduce a new sequencing technique that can identify nontuberculous mycobacteria (NTM) to (sub)species level based on whole-genome extracted from enriched shotgun metagenomic data. This technique can be used to study the association between genotypes and clinical manifestations and pave the way for personalized healthcare.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Microbiology
Tim J. H. Baltussen, Norman van Rhijn, Jordy P. M. Coolen, Jan Dijksterhuis, Paul E. Verweij, Michael J. Bromley, Willem J. G. Melchers
Summary: Germination of inhaled Aspergillus fumigatus conidia is a necessary step for infection. The transcription factor SltA plays a crucial role in regulating germination and hyphal development.
Article
Microbiology
Simone J. C. F. M. Moorlag, Jordy P. M. Coolen, Bart van den Bosch, Elisabeth Hui-Mei Jin, Jochem B. B. Buil, Heiman F. L. Wertheim, Willem J. G. Melchers
Summary: The study evaluates the clinical utility of a novel method called 16S RC-PCR for the identification of bacterial species. It shows that this method is more sensitive and accurate compared to the traditional 16S Sanger sequencing method, leading to improved clinical outcomes and patient care.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Isidor Happacher, Mario Aguiar, Mostafa Alilou, Beate Abt, Tim J. H. Baltussen, Clemens Decristoforo, Willem J. G. Melchers, Hubertus Haas
Summary: Aspergillus fumigatus, a common airborne fungal pathogen, utilizes two high-affinity iron uptake mechanisms, reductive iron assimilation (RIA) and siderophore-mediated iron acquisition (SIA), to maintain iron homeostasis and enhance virulence. This study focused on understanding iron acquisition during germination and revealed that ferricrocin, a siderophore, plays a crucial role in this process. Ferricrocin was found to be secreted and taken up during early germination, regardless of iron availability, indicating developmental regulation of this iron acquisition system. These findings provide insights into the mechanisms of iron acquisition and suggest potential targets for the diagnosis and treatment of fungal infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Sharell Bas, Jasmijn Sijben, Erik W. M. A. Bischoff, Ruud L. M. G. Bekkers, Inge M. C. M. de Kok, Willem J. G. Melchers, Albert Siebers, Danielle van der Waal, Mireille J. M. Broeders
Summary: This qualitative study aimed to gain insights into the acceptability of risk-based triage in cervical cancer screening among women aged 30-60 years. The study identified several factors that influence the acceptability of risk-stratified triage, such as the adequacy of the screening program, personal information, emotional impact, communication, and autonomy.
Article
Microbiology
Margriet W. J. Hokken, Jordy P. M. Coolen, Hilbert Steenbreker, Jan Zoll, Tim J. H. Baltussen, Paul E. Verweij, Willem J. G. Melchers
Summary: This study compared the adaptational response to azole drugs from A. fumigatus isolates with different azole susceptibility and genetic backgrounds. Through RNA sequencing, it was found that there were many similarities in up-regulation of ergosterol biosynthesis across isolates, except for the pan-azole-resistant isolate which showed very little differential regulation compared to other isolates. Additionally, differential regulation of membrane efflux transporters, secondary metabolites, iron metabolism, and various stress response and cell signaling mechanisms were observed.
Review
Microbiology
Sofie C. M. Tops, Claire E. P. Schapendonk, Jordy P. M. Coolen, Fred C. Tenover, Isabella A. Tickler, Willem J. G. Melchers, Heiman F. L. Wertheim
Summary: The increasing prevalence of ESBL-producing Enterobacterales has implications for the empirical treatment of common infections. Rapid identification of ESBL-containing pathogens is desirable to provide effective treatment without resorting to last resort antibiotics.
MICROBIOLOGY SPECTRUM
(2023)
Review
Oncology
Lara C. Burg, Shenna Verheijen, Ruud L. M. Bekkers, Joanna IntHout, Robert W. Holloway, Salih Taskin, Sarah E. Ferguson, Yu Xue, Antonino Ditto, Glauco Baiocchi, Andrea Papadia, Giorgio Bogani, Alessandro Buda, Roy F. P. M. Kruitwagen, Petra L. M. Zusterzeel
Summary: The use of indocyanine green in SLN mapping shows a high detection rate and negative predictive value in low- and intermediate-risk endometrial cancers, providing important clinical guidance for choosing appropriate treatment options.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
