Article
Psychiatry
Nirunya Narupan, Acharaporn Seeherunwong, Walailak Pumpuang
Summary: This study aimed to estimate the prevalence and examine biopsychosocial factors of depressive symptoms among patients with systemic lupus erythematosus (SLE). The findings showed a high proportion of depressive symptoms in patients with SLE, which were associated with severe pain, fatigue, high dose of prednisolone, low body image satisfaction, and low social support.
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Seerat Chawla, Jiandong Su, Zahi Touma, Patricia Katz
Summary: The aim of this study was to determine the trajectories of depressive symptoms in SLE patients and identify baseline characteristics associated with the trajectory of depression. The study analyzed data from the Lupus Outcomes Study, mapping CES-D scores for 763 individuals with SLE over 6 years into four distinct classes. Results showed that older age and higher education level were associated with lower odds of membership in worse classes of depressive symptoms, while lower income, worse physical functioning, and worse bodily pain scores were positively associated with membership in worse classes of depressive symptoms. Understanding the trajectories of depressive symptoms and associated risk factors can help manage these symptoms in individuals living with SLE.
Review
Immunology
S. Giambalvo, C. Garaffoni, E. Silvagni, F. Furini, R. Rizzo, M. Govoni, A. Bortoluzzi
Summary: This systematic literature review aimed to explore the factors associated with fertility outcomes in women of childbearing age with systemic lupus erythematosus (SLE). The study found that exposure to cyclophosphamide and its cumulative dose can impair gonadal function in SLE women, leading to amenorrhea and premature ovarian failure (POF). Certain treatments were associated with a lower risk of POF. Hormonal and serological factors did not appear to impact fertility outcomes, but could be used as surrogate markers of fertility.
AUTOIMMUNITY REVIEWS
(2022)
Article
Microbiology
Lifan Zhang, Yanan Ma, Nan Jiang, Xiaoqing Zou, Yueqiu Zhang, Fengchun Zhang, Xiaofeng Zeng, Yan Zhao, Shengyun Liu, Xiaoxia Zuo, Huaxiang Wu, Lijun Wu, Hongbin Li, Zhiyi Zhang, Sheng Chen, Ping Zhu, Miaojia Zhang, Wencheng Qi, Yi Liu, Huaxiang Liu, Xiaochun Shi, Xiaoqing Liu
Summary: The study aimed to determine the prevalence of latent tuberculosis infection (LTBI) among systemic lupus erythematosus (SLE) patients using the T-SPOT.TB assay and identify factors influencing the assay results. A total of 2,229 SLE patients were screened, with a positivity rate of 15%. Factors such as age over 40, evidence of previous tuberculosis, and disease severity were associated with positive T-SPOT.TB results, while high-dose glucocorticoid treatment and some types of immunosuppressants were associated with negative results. The study highlights the importance of active LTBI screening and preventive intervention in SLE patients in China.
MICROBIOLOGY SPECTRUM
(2023)
Article
Rheumatology
G. Olivieri, F. Ceccarelli, C. Perricone, C. Ciccacci, C. Pirone, F. Natalucci, F. R. Spinelli, C. Alessandri, P. Borgiani, F. Conti
Summary: Fever has been included as a new classification criterion for systemic lupus erythematosus (SLE). This study explored the association of fever with other clinical manifestations and found significant correlations with serositis and hematological manifestations. A specific SNP (rs13361189) in the IRGM gene was also found to be associated with fever.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Valeria Orefice, Fulvia Ceccarelli, Carmelo Pirone, Paola Galoppi, Francesca Romana Spinelli, Cristiano Alessandri, Roberto Brunelli, Giuseppina Perrone, Fabrizio Conti
Summary: The study found that almost all SLE pregnant women planned to breastfeed (96.5%), but only 71.9% actually did, with a median duration of 3 months. Non-breastfeeding women had a higher likelihood of c-section, IUGR, and disease relapse after pregnancy. Early discontinuation of breastfeeding was associated with smoking, BMI, joint involvement, while longer duration was linked to disease duration and HCQ treatment during postpartum.
Article
Immunology
Shirley C. W. Chan, Yong-Fei Wang, Desmond Y. H. Yap, Tak Mao Chan, Yu Lung Lau, Pamela P. W. Lee, Wai Ming Lai, Shirley K. Y. Ying, Niko K. C. Tse, Alexander M. H. Leung, Chi Chiu Mok, Ka Lai Lee, Teresa W. L. Li, Helen H. L. Tsang, Winnie W. Y. Yeung, Carmen T. K. Ho, Raymond W. S. Wong, Wanling Yang, Chak Sing Lau, Philip H. Li
Summary: A risk stratification strategy (RIFLE-LN) was developed to predict the risk of lupus nephritis (LN) among Chinese SLE patients, using male sex, anti-dsDNA positivity, age of SLE onset, and SLE duration. The algorithm was validated in an independent cohort.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Chia-Wen Hsu, Bao-Bao Hsu, Malcolm Koo, Ming-Chi Lu
Summary: This study investigated the association of demographic factors, clinical manifestations, and disease activity of SLE with intimate relationships in female patients. The results showed that younger age, higher education level, employment, better self-reported health status, and lower SLE-DAS score were associated with better intimate relationships. In addition, intimate relationships were significantly associated with physical health, fatigue, and burden to others.
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Liping Xu, Xinwei Song, Qiaoding Dai, Tianrong Guan, Yan Zhang, Na Lin, Ji-an Wang
Summary: This case report highlights the efficacy of Belimumab in treating refractory Lupus Cystitis, with significant improvements in symptoms, urinary markers, and protein levels observed in the patient. No relapse of lupus cystitis or SLE activity occurred during the 10-month follow-up period, demonstrating positive outcomes with Belimumab treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pediatrics
Ana Luisa Rodriguez-Lozano, Francisco Eduardo Rivas-Larrauri, Silvestre de la Puente, Daniel Alfredo Alcivar-Arteaga, Alejandro Gabriel Gonzalez-Garay
Summary: This study found that neurologic disease, vasculitis, and hemolytic anemia present at diagnosis in childhood-onset systemic lupus erythematosus patients are prognostic factors associated with the development of damage. Therefore, closer follow-up is recommended for patients with these factors to reduce the likelihood of damage development.
FRONTIERS IN PEDIATRICS
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Rheumatology
Orawan Sae-lim, Intouch Laobandit, Punyawee Kitchanwit, Manthana Laichapis, Boonjing Siripaitoon
Summary: The study found that up to 25% of SLE patients poorly adhered to their prescriptions. Factors such as age, reimbursement scheme, pill number, and attitude towards SLE were associated with nonadherence in these patients.
Article
Multidisciplinary Sciences
Yuan-yuan Qi, Yan Cui, Hui Lang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Xin-ran Liu, Ya-fei Zhao, Xiang-hui Ning, Zhan-zheng Zhao
Summary: Genetic studies have linked the rs10947540 single-nucleotide polymorphism (SNP) in the ZNF76 gene with susceptibility to systemic lupus erythematosus (SLE) in Chinese populations. Carrier individuals of the C allele of rs10947540 were found to have a higher risk of developing SLE with elevated levels of serum creatinine. Bioinformatic analysis revealed a correlation between this SNP and decreased expression of ZNF76, suggesting a potential role in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)