4.6 Article

The effect of major depression on postexercise cardiovascular recovery

Journal

PSYCHOPHYSIOLOGY
Volume 48, Issue 11, Pages 1604-1609

Publisher

WILEY
DOI: 10.1111/j.1469-8986.2011.01232.x

Keywords

Depression; Heart rate (HR); Blood pressure (BP); Cardiovascular recovery; Exercise; Autonomic nervous system (ANS)

Funding

  1. Heart and Stroke Foundation of Quebec
  2. Canadian Institutes of Health Research (CIHR) [MOP79445, MOP89965]
  3. Canadian Hypertension Society
  4. le Fonds de la recherche en sante du Quebec (FRSQ)
  5. Vanier Ph.D. fellowship
  6. CIHR

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Major depressive disorder (MDD) is associated with increased cardiovascular (CV) mortality. Dysfunctional autonomic control of the CV system may represent a mechanism explaining this relationship. Poor CV recovery after exercise, indicative of dysfunctional autonomic control of the CV system, predicts CV events and death. This is the first study to examine the association between MDD and postexercise CV recovery. Some 886 patients underwent exercise stress tests. Heart rate (HR), systolic blood pressure, and diastolic blood pressure were measured at rest, peak exercise, 1 min, and 5 min after exercise. Patients with MDD had slower HR recovery (p = .026) 1 min after exercise than non-MDD patients. No other effects of MDD were found. MDD is accompanied by a dysregulation in autonomic control of exercise-related CV recovery, suggesting that depressed individuals have a slow parasympathetic recovery from exercise.

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