NOP agonists prevent the antidepressant-like effects of nortriptyline and fluoxetine but not R-ketamine

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

(2018) Kristian G. du Jardin et al.   Frontiers in Pharmacology

5-Hydroxytryptamine-Independent Antidepressant Actions of (R)-Ketamine in a Chronic Social Defeat Stress Model

(2017) Kai Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant Potential of ( R )-Ketamine in Rodent Models: Comparison with ( S )-Ketamine

(2017) Kenichi Fukumoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress

(2017) Giovanni Vitale et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

(2016) L. Asth et al.   NEUROPHARMACOLOGY

Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness

(2016) Victor A. D. Holanda et al.   PSYCHOPHARMACOLOGY

The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN

(2015) Kenichi Fukumoto et al.   NEUROPSYCHOPHARMACOLOGY

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

(2015) Anke Post et al.   NEUROPSYCHOPHARMACOLOGY

Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice

(2015) Iris U. Medeiros et al.   PEPTIDES

The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice

(2014) Juliana Cavalcante de Moura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3-c]pyran) Scaffold

(2014) Miguel A. Toledo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin

(2013) Erwan Le Maître et al.   BRAIN RESEARCH

Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs

(2013) Elaine Cristina Gavioli et al.   PHARMACOLOGY & THERAPEUTICS

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

(2013) Jeffrey M. Witkin et al.   PHARMACOLOGY & THERAPEUTICS

Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism

(2013) Valentina Gigliucci et al.   PSYCHOPHARMACOLOGY

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair

(2012) Celia Goeldner et al.   PSYCHOPHARMACOLOGY

Effect of stress on hippocampal nociceptin expression in the rat

(2012) Paola Nativio et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Helplessness: A systematic translational review of theory and evidence for its relevance to understanding and treating depression

(2011) Christopher R. Pryce et al.   PHARMACOLOGY & THERAPEUTICS

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nociceptin/orphanin FQ receptor knockout rats: In vitro and in vivo studies

(2010) Anna Rizzi et al.   NEUROPHARMACOLOGY

Nociceptin/orphanin FQ and NOP receptor gene regulation after acute or repeated social defeat stress

(2009) Megan K. Green et al.   NEUROPEPTIDES

Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: Role of corticotropin releasing factor

(2009) Cristiano Nazzaro et al.   NEUROPHARMACOLOGY

Chronic treatment with the selective NOP receptor antagonist [Nphe1,Arg14,Lys15]N/OFQ-NH2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats

(2009) Giovanni Vitale et al.   PSYCHOPHARMACOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY