Article
Neurosciences
Ivan Banovac, Dora Sedmak, Monique Esclapez, Zdravko Petanjek
Summary: In this study, the molecular expression, morphological features, and laminar distribution of somatostatin cells in the human prefrontal cortex were comprehensively analyzed. The results showed that somatostatin neurons comprise around 7% of neocortical neurons, with different molecular and morphological characteristics in different cortical layers.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Psychiatry
Mingxing Li, Xuejiao Sun, Zongqin Wang, Yi Li
Summary: This study found that chronic stress-induced depression-like behaviors are associated with neuroinflammation and GABAergic dysfunction. The levels of caspase-1-IL-1β in the serum and hippocampus were significantly increased, and there was a significant negative correlation between caspase-1 levels and depression-like behaviors. Chronic stress decreased GAD67 mRNA levels and GABAergic neurotransmission, leading to reduced GABA concentration, decreased amplitude and frequency of mIPSCs, and reduced surface expression of GABA(A)Rs γ2 subunit in the hippocampus. Genetic deficiency of caspase-1 blocked stress-induced depression-like behaviors and alleviated impairments in GABAergic neurotransmission. Reexpression of caspase-1 in the hippocampus increased susceptibility to stress-induced anxiety- and depression-like behaviors. This study suggests that targeting caspase-1 may provide potential therapeutic benefits for stress-related GABAergic dysfunction in the pathogenesis of MDD.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Neurosciences
Miriam C. Klein-Flugge, Alessandro Bongioanni, Matthew F. S. Rushworth
Summary: The medial frontal cortex and adjacent orbitofrontal cortex have different functional roles in decision-making, behavioral flexibility, and social behavior. Recent studies show that their representation of value and choices is more complex than previously thought.
Article
Clinical Neurology
Stefano Delli Pizzi, Raffaella Franciotti, Piero Chiacchiaretta, Antonio Ferretti, Richard A. Edden, Carlo Sestieri, Mirella Russo, Stefano L. Sensi, Marco Onofrj
Summary: This study aims to investigate the neural mechanisms of somatic symptom disorder (SSD) in Parkinson's disease (PD) patients. The results showed that patients with SSD exhibited higher gamma-aminobutyric acid (GABA) levels and connectivity in the medial prefrontal cortex (mPFC), indicating both shared and individual effects of PD and SSD on mPFC neurotransmission and connectivity patterns.
MOVEMENT DISORDERS
(2022)
Article
Anatomy & Morphology
Elizabeth Woo, Dibyadeep Datta, Amy F. T. Arnsten
Summary: mGlu3 receptors are mainly expressed in neurons and astrocytes in rat PL mPFC, and are also found in microglia to a lesser extent. They are predominantly located on axons and widely distributed in the glial membrane, but are also present on dendritic spines, particularly in layer III.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Diana Lucaci, Xiao Yu, Paul Chadderton, William Wisden, Stephen G. Brickley
Summary: We investigated the effects of histamine and GABA release from TMN axons projecting to the PFC on circuit processing. Histamine stimulated fast-spiking interneurons, while released GABA enhanced tonic inhibition on PyrNs. Histamine-induced gain changes were blocked by histamine receptor antagonists, while GABA-induced gain changes were blocked by GABAA receptor antagonists. The GABA modulation of PyrN excitability by TMNHDC axons increased significantly in older mice, potentially enhancing information processing and maintaining cognition in aging individuals.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Molly Simmonite, Clara J. Steeby, Stephan F. Taylor
Summary: GABA abnormalities may contribute to the pathophysiology of psychosis spectrum and mood disorders. Lower GABA levels were found in the mid- and posterior medial frontal cortex of schizophrenia patients, while increased GABA levels were observed in the rostral medial frontal cortex of bipolar disorder patients.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Luca F. Kaiser, Theo O. J. Gruendler, Oliver Speck, Lennart Luettgau, Gerhard Jocham
Summary: The balance between excitation and inhibition in the dorsal anterior cingulate cortex plays a role in patch-leaving decisions, while the same balance in the ventromedial prefrontal cortex is related to value-guided decision-making. This differential relationship highlights the importance of weighing immediate rewards against long-term gains in different cortical areas.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Juan Carlos Cerpa, Alessandro Piccin, Margot Dehove, Marina Lavigne, Eric J. Kremer, Mathieu Wolff, Shauna L. Parkes, Etienne Coutureau
Summary: Organisms need to track the relationship between actions and consequences in order to make decisions, which relies on circuits in the brain. There is functional heterogeneity within certain areas of the brain in rodents. Neuromodulatory agents play a crucial role in prefrontal functions and behavioral flexibility.
Article
Anatomy & Morphology
Szilard Szocs, Nora Henn-Mike, Agnes Agocs-Laboda, Edina Szabo-Meleg, Csaba Varga
Summary: A recent study found that neurogliaform cells in layer I of the medial entorhinal cortex play a critical role in local feedback inhibition. These cells receive excitatory inputs from layer II pyramidal cells, potentially inhibiting the apical dendrites of principal cells in the cortex. The distribution of neurogliaform cells in layer I is not correlated with the compartmentalization seen in layer II.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Neurosciences
Kyla Gaeul Lee, Nagalingam Rajakumar
Summary: The impact of diseases on early brain development may lead to behavioral abnormalities in schizophrenia during adulthood. Delayed maturation of GABA function and lesions in the subplate are related to the clinical manifestations of schizophrenia.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Atsumi Nitta, Naotaka Izuo, Kohei Hamatani, Ryo Inagaki, Yuka Kusui, Kequan Fu, Takashi Asano, Youta Torii, Chikako Habuchi, Hirotaka Sekiguchi, Shuji Iritani, Shin-ichi Muramatsu, Norio Ozaki, Yoshiaki Miyamoto
Summary: Suppressing Piccolo in the medial prefrontal cortex of mice leads to a reduction in synaptic proteins, electrophysiological impairments, and abnormal behaviors resembling those seen in schizophrenia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Yonglin Lin, Ruolei Gu, Jiali Zhou, Yiman Li, Pengfei Xu, Yue-jia Luo
Summary: The study found that social information can impact decision-making, with Social Misalignment Sensitivity and egocentric tendency playing important roles in this process. Different brain regions were activated in socially aligned and misaligned situations, indicating variations in the monitoring system's scope. The dorsolateral prefrontal cortex may selectively interact with SMS in individuals with a low switching threshold, suggesting sensitivity to inter-individual variation.
Article
Clinical Neurology
Kim H. Tran, Jessica Luki, Sarah Hanstock, Christopher C. Hanstock, Peter Seres, Katherine Aitchison, Tami Shandro, Jean-Michel Le Melledo
Summary: This study suggests that perimenopause is associated with decreased GABA levels in the medial prefrontal cortex, potentially contributing to the risk of developing a major depressive episode during perimenopause.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Tracie A. Paine, Elizabeth K. Cooke, Daniel C. Lowes
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2015)
Review
Neurosciences
Neil L. Harrison, Mary Jane Skelly, Emma K. Grosserode, Daniel C. Lowes, Tamara Zeric, Sara Phister, Michael C. Sailing
Article
Multidisciplinary Sciences
Lindsay M. McCracken, Daniel C. Lowes, Michael C. Salling, Cyndel Carreau-Vollmer, Naomi N. Odean, Yuri A. Blednov, Heinrich Betz, R. Adron Harris, Neil L. Harrison
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Cell Biology
Arjun V. Masurkar, Kalyan V. Srinivas, David H. Brann, Richard Warren, Daniel C. Lowes, Steven A. Siegelbaum
Article
Neurosciences
Arjun Masurkar, Chengju Tian, Richard Warren, Isabel Reyes, Daniel C. Lowes, David H. Brann, Steven A. Siegelbaum
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Alan J. Park, Alexander Z. Harris, Kelly M. Martyniuk, Chia-Yuan Chang, Atheir I. Abbas, Daniel C. Lowes, Christoph Kellendonk, Joseph A. Gogos, Joshua A. Gordon
Summary: Novelty helps reset neural circuits in the brain to promote adaptive learning. Exposure to novelty environment reorganizes neural circuits in mice, enhancing learning-related plasticity, and this effect can be mediated by dopamine D1 receptors.
Article
Multidisciplinary Sciences
Daniel C. Lowes, Linda A. Chamberlin, Lisa N. Kretsge, Emma S. Holt, Atheir Abbas, Alan J. Park, Lyubov Yusufova, Zachary H. Bretton, Ayesha Firdous, Armen G. Enikolopov, Joshua A. Gordon, Alexander Z. Harris
Summary: In this study, researchers found that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behavior in mice.
NATURE COMMUNICATIONS
(2021)