Journal
PSYCHOPHARMACOLOGY
Volume 227, Issue 3, Pages 493-499Publisher
SPRINGER
DOI: 10.1007/s00213-013-2967-2
Keywords
Synthetic cathinones; Cocaine; Dopamine transporter; hDAT; Mephedrone; Methamphetamine; Methcathinone; Methylenedioxypyrovalerone; Drug abuse
Categories
Funding
- PHS [DA033930, DA02694702]
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Psychoactive bath salts represent a relatively new drug of abuse combination that was placed in Schedule I in October 2011. Two common ingredients of bath salts include the cathinone analogs: mephedrone and methylenedioxypyrovalerone (MDPV). The mechanism of action of these synthetic cathinone analogs has not been well investigated. Because cathinone and methcathinone are known to act as releasing agents at the human dopamine transporter (hDAT), mephedrone and MDPV were investigated at hDAT expressed in Xenopus oocytes. Whereas mephedrone was found to have the signature of a dopamine-releasing agent similar to methamphetamine or methcathinone, MDPV behaved as a cocaine-like reuptake inhibitor of dopamine. Mephedrone and MDPV produce opposite electrophysiological signatures through hDAT expressed in oocytes. Implications are that the combination (as found in bath salts) might produce effects similar to a combination of methamphetamine and cocaine.
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