The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque
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Title
The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque
Authors
Keywords
Alzheimer’s disease, Acetylcholine, Muscarinic, Cognition, Object recognition, Working memory
Journal
PSYCHOPHARMACOLOGY
Volume 225, Issue 1, Pages 21-30
Publisher
Springer Nature
Online
2012-07-23
DOI
10.1007/s00213-012-2788-8
References
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Note: Only part of the references are listed.- Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment
- (2012) Wenjun Li et al. NEUROIMAGE
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- (2011) Scott D. Kuduk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2011) Julien Delrieu et al. CNS DRUGS
- Discovery of a Selective Allosteric M1Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold
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- (2011) M. L. Watt et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Control of cerebral cortical blood flow by stimulation of basal forebrain cholinergic areas in mice
- (2011) Harumi Hotta et al. Journal of Physiological Sciences
- N-Heterocyclic derived M1 positive allosteric modulators
- (2010) Scott D. Kuduk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2010) Paul R. Reid et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Neuronal localization of m1 muscarinic receptor immunoreactivity in the rat basolateral amygdala
- (2010) Alexander Joseph McDonald et al. Brain Structure & Function
- The Muscarinic Long-Term Enhancement of NMDA and AMPA Receptor-Mediated Transmission at Schaffer Collateral Synapses Develop through Different Intracellular Mechanisms
- (2010) D. F. de Sevilla et al. JOURNAL OF NEUROSCIENCE
- Modulation of somatosensory-evoked cortical blood flow changes by GABAergic inhibition of the nucleus basalis of Meynert in urethane-anaesthetized rats
- (2010) Mathieu Piché et al. JOURNAL OF PHYSIOLOGY-LONDON
- M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK Channels
- (2010) Andrew J. Giessel et al. NEURON
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- (2010) Katherine A. Buchanan et al. NEURON
- A novel derivative of xanomeline improves fear cognition in aged mice
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- (2009) Evan P Lebois et al. ACS Chemical Neuroscience
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- (2009) Scott D. Kuduk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Safety and Tolerability of Donepezil, Rivastigmine and Galantamine for Patients with Alzheimer’s Disease: Systematic Review of the ‘Real-World’ Evidence
- (2009) I.A. Lockhart et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists
- (2009) Julia N. Heinrich et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning
- (2009) J. K. Shirey et al. JOURNAL OF NEUROSCIENCE
- AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model
- (2009) Stefania Risso Bradley et al. NEUROPHARMACOLOGY
- Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
- (2009) L. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats
- (2008) C. K. Jones et al. JOURNAL OF NEUROSCIENCE
- A novel derivative of xanomeline improved memory function in aged mice
- (2008) Yi-Hui Cui et al. Neuroscience Bulletin
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