Cariprazine, a dopamine D3-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse

Impact of Neurocognition on Social and Role Functioning in Individuals at Clinical High Risk for Psychosis

(2011) Ricardo E. Carrión et al.   AMERICAN JOURNAL OF PSYCHIATRY

Strain-specific cognitive deficits in adult mice exposed to early life stress.

(2011) Mukti Mehta et al.   BEHAVIORAL NEUROSCIENCE

Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

(2011) István Gyertyán et al.   NEUROCHEMISTRY INTERNATIONAL

Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

(2011) David JG Watson et al.   NEUROPSYCHOPHARMACOLOGY

Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography

(2011) Nicholas Seneca et al.   PSYCHOPHARMACOLOGY

Third Generation Antipsychotic Drugs: Partial Agonism or Receptor Functional Selectivity?

(2010) Richard Mailman et al.   CURRENT PHARMACEUTICAL DESIGN

Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

(2010) B. Kiss et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A role for dopamine D2 receptors in reversal learning

(2009) D.A. DeSteno et al.   NEUROSCIENCE

DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents

(2008) Igor Bombin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: Mediating influence of the alpha-2A adrenoceptor subtype

(2008) J. David Jentsch et al.   BRAIN RESEARCH

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: Role of serotonin 5-HT1A receptors

(2008) Hiroko Hagiwara et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D1 receptor agonists, but not of D2 antagonists

(2008) Florence Loiseau et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Effects of repeated treatment of phencyclidine on cognition and gene expression in C57BL/6 mice

(2008) Simret Beraki et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors

(2008) Taku Nagai et al.   PSYCHOPHARMACOLOGY