Article
Biology
Marcus M. Weera, Abigail E. Agoglia, Eliza Douglass, Zhiying Jiang, Shivakumar Rajamanickam, Rosetta S. Shackett, Melissa A. Herman, Nicholas J. Justice, Nicholas W. Gilpin
Summary: We have successfully generated and validated a transgenic CRF1-Cre-(td)Tomato rat model, which can be used to study the role of CRF1 receptor-expressing neurons in hormone-mediated behaviors. We found that the expression pattern of this rat model is similar to the known expression pattern of CRF1 cells, and it can be investigated using modern genetic techniques.
Article
Immunology
Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huang
Summary: Depressed mice have lower numbers of microglia in the dentate gyrus. Reversing this decline with a single low dose of lipopolysaccharide has antidepressant effects. The antidepressant effect is related to the synthesis and signaling pathway of brain-derived neurotrophic factor.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Muhammad Asim, Huajie Wang, Xi Chen, Jufang He
Summary: This study investigates the role of basolateral amygdala (BLA) neurons in mediating the behavior associated with depression. The results suggest that increased activity of excitatory BLA neurons can lead to depressive-like behavior, while inhibition of these neurons can alleviate such behavior. Additionally, inhibiting GABAergic neurons in the BLA can increase the firing frequency of excitatory neurons and mediate depressive-like phenotypes. Furthermore, activating inhibitory neurons can inhibit the activity of excitatory neurons and alleviate depressive-like behavior.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Hirofumi Tesen, Keita Watanabe, Naomichi Okamoto, Atsuko Ikenouchi, Ryohei Igata, Yuki Konishi, Shingo Kakeda, Reiji Yoshimura
Summary: This study found that the volume of the right amygdala is associated with the severity of depression and certain symptoms in patients with major depression, while the left amygdala showed no association. However, there have been few reports on the relationship between depression and amygdala subregional volume, and further research is needed for further validation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Yuki Higuchi, Tomoaki Tada, Taiga Nakachi, Hiroyuki Arakawa
Summary: This study investigated the alterations in 5-HT signaling and functionality in BTBR mice and their contribution to abnormal behaviors. Results showed a reduced number of 5-HT neurons in the median raphe of BTBR mice and decreased responsiveness to the 5-HT1A receptor agonist buspirone. Additionally, blunted c-Fos responses in the BLA and Hipp regions of BTBR mice were associated with a lack of anxiety-like behavior.
Article
Neurosciences
Jie Fan, Feng Gao, Xiang Wang, Qian Liu, Jie Xia, Yan Han, Jinyao Yi, Changlian Tan, Xiongzhao Zhu
Summary: This study examined the impact of childhood trauma (CT) on amygdala and hippocampus functional connectivity (FC) and its association with major depressive disorder (MDD). The results showed that individuals with moderate-to-severe CT had decreased right amygdala-right precuneus connectivity irrespective of MDD diagnosis. This connectivity was significantly correlated with physical and social trait anhedonia in MDD. The findings highlight the role of CT in the FC between right amygdala and right precuneus, suggesting a potential mechanism linking CT and depression through trait anhedonia.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Qi Zhang, Shun-Heng Gao, Zhong-Shan Shen, Yun Wang, Su-Wan Hu, Guang-Bing Duan, Ye Liu, Dan-Ya Zhong, Jing Liu, Meng-Han Sun, Xin Zhang, Tian-Yu Cao, Jun-Li Cao, Qiong-Yao Tang, Zhe Zhang
Summary: Anxiety disorders are mental disorders characterized by anxiety and fear, and their molecular basis is still unclear. The study reveals the role of Slack channels in controlling anxious behaviors by decreasing the excitability of BLA-vHPC glutamatergic projections. This provides a potential target for anxiolytic therapies.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Hongqi Xiao, Minlan Yuan, Hailong Li, Shiyi Li, Yang Du, Mei Wang, Hongru Zhu, Wei Zhang, Changjian Qiu, Xiaoqi Huang
Summary: The study demonstrates that the functional connectivity of the left hippocampus can predict early efficacy of antidepressants. The ROC curve analysis shows that the FC measures between the left hippocampus and the left inferior frontal gyrus and precuneus are crucial for differentiating early improved and non-improved depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Baovi N. Vo, Ezequiel Marron Fernandez de Velasco, Timothy R. Rose, Hannah Oberle, Haichang Luo, Corey R. Hopkins, Kevin Wickman
Summary: Systemic administration of ML297 suppressed avoidance behavior in male C57BL/6J mice by activating GIRK channels, with the neuronal activation patterns, administration site, and neuron types playing crucial roles in influencing the behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Vivien Miczan, Krisztina Kelemen, Judit R. Glavinics, Zsofia Laszlo, Benjamin Barti, Kata Kenesei, Mate Kisfali, Istvan Katona
Summary: The molecular repertoire of calcium-binding proteins in Ca2+ signaling pathways plays a crucial role in meeting the specific kinetic requirements of Ca2+-dependent processes in different types of neurons. By investigating CB1/CCK-positive interneurons, it was revealed that NECAB1 and NECAB2 are predominant calcium-binding proteins in this cell type, showing functional differences at the subcellular nanoscale level.
Article
Immunology
Anqi Kong, Tianyao Liu, Shilong Deng, Shiyao Xu, Yi Luo, Jianghui Li, Zhulin Du, Liuyongwei Wang, Xingshun Xu, Xiaotang Fan
Summary: Depression is a common mental disease and is highly prevalent in populations. Dysregulated neuroinflammation and concomitant-activated microglia are involved in the pathogenesis of depression. Experimental evidence has indicated that fullerenol exerts anti-neuroinflammation and protective effects against neurological diseases. Here, we evaluated fullerenol's effects against lipopolysaccharide (LPS)-induced mouse depressive-like behaviors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuko Hakamata, Shinya Mizukami, Shuhei Izawa, Hisayoshi Okamura, Kengo Mihara, Hilary Marusak, Yoshiya Moriguchi, Hiroaki Hori, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya
Summary: Research suggests that anxiety and depression are related to memory biases, with anxiety facilitating an initial focus on negative information and implicit memory bias being influenced by anxiety. The neural connectivity and hormone interaction may serve as important targets in the treatment of comorbid anxiety and depressive disorders.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mats Holmberg, Helge Malmgren, Rolf A. Heckemann, Birgitta Johansson, Niklas Klasson, Erik Olsson, Simon Skau, Goran Starck, Helena Filipsson Nystrom
Summary: The study found that Graves disease (GD) affects regional medial temporal lobe (MTL) volumes, with patients having smaller MTL regions compared to controls before treatment, and increased volumes in MTL regions after treatment. There were significant correlations between thyrotropin receptor antibodies (TRAb) levels and MTL volumes, as well as between free 3,5,3'-triiodothyronine levels and TRAb levels with MTL volumes. However, there were no significant correlations between symptoms or test scores and MTL volumes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Aurelio Franco-Garcia, Victoria Gomez-Murcia, Francisco Jose Fernandez-Gomez, Raul Gonzalez-Andreu, Juana M. Hidalgo, M. Victoria Milanes, Cristina Nu Nunez
Summary: Chromatin modification plays a crucial role in various brain processes, including drug addiction. The induction and persistence of drug-induced behavior and molecular changes can be explained by drug-induced epigenetic mechanisms. This study investigated the epigenetic regulation during aversive memory retrieval and extinction in opiate withdrawal, revealing the involvement of histone acetylation and p-Brd4 in these processes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
El Cherif Ibrahim, Victor Gorgievski, Pilar Ortiz-Teba, Raoul Belzeaux, Gustavo Turecki, Etienne Sibille, Guillaume Charbonnier, Eleni T. Tzavara
Summary: Antidepressants are currently the best treatment for moderate to severe major depressive episodes, but the trial-and-error prescription strategy and side effects are concerning. There is a lack of biomarkers to aid in treatment decisions, highlighting the need for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)