Translational PK–PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576

RETRACTED: Relationship between dopamine D2 receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine

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Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats

(2009) Trine Damgaard et al.   BEHAVIOURAL BRAIN RESEARCH

The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats

(2009) Eugene Hamlyn et al.   BEHAVIOURAL PHARMACOLOGY

Receptor Occupancy and Brain Free Fraction

(2009) J. Watson et al.   DRUG METABOLISM AND DISPOSITION

Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus

(2009) Xiaowei W. Su et al.   PSYCHOPHARMACOLOGY

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting

(2009) Brian Villumsen Broberg et al.   PSYCHOPHARMACOLOGY

Dopamine Modulates Temporal Dynamics of Feedforward Inhibition in Rat Prefrontal Cortex In Vivo

(2008) P. L. Tierney et al.   CEREBRAL CORTEX

Development of Translational Pharmacokinetic–Pharmacodynamic Models

(2008) DE Mager et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ionotropic Glutamate Receptors & CNS Disorders

(2008) Derek Bowie   CNS & Neurological Disorders-Drug Targets

Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat

(2008) M. L. Woolley et al.   PSYCHOPHARMACOLOGY

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

(2008) M DANHOF et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Activation of 5-HT1B and 5-HT1D receptors in the rat nucleus tractus solitarius: opposing action on neurones that receive an excitatory vagal C-fibre afferent input

(2007) R D Jeggo et al.   BRITISH JOURNAL OF PHARMACOLOGY