Article
Biochemical Research Methods
Manuel J. Marques, Michael R. Hughes, Adrian F. Uceda, Grigory Gelikonov, Adrian Bradu, Adrian Podoleanu
Summary: This paper introduces a method of converting a 1D scanning probe into a 2D scanning probe by manual scanning, allowing for real-time imaging and motion correction in forward-viewing optical coherence tomography (OCT) and fluorescence imaging. The approach is capable of handling out-of-plane motion at relatively high speeds.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Multidisciplinary Sciences
Patrick Kilcullen, Tsuneyuki Ozaki, Jinyang Liang
Summary: SPI-ASAP combines DMD with laser scanning hardware to achieve high-speed pattern projection and tunable frame sizes. It also utilizes a lightweight CS reconstruction algorithm for real-time high frame rate video streaming. SPI-ASAP allows reconfigurable imaging, adapts to strong ambient light, and enables high-speed offline imaging.
NATURE COMMUNICATIONS
(2022)
Article
Ophthalmology
Archana A. Nair, Rebecca Liebenthal, Shefali Sood, Grant L. Hom, Marc E. Ohlhausen, Thais F. Conti, Carolina C. S. Valentim, Hiroshi Ishikawa, Gadi Wollstein, Joel S. Schuman, Rishi P. Singh, Yasha S. Modi
Summary: This study utilized NIR-OCT to establish the position of the fovea centralis relative to the optic nerve in healthy individuals and found significant differences between the right and left eyes. It highlights the importance of preoperative and postoperative NIR-OCT scans for assessing true foveal ectopia.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Z. H. E. N. G. Y. U. DUAN, K. A. HUANG, Z. H. O. N. G. Z. H. O. U. LUO, K. E. MA, G. E. N. G. Y. U. A. N. WANG, X. I. A. O. D. O. N. G. HU, J. I. N. Z. E. ZHANG, X. I. A. O. L. I. N. G. LUO, Y. U. A. N. C. O. N. G. HUANG, G. A. N. G. J. U. N. LIU, X. I. A. O. Y. A. N. DING, P. E. N. G. XIAO, J. I. N. YUAN
Summary: We have developed a portable boom-type ophthalmic UHR-OCT system that can be used for high-resolution retinal examinations in pediatric, bedridden, and perioperative patients. The system integrates real-time iris display and automatic focusing, and has high mobility and stability.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Ophthalmology
Yuna Uechi, Kentaro Nakamura, Masato Shinozuka, Shohei Kawasaki, Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: This study evaluated the repeatability of macular hole diameter measurement on en face slab optical coherence tomography (OCT) reflectance images and found that it is closely associated with visual acuity. The results showed that the macular hole diameter measured by our method is highly reproducible compared to the conventional method and is closely correlated with visual acuity.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Derong Hu, Lingjiao Pan, Xinjian Chen, Shuyan Xiao, Quanyu Wu
Summary: This paper proposes a novel method for detecting blood vessels in pathological OCT fundus images. The method reduces pathological interference using an automatic localization and filling method in the preprocessing step. By applying a pore ablation method based on the capillary bundle model, the interference caused by diseased blood vessels can be eliminated to a great extent. The proposed method achieves promising results in DICE, PRECISION, and TPR measures.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Tianqi Liu, Peipei Tao, Xiaolin Wang, Hongqing Wang, Minfei He, Qianqian Wang, Hao Cui, Jianlong Wang, Yaping Tang, Jin Tang, Ning Huang, Cuifang Kuang, Hong Xu, Xiangming He
Summary: Researchers have developed a printing technology that can achieve nanoscale structures at a significantly faster speed than conventional methods. The key to this breakthrough is the use of an extremely sensitive photoresist material. By utilizing this material, the team was able to fabricate high-precision patterns with small line widths, suggesting that this technology has the potential for large-scale additive manufacturing at the nanoscale.
NATURE NANOTECHNOLOGY
(2023)
Article
Optics
Guogang Cao, Sicheng Li, Shu Zhang, Zeyu Peng, Yan Wu, Dong Wang, Cuixia Dai
Summary: Optical Coherence Tomography (OCT) is widely used for high-resolution endoscopic imaging in endoluminal organs. However, Non-Uniform Rotational Distortion (NURD) is a common problem in OCT endoscopic imaging. Two main approaches, hardware-based and algorithm-based, are used for NURD correction. The proposed algorithm-based method utilizes coarse and fine registration, with an improved FAST algorithm, to effectively correct NURD without propagation. Experimental results show higher similarity and better noise suppression in OCTA data compared to other algorithms such as SIFT and SURF. The image registration-based algorithm significantly reduces NURD propagation between B-scan frames and improves the imaging quality of OCT endoscopic images.
Article
Biochemical Research Methods
Jason Zhang, Tan Nguyen, Benjamin Potsaid, Vijaysekhar Jayaraman, Christopher Burgner, Siyu Chen, Jinxi Li, Kaicheng Liang, Alex Cable, Giovanni Traverso, Hiroshi Mashimo, James G. Fujimoto
Summary: This study introduces a MEMS-VCSEL SS-OCT technology with A-scan rates of 2.4 and 3.0 MHz, overcoming limitations of optical clock and enabling ultrahigh speed imaging. Through sweep to sweep calibration and resampling, ultrahigh speed structural SS-OCT and OCT angiography of the swine gastrointestinal tract are successfully demonstrated using miniaturized brushless motor probes. MEMS-VCSELs show promise in enabling ultrahigh speed SS-OCT with scalability, low cost, and manufacturability.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Acoustics
Ruiming Kong, Cuixia Dai, Qi Zhang, Lei Gao, Zhuoquan Chen, Yuting Song, Zhengjie Wu, Jiming Wang, Shuo Wang, Hairong Zheng, Teng Ma
Summary: In this study, a tri-modality imaging system integrating ultrasound, optical coherence tomography (OCT), and near-infrared fluorescence (NIRF) was presented for pancreaticobiliary duct imaging. The system showed promising imaging performance in mechanism studies, early diagnosis, and prognosis evaluation of malignant pancreaticobiliary carcinomas. The imaging accuracy was validated by correlating the tomography images with histology results.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Biochemical Research Methods
Chi Zhang, Fan Yang, Fu Wang, Qingyue Tan, Hao He, Su Zhang, Jigang Wu, Shengxian Tu
Summary: A high-speed side-imaging MDS probe is proposed for endoscopic OCT, which utilizes a reflecting micromirror attached to a tiny magnet and driven by a fast-rotating magnetic field to achieve 360-degree side-view scanning. A prototype probe with an outer diameter of 0.89 mm was fabricated, and OCT images of a porcine artery with implanted stent were acquired at a rate of 100 frames per second using the probe. The system sensitivity of the prototype probe was 95 dB, and the axial and lateral resolutions were 10.3 and 39.7 μm, respectively. This high-speed submillimeter MDS-OCT probe offers a promising alternative for intravascular imaging applications.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Ophthalmology
Naoki Takahashi, Kazuko Omodaka, Arata Nakazawa, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori, Masahiro Akiba, Toru Nakazawa
Summary: This study found that the RNFLD angle measured with SS-OCT was more closely associated with the MD slope than other OCT parameters, suggesting that measuring the RNFLD angle with en face OCT images could be effective in evaluating glaucoma progression.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
H. James Deva Koresh, Shanty Chacko, M. Periyanayagi
Summary: The cornea is the outermost layer of the eye that helps focus light rays towards the retinal layer. Lasik surgery corrects irregular corneal thickness with the need for pre-surgical planning. This study uses a capsule network algorithm to identify the boundaries of the corneal layer through preprocessing, classification, and segmentation stages. Performance of the proposed algorithm is verified against several classification and segmentation techniques.
PATTERN RECOGNITION LETTERS
(2021)
Article
Multidisciplinary Sciences
Xianglei Liu, Artiom Skripka, Yingming Lai, Cheng Jiang, Jingdan Liu, Fiorenzo Vetrone, Jinyang Liang
Summary: The article introduces a method for wide-field video-rate upconversion temperature sensing using compressive sensing technology, which enables video temperature measurement on dynamic samples.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Wenyu Wang, Gongpeng Sun, Lu He, Changzheng Chen
Summary: This study used SS-OCTA and en face OCT to quantitatively analyze macrophage-like cells (MLCs) at the vitreoretinal interface in retinal vein occlusion (RVO). The results showed a significant increase in MLC density in both acute and chronic RVO eyes, indicating the activation and recruitment of MLCs in RVO. Furthermore, the distribution of MLCs can be affected by retinal edema.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ya-Wen Lo, Alan Yueh-Luen Lee, Yi-Ching Liu, Hui-Hsin Ko, Hsin-Hui Peng, Hsiang-Chieh Lee, Pei-Yao Pan, Chun-Pin Chiang, Shih-Jung Cheng
Summary: The study revealed a significant increase in MDSC levels in OSCC patients, which decreased significantly after beta-glucan treatment. Patients receiving beta-glucan treatment showed higher recurrence-free survival rates.
Review
Medicine, Research & Experimental
Steven Char, Ross A. Barman, Timothy R. Deer, Jonathan M. Hagedorn
Summary: Chronic neuropathic groin pain is a challenging condition with multiple identified etiologies. Advances in neuromodulation technology, particularly DRG stimulation, have provided benefits for patients with refractory chronic pain. Prospective randomized controlled studies are needed to further evaluate the effectiveness of DRG stimulation for chronic groin pain.
Editorial Material
Anesthesiology
Ross Barman, Kathryn Clark, Oludare Olatoye
Article
Computer Science, Interdisciplinary Applications
Chao Li, Haibo Jia, Jinwei Tian, Chong He, Fang Lu, Kaiwen Li, Yubin Gong, Sining Hu, Bo Yu, Zhao Wang
Summary: In this study, a fully automated method based on convolutional neural networks (CNN) was proposed to segment and quantify coronary calcification in intravascular OCT (IVOCT) images. The method achieved better results compared to existing state-of-the-art methods and showed close agreement with manual calcification measurements. The proposed method has significant value for automated assessment of coronary calcification lesions and procedure planning.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Biochemical Research Methods
Haoyue Sun, Chen Zhao, Yuhan Qin, Chao Li, Haibo Jia, Bo Yu, Zhao Wang
Summary: In this study, we developed an artificial intelligence method based on deep learning for automated detection of plaque erosion in vivo, which showed good agreement with physicians and can help improve the clinical diagnosis of plaque erosion and develop individualized treatment strategies for ACS patients.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Medicine, General & Internal
Chau Yee Ng, Tai-Ang Wang, Hsiang-Chieh Lee, Bo-Huei Huang, Meng-Tsan Tsai
Summary: Fractional laser treatment is commonly used for dermatological applications. However, observing laser-induced photodamage beneath the tissue surface in vivo is challenging. This study implemented a portable spectral-domain optical coherence tomography (SD-OCT) system to investigate the photodamage induced by CO2 and Nd:YAG lasers in real-time. The correlation between photodamage and exposure energy was analyzed, and the change in optical properties of the damaged tissue was examined. The results demonstrate the potential of OCT for non-invasive evaluation of laser-induced tissue damage and quantitative assessment.
Article
Chemistry, Physical
Yuan Luo, Ming Lun Tseng, Sunil Vyas, Hsin Yu Kuo, Cheng Hung Chu, Mu Ku Chen, Hsiang-Chieh Lee, Wen-Pin Chen, Vin-Cent Su, Xu Shi, Hiroaki Misawa, Din Ping Tsai, Pan-Chyr Yang
Summary: This study demonstrates the application of an abrupt autofocusing beam generated by a nanophotonic metasurface in the field of biomedical research. By selectively delivering optical energy to specific locations, including mouse cardiac samples and ex vivo swine skin tissue, this technology shows great potential for miniature laser surgery instruments.
Review
Clinical Neurology
Ryan S. D'Souza, Ross Barman, Amira Joseph, Alaa Abd-Elsayed
Summary: This article evaluates the evidence for conservative, pharmacological, and neuromodulation treatments for painful diabetic neuropathy (PDN). It is found that intensive glycemic control with insulin may reduce the risk of distal symmetric polyneuropathy in patients with type 1 diabetes. First-line pharmacological treatments for PDN include gabapentinoids and duloxetine.
CURRENT PAIN AND HEADACHE REPORTS
(2022)
Article
Biology
Wentao Zhao, Zhe Zhang, Zhao Wang, Yan Guo, Jun Xie, Xinying Xu
Summary: Accurately localizing the center of specific biological structures in medical images is crucial for clinical treatment. This paper proposes a deep network called ECLNet for localizing eye-related structures by utilizing a method called Adaptive Gaussian Ellipse Heatmap (AGEH). The results show that the proposed method outperforms state-of-the-art methods in terms of performance.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Anesthesiology
Shravani Durbhakula, Serkan Toy, Carlos A. Acosta, Ross A. Barman, Andrew F. Kelner, Mohammad A. Issa, Mustafa Y. Broachwala, Bryan J. Marascalchi, Yeshvant A. Navalgund, Daniel J. Pak, Erika A. Petersen, Neel D. Mehta, Susan M. Moeschler, Lynn R. Kohan
Summary: This study investigates the development, effectiveness, and feasibility of a new spinal cord stimulation (SCS) digital curriculum for pain medicine trainees. The curriculum aims to address the variability in SCS education and equip physicians with SCS expertise. The results show that the curriculum significantly improves knowledge scores for the participants.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Biochemical Research Methods
Guangqian Yang, Kaiwen Li, Jinhan Yao, Shuimiao Chang, Chong He, Fang Lu, Xiaogang Wang, Zhao Wang
Summary: The early assessment of angle closure is crucial for timely diagnosis and treatment of primary angle-closure glaucoma (PACG). This study developed a deep learning method using anterior segment optical coherence tomography (AS-OCT) to automatically detect iris root (IR) and scleral spur (SS) in AS-OCT images and accurately measure anterior chamber (AC) angle parameters. The proposed method achieved better performance than state-of-the-art methods for AS-OCT analysis and demonstrated its potential in pre- and post-operative management of PACG.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Medicine, General & Internal
Ross Barman, Jack McHugh, Thomas O'Mara, Thomas Pittelkow, Ryan S. D'Souza
Summary: Postdural puncture headache is a common complication following procedures such as lumbar puncture, neuraxial anesthesia, or intrathecal drug delivery device implantation. It often presents as a painful orthostatic headache exacerbated by upright position. Conservative therapies are usually tried, but refractory cases may require intervention with an epidural blood patch, which remains the gold standard treatment.
CASE REPORTS IN MEDICINE
(2023)
Article
Oncology
Yi-Jie Lu, Yi-Ting Deng, Hui-Hsin Ko, Hsin-Hui Peng, Hsiang-Chieh Lee, Mark Yen-Ping Kuo, Shih-Jung Cheng
Summary: LOXL2 expression is significantly associated with clinical stage, lymph node metastasis, and overall survival time in oral squamous cell carcinoma (OSCC). Overexpression of LOXL2 enhances migration, invasion, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) phenotypes, independent of its enzymatic activity. LOXL2 also increases the levels of IFIT1 and IFIT3, which are key downstream components of LOXL2 action in migration, invasion, EMT, and CSC phenotypes.
Article
Engineering, Electrical & Electronic
Bo-Yuan Lee, Chih-Hsien Cheng, Cheng-Ting Tsai, Huang-Shen Lin, Shih-Chun Kao, Patrick Chiang, Hsiang-Chieh Lee, Tien-Tsorng Shih, Hao-Chung Kuo, Gong-Ru Lin
Summary: A silicon (Si) Mach-Zehnder modulator (MZM) is used for 10-km SMF Link at C-band (1550 nm) to enable 50 GBaud (100 Gbit/s) per channel pre-emphasized 4-level pulse amplitude modulation (PAM-4) data transmission. The PAM-4 data is encoded onto the Si MZM, compensating for channel dispersion-induced power fading. The Si MZM device exhibits lower power consumption and circuit complexity, making it suitable for 50-GBaud PAM-4 data applications between data centers.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Review
Integrative & Complementary Medicine
Amira E. Joseph, Rajat N. Moman, Ross A. Barman, Donald J. Kleppel, Nathan D. Eberhart, Danielle J. Gerberi, M. Hassan Murad, W. Michael Hooten
Summary: Slow deep breathing may help alleviate acute pain, with a more significant effect observed in burn pain. However, there is limited research evidence, and further studies are needed to determine patient selection and optimize this therapy.
JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE
(2022)
