Article
Endocrinology & Metabolism
Kevin D. Cravedi, Matthew D. May, Jordan A. Abettan, Kylie A. Huckleberry, Sean G. Trettel, Chau V. Vuong, Daniel E. Altman, Sangeeta Gauchan, Rebecca M. Shansky, Liana M. Matson, Jason C. Sousa, Emily G. Lowery-Gionta, Nicole L. T. Moore
Summary: This study investigated the impact of different stressors on organismal responses, revealing that distinct stressors elicit unique patterns of behavioral, neuroendocrine, and neurostructural responses.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychiatry
Chun S. Zuo, Katherine A. Davis, Madeline K. Kuppe, M. Kathryn Dahlgren, Staci Gruber, Garrett M. Fitzmaurice, Scott E. Lukas
Summary: Withdrawal symptoms in cannabis users may be associated with changes in the endocannabinoid system. Magnetic resonance spectroscopy revealed elevated levels of striatal Glx in cannabis users and a correlation between baseline striatal GABA concentration and withdrawal symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Ehsan Hosseini, Mahsa Farid Habibi, Shirin Babri, Gisou Mohaddes, Hajar Abkhezr, Hamed Heydari
Summary: This study investigates the effects of prenatal stress and extremely low frequency electromagnetic fields (ELF-EMF) exposure on anxiety-like behavior and related pathways in the hippocampus of female rat offspring. The results show that ELF-EMF can induce anxiety-like behavior, which may be due to an increase in the PNMDAr2/NMDAr2 ratio and 24(S)-OHC in the hippocampus. Prenatal stress may contribute to anxiety through a decrease in serotonin and an increase in corticosterone in the hippocampus. Additionally, the study suggests that anxiety-like behavior induced by maternal stress exposure is exacerbated by electromagnetic fields radiation.
Article
Neurosciences
Nikhilesh P. Paliwal, Brijesh G. Taksande, Shirish P. Jain, Sachin P. Borikar
Summary: This study aims to investigate the pharmacological interactions between agmatine and gamma aminobutyric acid (GABA) modulatory agents in the regulation of anxiety-like behavior in rats. The results indicate that the anxiolytic effect of agmatine is mediated through GABAergic mechanisms, possibly conciliated by the GABAA receptor subtypes. Therefore, modulation of the interplay between agmatine and GABAA receptor activity may be a significant solution for the regulation of anxiety.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Neurosciences
Sophia Khom, Larry Rodriguez, Pauravi Gandhi, Dean Kirson, Michal Bajo, Christopher S. Oleata, Leandro F. Vendruscolo, Barbara J. Mason, Marisa Roberto
Summary: This study revealed the regulatory mechanism of glucocorticoid receptors on GABA transmission at synapses in the central nucleus of the amygdala, providing important insights for finding potential drugs for the treatment of alcohol use disorder.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Akbar Hajizadeh Moghaddam, Mohammad Amin Mashayekhpour, Mohaddeseh Abouhosseini Tabari
Summary: The study examined the anxiolytic activities of citral in mice and found that it exerted its effects through modulation of the GABA(A) and 5-HT1A receptors.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Raquel Cardoso Brito, Thairyne Olivato, Takae Tamy Kitabatake, Kelly Zhang, Elaine Caldeira de Oliveira Guirro, Joao Eduardo de Araujo
Summary: Studies have found that psychotropic drugs can alter rat behavior in the elevated plus-maze test. This study aimed to investigate whether static magnetic fields could impact alprazolam-induced rat behavior in the same test. The results showed that the south magnetic pole of the static magnetic field blocked the effect of alprazolam on the space-time variables of the open arms and ethological anxiolytic-like behavior in the elevated plus-maze test.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Vandna, Shruti Ahlawat, Krishna Kant Sharma, Hari Mohan
Summary: This study found that the co-administration of ketoprofen with Yersinia enterocolitica can cause significant damage to the rat gut, leading to altered expression of gut proteins and profound effects on the NF-kB signaling pathway, immune system, dysbiosis, and gut injury. Additionally, the biochemical and histopathological analysis of treated rats showed evidence of liver enzyme activity alteration and behavioral response changes, indicating the detrimental effects of the co-administration.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Lauren Gaspar, Sydney Bartman, Giuseppe Coppotelli, Jaime M. Ross
Summary: The incidence of anxiety-like disorders in humans decreases with aging, but it is unclear whether this is also true in mice. Mouse models can be used to understand the changes in neuronal networks that regulate anxiety-like behavior in aging. The elevated plus maze (EPM) test is commonly used to assess anxiety-like behavior, but it is unknown how the construction of the apparatus affects the behavior of younger and older mice. This study found that the distance traveled during the EPM test was most affected by the apparatus characteristics, and that old mice spent more time and had more entries in the open arms compared to young mice, suggesting a decrease in anxiety-like behavior with age.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
M. Estrella Fernandez de Sevilla, Jaime Pignatelli, Jonathan A. Zegarra-Valdivia, Pablo Mendez, Angel Nunez, Ignacio Torres Aleman
Summary: This study reveals that mice lacking functional insulin-like growth factor I (IGF-I) receptors in orexin neurons exhibit PTSD-like behavior and are unresponsive to the anxiolytic effects of IGF-I, while inhibition of orexin neurons improves this behavior. Systemic IGF-I treatment also ameliorates PTSD-like behavior in mice, and IGF-I modulates the GABA/Glutamate synaptic structure in orexin neurons to achieve this effect.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Hirotaka Shoji, Tsuyoshi Miyakawa
Summary: The study explored the effects of different test conditions on behavior and plasma corticosterone responses in male C57BL/6J mice in the elevated plus maze test. It found that experience with other behavioral tests and different physical features of the maze can influence behavior in the test.
Article
Behavioral Sciences
Nicolas Cordeiro, Jose Augusto Pochapski, William Sanchez Luna, Gabriel Baltazar, Rainer K. Schwarting, Roberto Andreatini, Claudio Da Cunha
Summary: Ultrasonic vocalizations play a role in conveying emotional states in both young pups and adult rats, with differences observed between genders and developmental stages. Pup vocalizations can predict adult behaviors, while adult vocalizations are influenced by stimulants.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Psychology, Biological
Patricia Gonzalez-Gaspar, Monserrat Macias-Carballo, Teresa Cadena-Mejia, Miguel A. Landa-Jimenez, Fernando M. Montes-Gonzalez, Maria Leonor Lopez-Meraz, Luis Beltran-Parrazal, Consuelo Morgado-Valle
Summary: Analixity is a video processing software designed for the elevated plus maze test (EPM) that automatically quantifies behavioral parameters, reducing analysis time and variability issues. Comparison with manual analysis and a commercial software showed that Analixity is as reliable and effective as the latter.
BEHAVIOURAL PROCESSES
(2021)
Editorial Material
Pharmacology & Pharmacy
Francisco Ciruela, Kjell Fuxe, Peter Illes, Henning Ulrich, Francesco Caciagli
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Laura Garcia-Duran, Noelia Cantero-Garcia, Araceli Puigcerver, Jose Angel Narvaez, Kjell Fuxe, Luis Santin, Zaida Diaz-Cabiale
Summary: The study revealed that GAL(1-15) enhances the antidepressant effects of FLX in a depression animal model, potentially mediated through 5-HT1AR. This opens up the possibility of using a combination of GAL(1-15) and FLX as a novel treatment strategy for depression.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Dasiel O. Borroto-Escuela, Luca Ferraro, Kjell Fuxe
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dasiel O. Borroto-Escuela, Ramon Fores, Mariana Pita, Miguel A. Barbancho, Pablo Zamorano-Gonzalez, Natalia Garcia Casares, Kjell Fuxe, Manuel Narvaez
Summary: This study assesses the effects of GALR2 and NPYY1R agonists coadministration on sustained memory and hippocampal cell proliferation, suggesting the potential therapeutic benefits for dementia conditions and memory deficits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Noelia Cantero-Garcia, Antonio Flores-Burgess, David Ladron de Guevara-Miranda, Antonia Serrano, Laura Garcia-Duran, Araceli Puigcerver, Kjell Fuxe, Jose Angel Narvaez, Luis Javier Santin, Zaida Diaz-Cabiale, Carmelo Millon
Summary: This study analyzed the effect of GAL(1-15) on alcohol consumption and depression treatment. The combination of GAL(1-15) and ESC significantly reduced alcohol intake and enhanced ESC's reduction of reward capacity. Additionally, GAL(1-15) reversed the adverse effects of ESC in depression-related behavioral tests and forced swimming tests in rats.
Review
Cell Biology
Miguel Perez de la Mora, Dasiel O. Borroto-Escuela, Minerva Crespo-Ramirez, Jose del Carmen Rejon-Orantes, Daniel Alejandro Palacios-Lagunas, Magda K. Martinez-Mata, Daniela Sanchez-Luna, Emiliano Tesoro-Cruz, Kjell Fuxe
Summary: Major depressive disorder (MDD) and anxiety are highly prevalent mental diseases with negative impacts on society and patients. Finding effective treatments with limited side effects is an important goal. This review focuses on the role of G-protein coupled receptors (GPCRs), such as serotonin, dopamine, galanin, and opioid heteroreceptor complexes, in regulating synaptic transmission in the limbic networks of the brain, and how understanding these mechanisms can contribute to the development of new treatments for MDD and anxiety disorders.
Article
Biochemistry & Molecular Biology
Marina Mirchandani-Duque, Miguel A. Barbancho, Alexander Lopez-Salas, Jose Erik Alvarez-Contino, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study evaluated the role of neuropeptide Y and galanin in hippocampal neurogenesis and found that they improve spatial memory by promoting cell proliferation and inducing neuroprotective factors. This finding provides a potential novel therapy for neurodegenerative cognitive-affecting diseases.
Article
Behavioral Sciences
Martin Migliaro, Rodolfo Sanchez-Zavaleta, Eva Soto-Tinoco, Alejandra E. Ruiz-Contreras, Monica Mendez-Diaz, Andrea Herrera-Solis, Miguel Perez de la Mora, Oscar E. Prospero-Garcia
Summary: This study reveals distinct differences in the rewarding effects of psychostimulants between dominant and subordinate individuals. Additionally, it demonstrates the association between the expression of CB1R and behavioral phenotypes related to social dominance.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Cell Biology
Jose Erik Alvarez-Contino, Estela Diaz-Sanchez, Marina Mirchandani-Duque, Jose Andres Sanchez-Perez, Miguel A. Barbancho, Alexander Lopez-Salas, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study found that intranasal infusion of GALR2 and Y1R agonists promotes neuroblast proliferation and induces the expression of the neurotrophic factor BDNF in the ventral hippocampus, resulting in antidepressant effects. These effects may be mediated by increased formation of Y1R-GALR2 heteroreceptor complexes. These findings may provide a new approach for the development of novel therapies for major depressive disorder.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Clinical Neurology
Rodolfo Sanchez-Zavaleta, Jose Segovia, Alejandra E. Ruiz-Contreras, Andrea Herrera-Solis, Monica Mendez-Diaz, Miguel Perez De la Mora, Oscar E. Prospero-Garcia
Summary: The activation of GPR55 in the ventral hippocampus prevents the inflammatory response induced by amphetamine and the conditioned place preference. This suggests that GPR55 plays a crucial role in preventing the rewarding effects of amphetamine.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Patrizia Ambrogini, Davide Lattanzi, Marica Pagliarini, Michael Di Palma, Stefano Sartini, Riccardo Cuppini, Kjell Fuxe, Dasiel Oscar Borroto-Escuela
Summary: This study investigates the effects of 5HT1AR-FGFR1 complex activation on hippocampal pyramidal neurons and midbrain dorsal raphe serotonergic neurons using an electrophysiological approach. The results show that in normal rats, FGFR1 agonist-induced allosteric action counteracts the ability of 5HT1AR to open GIRK channels, leading to increased neuronal firing. However, in a depression rat model, the change in 5HT1AR caused by FGFR1 does not affect the GIRK channels, except in CA2 neurons. Therefore, the reduced inhibitory ability of FGFR1 on 5HT1AR-mediated GIRK channel opening may be associated with depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Rodolfo Sanchez-Zavaleta, Lorena Alline Becerril-Melendez, Alejandra E. Ruiz-Contreras, Ana Paula Escobar-Elias, Andrea Herrera-Solis, Monica Mendez-Diaz, Miguel Perez de la Mora, Oscar E. Prospero-Garcia, Grupo Neurociencias
Summary: The study found that different patterns of drug ingestion have a different impact on the brain and the development of drug addiction. The effects of continuous low doses and intermittent high doses of ACEA on amphetamine seeking and ingestion were compared, as well as the expression of CB1R and CRFR1 in the amygdala and nucleus accumbens shell. The results showed that binge-like ingestion of drugs induced changes in the brain and increased vulnerability to drug addiction.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Juan Carlos Hernandez-Mondragon, Dexter A. Hernandez-Hernandez, Minerva Crespo-Ramirez, Oscar Prospero-Garcia, Luisa Rocha-Arrieta, Kjell Fuxe, Dasiel O. Borroto-Escuela, Miguel Perez de la Mora
Summary: Enhancing the interaction between dopamine D2 receptors (D2Rs) and oxytocin receptors (OXTRs) in the central amygdala may enhance anxiolytic effects. The coadministration of oxytocin and a D2R agonist improved the anxiolytic effects in rats. In situ proximity ligation assay and BRET2 assay provided evidence for the existence of D2R-OXTR heterocomplexes.
FRONTIERS IN PHARMACOLOGY
(2023)
