Article
Neurosciences
Kaixiu Li, Xiaoqi Li, Qun Wang, Liqiang Wang, Yifei Huang
Summary: This study compared the kinetic pupillary changes between high myopia and low/moderate myopia using Pentacam. The results showed that in certain scanning periods, the pupillary changes in high myopia patients were slower compared to low/moderate myopia patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Biological
Xiangyong Yuan, Yuhui Cheng, Yi Jiang
Summary: This study investigated the pupillary response to light in a multisensory context, finding that the oscillation of pupil size induced by light flicker was substantially attenuated when bright light was presented synchronously with tones. This inhibition effect persisted even when the visual flicker was task-irrelevant and out of attentional focus, but disappeared when the visual stimulus was moved from the central field to the periphery.
Article
Multidisciplinary Sciences
Sooyeoun You, Jeong-Ho Hong, Joonsang Yoo
Summary: The study conducted pupillometer testing on Parkinson's disease patients, divided into early and late-stage groups. The results showed that the early group had significantly faster pupil constriction velocity compared to the late group, while other parameters were similar.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Frederick Robert Carrick, Sergio F. Azzolino, Melissa Hunfalvay, Guido Pagnacco, Elena Oggero, Ryan C. N. D'Arcy, Mahera Abdulrahman, Kiminobu Sugaya
Summary: The pupillary light reflex (PLR) is modulated by cognitive brain function and can be affected by long-term changes in brain function due to injury. PLR variables such as latency, pupil diameter, constriction velocity, and recovery time show significant differences between subjects with and without concussion history, as well as differences related to gender and symptoms. These differences suggest that PLR metrics can serve as biomarkers for clinical diagnosis and decision making in individuals with concussive injuries.
Review
Computer Science, Interdisciplinary Applications
Hedenir Monteiro Pinheiro, Ronaldo Martins da Costa
Summary: This study thoroughly reviews publications on pupillary light reflex (PLR) used for aiding diagnoses, focusing on computational techniques and their application in computer-aided diagnoses (CAD) of pathologies or physiological conditions related to miosis and mydriasis of the human pupil. A detailed survey of studies from the past 10 years was conducted, covering electronic devices, recording protocols, image treatment, computational algorithms, and pathologies associated with PLR. The field is continuously expanding with the potential to perform diagnoses with high precision, low cost, and non-invasively.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Biophysics
Hiroatsu Hatsukawa, Masaaki Ishikawa
Summary: This study aimed to investigate the potential of pupillary light reflex and heart rate variability parameters as objective indicators of subjective pain intensity after tonsillectomy. The results showed significant changes in initial pupil size and constriction latency within the first two days postoperatively, with constriction latency being a robust indicator of subjective pain intensity.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Multidisciplinary Sciences
Hugo Mitre-Hernandez, Jorge Sanchez-Rodriguez, Sergio Nava-Munoz, Carlos Lara-Alvarez
Summary: This study classifies memorization tasks of different difficulty levels using pupillary response data, finding significant differences in pupillometric features for different levels of difficulty, and successfully evaluates task cognitive load using a random forest classifier.
Article
Neurosciences
Jan Willem de Gee, Camile M. C. Correa, Matthew Weaver, Tobias H. Donner, Simon van Gaal
Summary: The study demonstrates that pupil responses and slow wave event-related potential, as physiological markers of phasic arousal, both reflect surprise in decision-making under uncertainty. Furthermore, these two variables are unrelated to each other, and prediction error computations depend on feedback awareness.
Article
Ophthalmology
Xiaoyin Zhou, Hisashi Fukuyama, Yoichi Okita, Hiroyuki Kanda, Yuki Yamamoto, Takashi Araki, Fumi Gomi
Summary: This study assessed the autonomic nervous system in patients with central serous chorioretinopathy (CSC) by measuring pupillary responses and heart rate variability (HRV). The results indicated parasympathetic inhibition and sympathetic activation in CSC patients, as well as larger pupil dilation during mental tasks, which could be a potential marker of psychophysiological stress.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Xiaoyin Zhou, Hisashi Fukuyama, Takaaki Sugisawa, Yoichi Okita, Hiroyuki Kanda, Yuki Yamamoto, Takashi Araki, Fumi Gomi
Summary: This study investigated and compared the pupillary response between acute and chronic central serous chorioretinopathy (CSC), as well as different disease categories. The results showed differences in pupillary response between the acute and chronic CSC groups, and the pupillary response was associated with retinal/choroidal architecture.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Hilal Kilinc Hekimsoy, Mehmet Ali Sekeroglu, Nurtac Yesilyaprak, Sibel Doguizi, Pelin Yilmazbas
Summary: This study evaluated the prevalence of physiological anisocoria in healthy subjects under various lighting conditions and compared the dynamic pupillometric measurements of patients with physiological anisocoria. The results showed that smaller pupils of anisocoric patients had lower contraction amplitude and velocity compared to larger pupils.
Article
Biochemistry & Molecular Biology
Gianina Ungurean, Dolores Martinez-Gonzalez, Bertrand Massot, Paul-Antoine Libourel, Niels C. Rattenborg
Summary: Mammalian pupils respond to various stimuli and reflect the state of the brain. In contrast, pigeons exhibit different pupil behaviors during wakefulness and sleep, potentially due to differences in iris muscle composition and control mechanisms between birds and mammals.
Article
Ophthalmology
Carina Kelbsch, Ricarda Jendritza, Torsten Strasser, Felix Tonagel, Paul Richter, Ronja Jung, Tobias Peters, Helmut Wilhelm, Barbara Wilhelm, Krunoslav Stingl
Summary: The study aimed to investigate pupil redilation during persistent light exposure at the macula and periphery with monochromatic light stimuli. Forty healthy subjects were examined using chromatic pupil campimetry, and the results showed a distinct pupillary escape phenomenon in the periphery, but not in the central healthy retina. The escape was more pronounced for red stimulation compared with blue stimulation in the periphery. The results suggest that an intact inner retinal network is necessary for maintaining pupillary constriction and preventing pupillary escape during bright light stimulation.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Psychology, Biological
Masaaki Ishikawa, Hiroatsu Hatsukawa
Summary: This study investigated the potential of INIT/LAT as objective indicators of mental fatigue in surgical patients. The results showed that INIT and LAT were associated with mental fatigue and both should be used as indicators.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Biological
Annika Ziereis, Anne Schacht
Summary: Social and emotional cues from faces and voices have been shown to involuntarily attract attention. This study aimed to investigate the automatic association of emotional valence with neutral faces. During the learning session, participants performed a gender-matching task on face-voice pairs without explicit emotion judgments. Results showed that task-irrelevant emotion was automatically processed, but the task-relevant information of gender congruence had a stronger impact on event-related potentials and response times.
Article
Psychology, Clinical
E. Fonseca-Pedrero, M. Debbane, J. Ortuno-Sierra, R. C. K. Chan, D. C. Cicero, L. C. Zhang, C. Brenner, E. Barkus, R. J. Linscott, T. Kwapil, N. Barrantes-Vidal, A. Cohen, A. Raine, M. T. Compton, E. B. Tone, J. Suhr, J. Muniz, A. Fumero, S. Giakoumaki, I. Tsaousis, A. Preti, M. Chmielewski, J. Laloyaux, A. Mechri, M. A. Lahmar, V. Wuthrich, F. Laroi, J. C. Badcock, A. Jablensky
PSYCHOLOGICAL MEDICINE
(2018)
Article
Psychiatry
Alex Hatzimanolis, Dimitrios Avramopoulos, Dan E. Arking, Anna Moes, Pallav Bhatnagar, Todd Lencz, Anil K. Malhotra, Stella G. Giakoumaki, Panos Roussos, Nikolaos Smyrnis, Panos Bitsios, Nicholas C. Stefanis
SCHIZOPHRENIA BULLETIN
(2018)
Article
Psychiatry
Boris B. Quednow, Kenechi Ejebe, Michael Wagner, Stella G. Giakoumaki, Panos Bitsios, Veena Kumari, Panos Roussos
SCHIZOPHRENIA RESEARCH
(2018)
Article
Psychiatry
Eduardo Fonseca-Pedrero, Javier Ortuno, Martin Debbane, Raymond C. K. Chan, David Cicero, Lisa C. Zhangs, Colleen Brenner, Emma Barkus, Richard J. Linscott, Thomas Kwapil, Neus Barrantes-Vidal, Alex Cohen, Adrian Raine, Michael T. Compton, Erin B. Tones, Julie Suhr, Felix Inchausti, Julio Bobes, Axit Fumero, Stella Giakoumaki, Ioannis Tsaousis, Antonio Preti, Michael Chmielewski, Julien Laloyaux, Anwar Mechri, Mohamed Aymen Lahmar, Viviana Wuthrich, Frank Laroi, Johanna C. Badcock, Assen Jablensky, Adela M. Isvoranu, Sacha Epskamp, Eiko Fried
SCHIZOPHRENIA BULLETIN
(2018)
Article
Genetics & Heredity
Max Lam, Joey W. Trampush, Jin Yu, Emma Knowles, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, Astri J. Lundervold, Vidar M. Steen, Thomas Espeseth, Katri Raikkonen, Elisabeth Widen, Aarno Palotie, Johan G. Eriksson, Ina Giegling, Bettina Konte, Panos Roussos, Stella Giakoumaki, Katherine E. Burdick, Antony Payton, William Ollier, Ornit Chiba-Falek, Deborah K. Attix, Anna C. Need, Elizabeth T. Cirulli, Aristotle N. Voineskos, Nikos C. Stefanis, Dimitrios Avramopoulos, Alex Hatzimanolis, Dan E. Arking, Nikolaos Smyrnis, Robert M. Bilder, Nelson A. Freimer, Tyrone D. Cannon, Edythe London, Russell A. Poldrack, Fred W. Sabb, Eliza Congdon, Emily Drabant Conley, Matthew A. Scult, Dwight Dickinson, Richard E. Straub, Gary Donohoe, Derek Morris, Aiden Corvin, Michael Gill, Ahmad R. Hariri, Daniel R. Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C. Keller, Ole A. Andreassen, David C. Glahn, Anil K. Malhotra, Todd Lencz
TWIN RESEARCH AND HUMAN GENETICS
(2018)
Article
Multidisciplinary Sciences
Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloe Fawns-Ritchie, David C. M. Liewald, Judith A. Okely, Ari V. Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E. Gustavson, Caroline Hayward, Edith Hofer, M. Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A. Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A. Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A. Smith, Albert V. Smith, Natalie Terzikhan, Anbupalam Thalamuthu, Stella Trompet, Sven J. van der Lee, Erin B. Ware, B. Gwen Windham, Margaret J. Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A. Andreassen, Nicola J. Armstrong, Amelia A. Assareh, John R. Attia, Deborah Attix, Dimitrios Avramopoulos, David A. Bennett, Anne C. Boehmer, Patricia A. Boyle, Henry Brodaty, Harry Campbell, Tyrone D. Cannon, Elizabeth T. Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R. Cox, Anders M. Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G. Eriksson, Evangelos Evangelou, Jessica D. Faul, Ian Ford, Nelson A. Freimer, He Gao, Ina Giegling, Nathan A. Gillespie, Scott D. Gordon, Rebecca F. Gottesman, Michael E. Griswold, Vilmundur Gudnason, Tamara B. Harris, Annette M. Hartmann, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G. Holliday, Peter K. Joshi, Mika Kahonen, Sharon L. R. Kardia, Ida Karlsson, Luca Kleineidam, David S. Knopman, Nicole A. Kochan, Bettina Konte, John B. Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimaki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T. Longstreth, Oscar L. Lopez, Anu Loukola, Tobias Luck, Astri J. Lundervold, Anders Lundquist, Leo-Pekka Lyytikainen, Nicholas G. Martin, Grant W. Montgomery, Alison D. Murray, Anna C. Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A. Poldrack, Bruce M. Psaty, Simone Reppermund, Steffi G. Riedel-Heller, Richard J. Rose, Jerome I. Rotter, Panos Roussos, Suvi P. Rovio, Yasaman Saba, Fred W. Sabb, Perminder S. Sachdev, Claudia L. Satizabal, Matthias Schmid, Rodney J. Scott, Matthew A. Scult, Jeannette Simino, P. Eline Slagboom, Nikolaos Smyrnis, Aicha Soumare, Nikos C. Stefanis, David J. Stott, Richard E. Straub, Kjetil Sundet, Adele M. Taylor, Kent D. Taylor, Ioanna Tzoulaki, Christophe Tzourio, Andre Uitterlinden, Veronique Vitart, Aristotle N. Voineskos, Jaakko Kaprio, Michael Wagner, Holger Wagner, Leonie Weinhold, K. Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab H. H. Adams, Dan E. Arking, Robert M. Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L. De Jager, Stephanie Debette, Gary Donohoe, Paul Elliott, Annette L. Fitzpatrick, Michael Gill, David C. Glahn, Sara Hagg, Narelle K. Hansell, Ahmad R. Hariri, M. Kamran Ikram, J. Wouter Jukema, Eero Vuoksimaa, Matthew C. Keller, William S. Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L. Pedersen, Neil Pendleton, David J. Porteous, Katri Raikkonen, Olli T. Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W. Schofield, Peter R. Schofield, John M. Starr, Vidar M. Steen, Julian N. Trollor, Steven T. Turner, Cornelia M. Van Duijn, Arno Villringer, Daniel R. Weinberger, David R. Weir, James F. Wilson, Anil Malhotra, Andrew M. McIntosh, Catharine R. Gale, Sudha Seshadri, Thomas H. Mosley, Jan Bressler, Todd Lencz, Ian J. Deary
NATURE COMMUNICATIONS
(2018)
Article
Psychiatry
Chrysoula Zouraraki, Leda Karagiannopoulou, Penny Karamaouna, Eleftherios G. Pallis, Stella G. Giakoumaki
PSYCHIATRY RESEARCH
(2019)
Article
Psychiatry
Stella G. Giakoumaki, Leda Karagiannopoulou, Penny Karamaouna, Chrysoula Zouraraki, Panos Bitsios
COGNITIVE NEUROPSYCHIATRY
(2020)
Article
Cell Biology
Vasiliki Stavroulaki, Stella G. Giakoumaki, Kyriaki Sidiropoulou
Summary: The debate over whether training on working memory tasks can improve memory function and other cognitive abilities remains controversial, with contradictory findings from prior studies. The lack of systematic approaches and methodological shortcomings further complicate the issue.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Review
Psychiatry
Chrysoula Zouraraki, Penny Karamaouna, Stella G. Giakoumaki
Summary: This systematic review aimed to clarify the relationship between schizotypal traits and facial emotion recognition deficits. The findings indicate that individuals with high schizotypal traits and patients with Schizotypal Personality Disorder (SPD) perform poorly in facial emotion recognition tasks. Different dimensions of schizotypy are associated with specific patterns of deficits in emotion recognition. These findings suggest that emotion recognition deficits may serve as trait markers for schizophrenia spectrum disorders and should be targeted in early-intervention programs.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Chrysoula Zouraraki, Andriani Kyriklaki, Elias Economou, Stella G. Giakoumaki
Summary: The present study examined the potential moderating effects of early traumatic experiences on the association between schizotypal traits and visual perceptual processing. The findings revealed that different aspects of schizotypal traits were differently associated with visual illusions depending on the levels of early traumatic experiences.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Vasiliki Stavroulaki, Kyriaki Sidiropoulou, Panos Bitsios, Stella G. Giakoumaki
Summary: This study investigated the far transfer effects of Executive Working Memory (EWM) on cognitive flexibility. The findings showed that participants who received EWM training demonstrated better cognitive flexibility, which is consistent with other studies on working memory training. These findings have promising implications for early intervention programs for individuals with cognitive impairments.
CURRENT PSYCHOLOGY
(2023)
Review
Neurosciences
Chrysoula Zouraraki, Penny Karamaouna, Stella G. Giakoumaki
Summary: Ample research findings suggest altered brain functioning in the schizophrenia spectrum. However, functional neuroimaging findings remain unclear for individuals with high schizotypal traits and diagnosed with schizotypal personality disorder (SPD). This systematic review aimed to identify neural abnormalities in task-related and resting-state conditions across these groups. The review found functional alterations in striatal, frontal, and temporal regions in individuals with high schizotypal traits, and default mode network abnormalities in SPD patients. Further research is needed to understand the neural correlates and compensatory mechanisms in these conditions.
Article
Clinical Neurology
Penny Karamaouna, Chrysoula Zouraraki, Elias Economou, Konstantinos Kafetsios, Panos Bitsios, Stella G. Giakoumaki
Summary: This study examines the cold and hot executive function processes in individuals with different schizotypal traits. The results indicate that there is no categorical association between the dimensions of schizotypy and cold or hot executive function processes, and impoverished emotional intelligence is a core feature of schizotypy.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychology, Multidisciplinary
Stella G. Giakoumaki, Penny Karamaouna, Leda Karagiannopoulou, Chrysoula Zouraraki
Summary: The critical link between schizotypy and schizophrenia is the impoverished cognitive functioning. Different schizotypal dimensions are associated with different patterns of self-perceived cognitive lapses, with negative schizotypy being characterized by generalized cognitive failures and disorganized schizotypy showing specific cognitive slips related to fronto-parietal network functioning. Psychological well-being is negatively associated with negative schizotypy but positively associated with cognitive-perceptual schizotypy.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2021)