Article
Pharmacology & Pharmacy
Manal E. Alkahtani, Alhassan H. Aodah, Omar A. Abu Asab, Abdul W. Basit, Mine Orlu, Essam A. Tawfik
Summary: The study demonstrated that a fixed-dose combination of quetiapine and escitalopram in a fast-dissolving film formulation could accelerate drug release and enhance oral absorption, providing a potential treatment option for treatment-resistant depression.
Article
Medicine, Research & Experimental
Junliang Jiang, Miaoxian Yang, Mi Tian, Zhong Chen, Lei Xiao, Ye Gong
Summary: Major depressive disorder (MDD) is a prevalent psychiatric disorder, and the COVID-19 pandemic has worsened its prevalence. Oxytocin, an endogenous neuropeptide, has emerged as a potential therapeutic option due to its anxiolytic and antidepressant properties. This review examines the interactions between oxytocin, the immune system, and depressive disorder, and speculates on the potential roles of oxytocin and the central immune system in treating emotional disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Feng Fang, Beata Godlewska, Raymond Y. Cho, Sean I. Savitz, Sudhakar Selvaraj, Yingchun Zhang
Summary: This study investigated the effects of the antidepressant drug escitalopram on functional brain controllability in patients with major depressive disorder (MDD). The results showed that escitalopram treatment improved the brain controllability of MDD patients and predicted improvements in clinical scores.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
John-Jose Nunez, Yang S. Liu, Bo Cao, Benicio N. Frey, Keith Ho, Roumen Milev, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Valerie H. Taylor, Rudolf Uher, Sidney H. Kennedy, Raymond W. Lam
Summary: Depression is a complex disorder with a heterogeneous response to treatment. This study used machine learning to cluster patients with depression and found three distinct response patterns. The subjective mood state/anhedonia was identified as the core feature of response to escitalopram, but there were also other patterns related to neurovegetative symptoms, activation, and cognition.
PSYCHIATRY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Maja Jazvinscak Jembrek, Nada Orsolic, Dalibor Karlovic, Vjekoslav Peitl
Summary: Major depressive disorder is a common mental illness that severely impacts quality of life. In addition to altered monoamine neurotransmission, other neuropathological mechanisms have been identified, including oxidative stress, neuroinflammation, hippocampal atrophy, reduced synaptic plasticity and neurogenesis, depletion of neurotrophic factors, and dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. Flavonols, a class of flavonoids in the human diet, have shown potential as antidepressant agents due to their antioxidative and anti-inflammatory effects, ability to restore HPA axis control, promote neurogenesis, and alleviate depressive-like behavior. However, further studies are needed to evaluate their clinical potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Robin Carhart-Harris, Bruna Giribaldi, Rosalind Watts, Michelle Baker-Jones, Ashleigh Murphy-Beiner, Roberta Murphy, Jonny Martell, Allan Blemings, David Erritzoe, David J. Nutt
Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Psychiatry
Calvin Diep, Norma Rosenek, Yuelee Khoo, Wiebke Gandhi, Carien M. van Reekum, Arun V. Ravindran, Karim S. Ladha, Benicio N. Frey, Roumen V. Milev, Susan Rotzinger, Raymond W. Lam, Sidney H. Kennedy, Wendy Lou, Tim Salomons, Venkat Bhat
Summary: This study investigated the pain-alleviating effects of escitalopram and adjunctive aripiprazole for patients with comorbid pain and depression. The results showed significant improvements in pain severity and interference for patients receiving escitalopram, regardless of treatment response. However, patients receiving aripiprazole after week 8 did not experience further improvement in pain symptoms. Further research is needed to identify interventions that can effectively treat both pain and depression symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Chor Hong Lim, Tomoko Soga, Ishwar S. Parhar
Summary: Social disturbance in interpersonal relationships is a primary source of stress in humans. This study investigated the regulatory relationship between the central 5-HT system and SPX1a gene expression in Nile tilapia. The results showed that 5-HT can down-regulate the expression of SPX1a, and socially defeated tilapia exhibited increased SPX1a expression and up-regulated 5-HT receptors. Citalopram treatment normalized SPX1a gene expression in socially defeated fish.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Psychiatry
Johannes M. Hennings, Marcus Ising, Manfred Uhr, Florian Holsboer, Susanne Lucae
Summary: Suicide leads to over 700,000 deaths worldwide annually, with psychiatric disorders, especially major depression, being the most common cause. Effective methods for preventing suicide attempts in high-risk individuals are lacking. This study found that the neuroendocrine stress response system, known as the hypothalamic-pituitary-adrenocortical (HPA) axis, is disrupted in major depression and suicidality. Individuals with a history of suicide attempts exhibit an attenuated hormonal response to stress. Moreover, patients with multiple previous suicide attempts show increased hormonal response even after recovering from depression. These findings suggest that patients with a history of suicide attempts belong to a distinct subgroup with a different stress hormone response pattern.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Sabrina Neyer, Michael Witthoeft, Mark Cropley, Markus Pawelzik, Stefan Suetterlin, Ricardo G. Lugo
Summary: The replication study confirmed the association between cortisol awakening response and depression severity, but did not reach statistical significance. The results suggest a limited practical relevance of cortisol awakening response measures in this clinical context.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Zhanhua Hu, Jiali Li, Aixiang Xiao, Juntao Zheng, Shaoxing Guan, Jianxiong Guo, Min Huang
Summary: A rapid and sensitive method was established for simultaneous quantification of Escitalopram and its metabolites in human plasma. The method was validated and found to be in compliance with applicable regulations. The plasma concentrations of Escitalopram and its metabolites varied among depressed patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Pharmacology & Pharmacy
Yudan Ding, Zirou Wei, Haohao Yan, Wenbin Guo
Summary: This meta-analysis found that HPA-targeting medications have certain efficacy for MDD patients, especially mifepristone and vasopressin V-1B receptor antagonist treatments are significantly effective, but with more adverse events reported.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychiatry
Mohammad Nadi Sakhvidi, Zanireh Salami, Maryam Mosadegh, Reza Bidaki, Hossien Fallahzadeh, Razie Salehabadi, Malihe Arjmandi
Summary: This study examined the therapeutic efficacy and safety of adding celecoxib to Ecitalopram in the treatment of major depressive disorder. The results showed that adding celecoxib effectively improved depressive symptoms in the intervention group at 4 and 8 weeks after initiating treatment, without increasing treatment-related side effects.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Annette Johansen, Sophia Armand, Pontus Plaven-Sigray, Arafat Nasser, Brice Ozenne, Ida N. Petersen, Sune H. Keller, Jacob Madsen, Vincent Beliveau, Kirsten Moller, Alexandra Vassilieva, Christelle Langley, Claus Svarer, Dea S. Stenbaek, Barbara J. Sahakian, Gitte M. Knudsen
Summary: This study investigated the effects of the SSRI escitalopram on synaptic plasticity. The findings suggest that daily intake of escitalopram for 3-5 weeks can lead to changes in brain synaptic plasticity, providing a biological explanation for the delayed treatment response commonly observed in patients treated with SSRIs.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Peijun Tian, Renying Zou, Luyao Wang, Ying Chen, Xin Qian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Gang Wang, Wei Chen
Summary: This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The results showed that multi-probiotics significantly reduced depression symptoms and improved gastrointestinal functions, with serotonergic system modification as the key mechanism.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Psychiatry
Konstantinos N. Fountoulakis, Xenia Gonda, Thomas C. Baghai, David S. Baldwin, Michael Bauer, Pierre Blier, Wagner Gattaz, Gregor Hasler, Hans-Juergen Moeller, Rajiv Tandon, Eduard Vieta, Siegfried Kasper
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2015)
Article
Clinical Neurology
Nina Sarubin, Sven Hilbert, Felix Naumann, Peter Zill, Anna-Maria Wimmer, Caroline Nothdurfter, Rainer Rupprecht, Thomas C. Baghai, Markus Buehner, Cornelius Schuele
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2017)
Article
Clinical Neurology
A. Manook, A. Hiergeist, R. Rupprecht, T. C. Baghai
Article
Pharmacology & Pharmacy
N. Sarubin, T. C. Baghai, J. M. Lima-Ojeda, D. Melchner, H. Hallof-Buestrich, L. Wolf, S. Hilbert, V. M. Milenkovic, C. H. Wetzel, R. Rupprecht, C. Nothdurfter
PHARMACOPSYCHIATRY
(2016)
Article
Clinical Neurology
Mazda Adli, Katja Wiethoff, Thomas C. Baghai, Robert Fisher, Florian Seemueller, Gregor Laakmann, Peter Brieger, Joachim Cordes, Jaroslav Malevani, Gerd Laux, Iris Hauth, Hans-Juergen Moeller, Klaus-Thomas Kronmueller, Michael N. Smolka, Peter Schlattmann, Maximilian Berger, Roland Ricken, Thomas J. Stamm, Andreas Heinz, Michael Bauer
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Endocrinology & Metabolism
Vladimir M. Milenkovic, Nina Sarubin, Sven Hilbert, Thomas C. Baghai, Friederike Stoffler, Juan M. Lima-Ojeda, Andre Manook, Khalifa Almeqbaali, Christian H. Wetzel, Rainer Rupprecht, Caroline Nothdurfter
NEUROIMMUNOMODULATION
(2017)
Review
Psychiatry
Juan M. Lima-Ojeda, Rainer Rupprecht, Thomas C. Baghai
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2018)
Review
Psychiatry
Juan M. Lima-Ojeda, Rainer Rupprecht, Thomas C. Baghai
FRONTIERS IN PSYCHIATRY
(2017)
Article
Biochemistry & Molecular Biology
Thomas C. Baghai, Gabriella Varallo-Bedarida, Christoph Born, Sibylle Haefner, Cornelius Schuele, Daniela Eser, Peter Zill, Andre Manook, Johannes Weigl, Somayeh Jooyandeh, Caroline Nothdurfter, Clemens von Schacky, Brigitta Bondy, Rainer Rupprecht
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Clinical Neurology
Roland Ricken, Katja Wiethoff, Thomas Reinhold, Thomas J. Stamm, Thomas C. Baghai, Robert Fisher, Florian Seemueller, Peter Brieger, Joachim Cordes, Gerd Laux, Iris Hauth, Hans-Juergen Moeller, Andreas Heinz, Michael Bauer, Mazda Adli
JOURNAL OF AFFECTIVE DISORDERS
(2018)
Article
Psychiatry
Anna K. Schmidtner, David A. Slattery, Joachim Glaesner, Andreas Hiergeist, Katharina Gryksa, Victoria A. Malik, Julian Hellmann-Regen, Isabella Heuser, Thomas C. Baghai, Andre Gessner, Rainer Rupprecht, Barbara Di Benedetto, Inga D. Neumann
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Neurosciences
Caroline Nothdurfter, Vladimir M. Milenkovic, Nina Sarubin, Sven Hilbert, Andre Manook, Johannes Weigl, Khalifa Almeqbaali, Christian H. Wetzel, Rainer Rupprecht, Thomas C. Baghai
Summary: During antidepressive treatment, elevated levels of IL-17A may indicate therapy resistance, highlighting its critical role in inflammatory responses.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Kerstin Kuffner, Julian Triebelhorn, Katrin Meindl, Christoph Benner, Andre Manook, Daniel Sudria-Lopez, Ramona Siebert, Caroline Nothdurfter, Thomas C. Baghai, Konstantin Drexler, Mark Berneburg, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel
Article
Psychiatry
Peter M. Kreuzer, Thomas C. Baghai, Rainer Rupprecht, Markus Wittmann, Dagmar Steffling, Michael Ziereis, Marc Zowe, Helmut Hausner, Berthold Langguth
FRONTIERS IN PSYCHIATRY
(2020)
Article
Clinical Neurology
J. M. Lima-Ojeda, R. Rupprecht, T. C. Baghai
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)