Journal
BIOMEDICAL OPTICS EXPRESS
Volume 6, Issue 5, Pages 1812-1827Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.001812
Keywords
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Funding
- National Institutes of Health [R00EB007241, K08NS059674, R01NS081243]
- US National Science Foundation [IGERT: DGE 0903667]
- UC Discovery Grant Program [213073]
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Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation. (C) 2015 Optical Society of America.
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