Article
Endocrinology & Metabolism
Ann-Elin Meling Stokland, Grethe Ueland, Kari Lima, Kaja Gronning, Trine E. Finnes, Margrethe Svendsen, Aneta Ewa Tomkowicz, Synnove Emblem Holte, Stina Therese Sollid, Aleksandra Debowska, Hallvard Singsas, Marthe Landsverk Rensvik, Helle Lejon, Dag-Erik Sormo, Anders Svare, Sigrid Blika, Petya Milova, Elin Korsgaard, Oystein Husby, Lars Breivik, Anders P. Jorgensen, Eystein Sverre Husebye
Summary: Autoimmune thyroid disease is a common comorbidity in autoimmune Addison disease (AAD). This study found that 48% of AAD patients had autoimmune thyroid disease, with 42% having autoimmune hypothyroidism. Among the patients diagnosed with autoimmune hypothyroidism, 20% had overt hypothyroidism, 73% had subclinical hypothyroidism, and 7% had normal thyroid function. A significant percentage of patients had negative thyroid peroxidase antibodies. The majority of patients were treated with levothyroxine, while a small percentage received combination therapy or no treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Qing Zhou, Shuai Xue, Li Zhang, Guang Chen
Summary: Trace elements are crucial for thyroid function and metabolism, and their imbalance can lead to thyroid disorders. The relationship between trace elements and thyroid diseases is still unclear and requires further research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Beata Pyrzak, Malgorzata Ruminska, Ewelina Witkowska-Sedek, Anna Kucharska
Summary: Maternal Graves' disease can cause various thyroid dysfunctions in newborns, including hyperthyroidism and hypothyroidism. This study found that transient hyperthyroidism was the most common thyroid dysfunction in newborns with neonatal hyperthyroidism, but central hypothyroidism can also occur.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Vicente A. Benites-Zapata, Felipe L. Ignacio-Cconchoy, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Percy Herrera-Anazco
Summary: This study reviewed existing studies to assess differences in serum vitamin B12 levels among patients with and without thyroid disorders (TD), frequency of vitamin B12 deficiency, and presence of anti-parietal cell antibodies in TD patients. Results showed that patients with hypothyroidism had lower vitamin B12 levels compared to healthy participants, while no significant differences were observed in patients with hyperthyroidism, autoimmune thyroid disease (AITD), or subclinical hypothyroidism (SH). The frequencies of vitamin B12 deficiency were 27%, 6%, 27%, and 18% for hypothyroidism, hyperthyroidism, SH, and AITD respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Martin Andersson, Soren Mattsson
Summary: Radioactive iodine is commonly used for the treatment of thyroid diseases, with EANM and ICRP developing pre-therapeutic procedures and biokinetic models. Combining the EANM method and ICRP model provides more accurate patient-specific dosimetry estimates and absorbed dose estimates including most organs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jakob Skov, Jan Calissendorff, Daniel Eriksson, Patrik Magnusson, Olle Kampe, Sophie Bensing, Ralf Kuja-Halkola
Summary: Hashimoto's thyroiditis (HT) and Graves' disease (GD) have a modest genetic relationship, with genetic factors playing a more significant role in men's susceptibility to HT compared to women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Larisse Vieira Mendes Araruna, Daniela Camargo de Oliveira, Monica Corso Pereira, Arnaldo Moura Neto, Marcos Antonio Tambascia, Denise Engelbrecht Zantut-Wittmann
Summary: This study highlights the importance of cardiorespiratory reassessment in patients with Graves' disease even after long-term control of hyperthyroidism. Results indicate that about 30% of these patients still have pulmonary hypertension, which requires specific treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Carlos King Ho Wong, David Tak Wai Lui, Xi Xiong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Ivan Chi Ho Au, Matthew Shing Hin Chung, Franco Wing Tak Cheng, Kathryn Choon Beng Tan, Ian Chi Kei Wong
Summary: The study found no evidence of an increased risk of incident hyperthyroidism or hypothyroidism following vaccination with BNT162b2 and CoronaVac COVID-19 vaccines.
Article
Endocrinology & Metabolism
Jakob Skov, Ralf Kuja-Halkola, Patrik K. E. Magnusson, Soffia Gudbjornsdottir, Olle Kampe, Sophie Bensing
Summary: Type 1 diabetes and Hashimoto's thyroiditis often coexist in individuals and families, with shared genetic and environmental factors contributing to their etiology. Twins have a higher risk of developing both diseases compared to the general population. Genetic factors account for a portion of the overlap, while unique environmental factors also play a significant role.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Shuai Song, Congcong Jia, ChunJing Li, Yuxia Ma
Summary: Observational studies have found associations between thyroid disease and gout, but this study used Mendelian randomization analysis to investigate the causal relationship. The results showed that autoimmune hypothyroidism and autoimmune hyperthyroidism increased the risk of gout, while thyroid nodules and thyroid cancer did not have a causal effect on gout.
Article
Medicine, General & Internal
Hyo Geun Choi, Young Shin Song, Jee Hye Wee, Chanyang Min, Dae Myoung Yoo, So Young Kim
Summary: The study found an association between BPPV and thyroid disorders such as goiter, hypothyroidism, thyroiditis, and hyperthyroidism, with the prevalence of these diseases being higher in the BPPV group compared to the control group.
Article
Endocrinology & Metabolism
Juliane Leger, Clemence Delcour, Jean-Claude Carel
Summary: This article discusses the diagnosis and management of fetal and neonatal thyroid dysfunctions, including congenital hypothyroidism, autoimmune hyperthyroidism, and other rare disorders. Early diagnosis and treatment are crucial in preventing irreversible neurodevelopmental delay.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Ibtissem Oueslati, Salma Salhi, Meriem Yazidi, Fatma Chaker, Melika Chihaoui
Summary: Graves' disease and Hashimoto's thyroiditis are two autoimmune thyroid diseases, and the occurrence of Hashimoto's thyroiditis following Graves' disease has been rarely reported. The case report describes a patient who developed Hashimoto's thyroiditis several years after receiving treatment for Graves' disease.
CLINICAL CASE REPORTS
(2022)
Review
Medicine, General & Internal
Federica Gagliardi, Enke Baldini, Eleonora Lori, Silvia Cardarelli, Daniele Pironi, Augusto Lauro, Domenico Tripodi, Piergaspare Palumbo, Eleonora D'Armiento, Giuseppe Cavallaro, Andrea Polistena, Valerio D'Orazi, Simone Sibio, Poupak Fallahi, Alessandro Antonelli, Vito D'Andrea, Salvatore Ulisse, Salvatore Sorrenti
Summary: Benign and malignant thyroid diseases are linked to the occurrence of extrathyroidal malignancies, including colorectal cancers. Understanding the relationship between these diseases can provide insights into their etiology and/or progression, as well as potential shared genetic and environmental factors. Exploring the underlying molecular mechanisms can lead to improved clinical management and increased surveillance for patients with thyroid diseases at a higher risk of developing extrathyroidal malignancies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Gloria Tena Vivo, Neus Parellada Esquius, Oriol Cunillera Puertolas, Merce Albareda Riera, Monica Isidro Albaladejo, Lluis Vila Ballester
Summary: This study examined the prevalence of known thyroid disorders and hypothyroidism before pregnancy in Catalonia, Spain between 2014 and 2016. The findings showed that a significant number of women with thyroid disorders were not properly monitored during the year before pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Paschalia K. Iliadou, Grigoris Effraimidis, Michalakis Konstantinos, Panagiotou Grigorios, Periklis Mitsakis, Frideriki Patakiouta, Kalliopi Pazaitou-Panayiotou
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2015)
Correction
Endocrinology & Metabolism
Paschalia K. Iliadou, Grigoris Effraimidis, Michalakis Konstantinos, Panagiotou Grigorios, Periklis Mitsakis, Frideriki Patakiouta, Kalliopi Pazaitou-Panayiotou
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2016)
Article
Multidisciplinary Sciences
Elske T. Massolt, Grigoris Effraimidis, Tim I. M. Korevaar, Wilmar M. Wiersinga, W. Edward Visser, Robin P. Peeters, Hemmo A. Drexhage
Article
Endocrinology & Metabolism
Stavroula A. Paschou, Eleni Palioura, Fotios Kothonas, Alexandros Myroforidis, Vasiliki Loi, Androniki Poulou, Konstantinos Goumas, Grigoris Effraimidis, Andromachi Vryonidou
Article
Endocrinology & Metabolism
Wouter Beumer, Grigoris Effraimidis, Roosmarijn C. Drexhage, Wilmar M. Wiersinga, Hemmo A. Drexhage
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Review
Endocrinology & Metabolism
Grigoris Effraimidis
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2019)
Review
Clinical Neurology
Kalliopi Alpantaki, Alkisti Kampouroglou, Christos Koutserimpas, Grigoris Effraimidis, Alexander Hadjipavlou
EUROPEAN SPINE JOURNAL
(2019)
Review
Endocrinology & Metabolism
Grigoris Effraimidis, Ase K. Rasmussen, Henning Bundgaard, Soren S. Sorensen, Ulla Feldt-Rasmussen
JOURNAL OF INHERITED METABOLIC DISEASE
(2020)
Article
Genetics & Heredity
Grigoris Effraimidis, Ulla Feldt-Rasmussen, Ase Krogh Rasmussen, Pamela Lavoie, Mona Abaoui, Michel Boutin, Christiane Auray-Blais
Summary: Recent studies have shown the utility of lyso-Gb(3) and related analogues as biomarkers for Fabry disease patients. This study found a strong correlation between plasma and urine levels of lyso-Gb(3) and analogues, with significant reductions post-treatment in treated patients compared to untreated patients. These findings suggest that biomarker cut-off levels could potentially be a useful tool for treatment initiation in Fabry disease patients.
JOURNAL OF MEDICAL GENETICS
(2021)
Review
Endocrinology & Metabolism
Grigoris Effraimidis, Torquil Watt, Ulla Feldt-Rasmussen
Summary: Treatment with Levothyroxine (L-T4) for overt hypothyroidism in elderly patients is more challenging compared to younger patients due to higher prevalence of comorbidities and cardiovascular complications. Collaboration between endocrinologists and cardiologists is crucial for successful treatment, especially in cases of cardiac ischemia. Correct diagnosis and management are essential, and more studies are needed to determine the benefits and risks of treating mild hypothyroidism in the elderly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Ulla Feldt-Rasmussen, Grigoris Effraimidis, Marianne Klose
Summary: The hypothalamus-pituitary-thyroid axis is an important hormone regulatory system that plays a crucial role in physiology and pathophysiology. The complexity of diagnosing central hypothyroidism is further complicated by the influence of other hormone axes, and treatment can also impact the function of other axes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Oncology
Grigoris Effraimidis, Ulrich Knigge, Maria Rossing, Peter Oturai, Ase Krogh Rasmussen, Ulla Feldt-Rasmussen
Summary: Neuroendocrine neoplasms (NENs) are rare tumors that have shown a significant increase in incidence over the past four decades. These tumors arise from neuroendocrine cells and have diverse presentations and behaviors, depending on the organ involved. Multiple endocrine neoplasia type 1 (MEN-1) is a key genetic syndrome associated with NENs and research on diagnosis and treatment is progressing.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Jes Sloth Mathiesen, Grigoris Effraimidis, Maria Rossing, Ase Krogh Rasmussen, Lise Hoejberg, Lars Bastholt, Christian Godballe, Peter Oturai, Ulla Feldt-Rasmussen
Summary: Multiple endocrine neoplasias are rare hereditary syndromes with some having malignant potential. This review summarizes recent developments in the understanding of these syndromes and their impact on clinical management, including improved risk classification and genetic counseling. Future research directions are also highlighted to improve survival and morbidity in these patients.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Genetics & Heredity
Puriya Daniel Wurtz Yazdanfard, Grigoris Effraimidis, Christoffer Vladorff Madsen, Lars Holme Nielsen, Ase Krogh Rasmussen, Jorgen Holm Petersen, Soren Schwartz Sorensen, Lars Kober, Vitor Hugo Fraga de Abreu, Vibeke Andree Larsen, Ulla Feldt Rasmussen
Summary: This study investigated hearing loss in Fabry disease (FD) patients and compared their audiometric data to other clinical variables. The results showed significant hearing loss in FD patients at all frequencies and no improvement in hearing with treatment. Male patients had more profound hearing loss than female patients at high frequencies (4,8 kHz). Lower plasma Gb3 concentrations correlated with better hearing in males.
MOLECULAR GENETICS AND METABOLISM REPORTS
(2022)
Article
Multidisciplinary Sciences
Grigoris Effraimidis, Ase Krogh Rasmussen, Morten Dunoe, Lis F. Hasholt, Flemming Wibrand, Soren S. Sorensen, Allan M. Lund, Lars Kober, Henning Bundgaard, Puriya D. W. Yazdanfard, Peter Oturai, Vibeke A. Larsen, Vitor Hugo Fraga de Abreu, Lotte Hahn Enevoldsen, Tatiana Kristensen, Kirsten Svenstrup, Margrethe Bastholm Bille, Farah Arif, Mette Mogensen, Mads Klokker, Vibeke Backer, Caroline Kistorp, Ulla Feldt-Rasmussen
Summary: The present study provides molecular and biochemical data of the Danish Fabry cohort and reports the experience of cascade genetic screening at the Danish National Fabry Disease Center over a period of 20 years. The study findings demonstrate the identification of pathogenic GLA variants in 96 family members through cascade genetic testing and the discovery of six previously unreported disease-causing variants in the GLA gene.
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)