Article
Endocrinology & Metabolism
Yanyun Zhao, Yue Zhou, Jingwei Chi, Kui Che, Yangang Wang, Wei Wang
Summary: This study aimed to compare the levels of serum pancreatic polypeptide (PP), insulin (INS), C-peptide (C-P), and glucagon (GCG) before and after glucose stimulation in type 2 diabetes mellitus (T2DM) patients with different body mass indexes (BMI). The results showed that overweight and obese subjects had impaired PP secretion after glucose stimulation compared to normal-weight subjects. Multiple linear regression analysis revealed that PP secretion was mainly affected by BMI and GCG. These findings contribute to understanding the role of PP in the development of obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Deepali Gupta, Georgina K. C. Dowsett, Bharath K. Mani, Kripa Shankar, Sherri Osborne-Lawrence, Nathan P. Metzger, Brian Y. H. Lam, Giles S. H. Yeo, Jeffrey M. Zigman
Summary: Islets are important sites for the action of the hormone ghrelin, with expression of the ghrelin receptor (GHSR) found in alpha, beta, and somatostatin-secreting delta cells. Further analysis revealed that PP-expressing gamma cells in mice and humans are also likely direct targets for ghrelin and its antagonist LEAP2.
Article
Physiology
Leah R. Caplan, Vera Vavinskaya, David G. Gelikman, Nidhi Jyotsana, Vincent Q. Trinh, Kenneth P. Olive, Marcus C. B. Tan, Kathleen E. DelGiorno
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a low survival rate. Acinar-to-ductal metaplasia (ADM) is found to be associated with hormone-producing enteroendocrine cells (EECs). Through studies on mouse models and human disease, it is discovered that EECs are most abundant in ADM and decrease significantly with lesion progression.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yanyun Zhao, Yue Zhou, Min Xiao, Yajing Huang, Mengmeng Qi, Zili Kong, Jingwei Chi, Kui Che, Wenshan Lv, Bingzi Dong, Yangang Wang
Summary: This study compared serum levels of pancreatic polypeptide (PP), insulin, C-peptide, and glucagon in different glucose tolerance stages. The results showed that IGR and T2DM patients have enhanced postprandial PP secretion, mainly affected by BMI and blood glucose levels.
JOURNAL OF DIABETES
(2022)
Article
Cell Biology
Christoffer A. Hagemann, Malene S. Jensen, Stephanie Holm, Laerke S. Gasbjerg, Sarah Byberg, Kirsa Skov-Jeppesen, Bolette Hartmann, Jens J. Holst, Flemming Dela, Tina Vilsboll, Mikkel B. Christensen, Birgitte Holst, Filip K. Knop
Summary: This study investigates the effects of exogenous LEAP2 on postprandial glucose metabolism and ad libitum food intake. The results show that LEAP2 infusion lowers postprandial plasma glucose and growth hormone concentrations and decreases food intake.
CELL REPORTS MEDICINE
(2022)
Article
Chemistry, Applied
Keying Yang, Ying Yang, Yun Xie, Yingyi Mao, Xiang Li, Qing Guo
Summary: Achieving proper postprandial glycemic control is crucial for preventing and managing diabetes, but limited data is available on the precise effect of macronutrients due to food structure. This study formulated 7 nutrition shakes with balanced macronutrients and similar structures but different protein, oil, carbohydrate, and fiber sources. The results showed that soybean protein and medium-chain triglycerides (MCT) decreased blood glucose levels compared to sodium caseinate and long-chain triglycerides (LCT) respectively. Maltodextrin decreased peak blood glucose levels and maltodextrin + whey protein and MCT + whey protein + syrup + fructo-oligosaccharide (FOS) showed reduced food intake.
FOOD HYDROCOLLOIDS
(2023)
Article
Nutrition & Dietetics
Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada
Summary: d-allulose can suppress hunger-associated feeding and inhibit hunger-promoting neurons in the hypothalamic arcuate nucleus.
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Behavioral Sciences
Carin Weirich Gallon, Charles Francisco Ferreira, Aline Henz, Carolina Leao Oderich, Maiara Conzatti, Juliana Ritondale Sodre de Castro, Matheus Parmegiani Jahn, Keoma da Silva, Maria Celeste Osorio Wender
Summary: The study found that participants with PMS consumed more calories and carbohydrates during the luteal phase compared to the follicular phase, while this pattern was not observed in participants without PMS. There was a marginal negative relationship between ghrelin levels and calorie intake in the follicular phase of the PMS group, and a negative relationship between ghrelin and leptin levels in the luteal phase of the group without PMS.
Article
Nutrition & Dietetics
Natalya J. Beer, Ben Jackson, James A. Dimmock, Kym J. Guelfi
Summary: This study aimed to investigate the effects of 12 weeks of sprint interval training (SIT) combined with need-support on post-exercise food consumption. The results showed that SIT with psychological need-support significantly decreased post-exercise energy intake from snacks, while traditional moderate-intensity continuous training (MICT) did not affect food intake. SIT with need-support is well-tolerated in physically inactive individuals with overweight and offers an alternative to traditional exercise prescription.
Review
Endocrinology & Metabolism
Ruben Nogueiras
Summary: Obesity is a global epidemic that poses significant health and economic challenges worldwide. Recent research has highlighted the role of gut hormones in regulating energy balance, feeding behavior, energy expenditure, and weight loss. Some of these hormones can act on the hypothalamus independently of food intake to modulate thermogenesis and adiposity.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J. Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Summary: The study reveals that acetylcholine signals are transmitted through a rapid co-activation mechanism, activating receptors on multiple neurons surrounding the release site. Additionally, while acetylcholine signals are direction-selective locally, they do not show global directionality, facilitating information transfer at a local scale.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Wenjie Zhang, Yuan Chen, Hui Pei
Summary: C1q is an essential component of the complement system, performing non-specific immune functions and playing a crucial role in immune homeostasis and normal physiological functions. In the developing central nervous system, C1q is involved in synapse formation, pruning, and the development of neuronal networks. C1q has a close relationship with microglia and astrocytes and may contribute to the development of CNS disorders. Clinical trials are already underway for CNS disorders, highlighting the potential therapeutic target of C1q.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebekka Thogersen, Ida Emilie I. Lindahl, Bekzod Khakimov, Louise Kjolbaek, Klaus Juhl Jensen, Arne Astrup, Marianne Hammershoj, Anne Raben, Hanne Christine Bertram
Summary: The study examined the postprandial plasma phospholipid levels following consumption of different dairy products and found a lower plasma level of specific lyso-phosphatidylethanolamines (LPEs) and lyso-phosphatidylcholines (LPCs) following consumption of the gel made from micellar casein isolate (MCI) compared to MCI drink and homogenized cheese. However, further studies are needed to reveal more details on the effect of the dairy matrix on postprandial phospholipids.
Review
Biochemistry & Molecular Biology
Bowen Jia, Jing Li, Yiting Song, Chengliang Luo
Summary: Ferroptosis is a form of iron-dependent regulated cell death characterized by iron-dependent lipid peroxidation and has been implicated in various diseases, including nervous system diseases and injuries. ACSL4, a member of the ACSLs family, is involved in the regulation of arachidonic acid and eicosapentaenoic acid, leading to ferroptosis. Understanding the molecular mechanisms of ACSL4-mediated ferroptosis will contribute to the development of new treatment strategies for these diseases or injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Gordon B. Feld, Jan Born
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Marjan Alizadeh Asfestani, Valentin Brechtmann, Joao Santiago, Andreas Peter, Jan Born, Gordon Benedikt Feld
JOURNAL OF COGNITIVE NEUROSCIENCE
(2020)
Editorial Material
Neurosciences
Niels Niethard, Jan Born
Article
Multidisciplinary Sciences
Luciana Besedovsky, Mona Benischke, Joerg Fischer, Amir S. Yazdi, Jan Born
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Manuela Friedrich, Matthias Moelle, Angela D. Friederici, Jan Born
NATURE COMMUNICATIONS
(2020)
Article
Clinical Neurology
Jules Schneider, Penelope A. Lewis, Dominik Koester, Jan Born, Hong-Viet V. Ngo
Article
Neurosciences
Carlos N. Oyanedel, Ernesto Duran, Niels Niethard, Marion Inostroza, Jan Born
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Behavioral Sciences
Anuck Sawangjit, Carlos N. Oyanedel, Niels Niethard, Jan Born, Marion Inostroza
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Biology
Cecilia Forcato, Jens G. Klinzing, Julia Carbone, Michael Radloff, Frederik D. Weber, Jan Born, Susanne Diekelmann
COMMUNICATIONS BIOLOGY
(2020)
Article
Neurosciences
Niels Niethard, Svenja Brodt, Jan Born
Summary: The study revealed that during slow-wave sleep, excitatory pyramidal cells showed decreased calcium activity, but the variance in activity increased, indicating a heterogeneous regulation of network activity. Some pyramidal cells exhibited increased calcium activity during slow-wave sleep, potentially involved in memory processing.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Kathrin Thiede, Jan Born, Albrecht P. A. Vorster
Summary: Sleep is crucial for memory consolidation after learning, but may not be necessary for simple reflex conditioning. Extinction training did not reverse the enhanced response to the conditioned stimulus, and responses were further increased at the 48-hour test, suggesting a contribution of sensitization processes to the withdrawal response.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Luciana Besedovsky, Maren Cordi, Laura Wisslicen, Estefania Martinez-Albert, Jan Born, Bjoern Rasch
Summary: The use of hypnotic suggestions to enhance slow wave sleep (SWS) has been found to significantly affect the endocrine and autonomic nervous systems. Hypnotic suggestions can increase the release of growth hormone and shift the sympathovagal balance, leading to a whole-body pattern characteristic of natural SWS.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Manuela Friedrich, Matthias Moelle, Jan Born, Angela D. Friederici
Summary: This study investigated the memory of nonadjacent dependencies in 6-8 month old infants and examined whether sleep after learning affects this memory. The results showed that infants were able to retain memory of nonadjacent dependencies regardless of whether they napped or stayed awake. However, napping did affect a specific processing stage, suggesting that memory evolves during sleep.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Maria P. Contreras, Julia Fechner, Jan Born, Marion Inostroza
Summary: Research shows that discrete spatial experience can accelerate the maturation of spatial memory systems in the brain. This maturation is driven by specific sleep oscillations, which contribute to the formation of long-term memory and knowledge. The findings suggest that experience plays a positive role in the development of memory systems.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Janna D. Lendner, Niels Niethard, Bryce A. Mander, Frank J. van Schalkwijk, Sigrid Schuh-Hofer, Hannah Schmidt, Robert T. Knight, Jan Born, Matthew P. Walker, Jack J. Lin, Randolph F. Helfrich
Summary: The study shows that non-oscillatory brain activity during REM sleep plays a key role in the sleep-dependent recalibration of neural population dynamics. The extent of REM sleep recalibration predicts the success of overnight memory consolidation by favoring remembering over forgetting. This non-oscillatory mechanism explains how REM sleep enhances long-term memory in humans.
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)