☆ 4.5 Article

Decreased prevalence of left-handedness among females with male co-twins: Evidence suggesting prenatal testosterone transfer in humans?

PSYCHONEUROENDOCRINOLOGY (2010)

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Journal

PSYCHONEUROENDOCRINOLOGY
Volume 35, Issue 10, Pages 1462-1472

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2010.04.013

Keywords

Laterality; Masculinisation; Prenatal testosterone transfer; Sex difference; Testosterone

Categories

Endocrinology & Metabolism Neurosciences Psychiatry

Funding

  1. National Institute of Alcohol Abuse and Alcoholism [AA-12502, AA-00145, AA-09203]
  2. Academy of Finland [100499, 205585, 118555]
  3. Academy of Finland Centre of Excellence in Complex Disease Genetics
  4. Finnish Cultural Foundation (Helvi and Arvo Lehtovaara Foundation)

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Studies of singletons suggest that right-handed individuals may have higher levels of testosterone than do left-handed individuals. Prenatal testosterone levels are hypothesised to be especially related to handedness formation. In humans, female members from opposite-sex twin pairs may experience elevated level of prenatal exposure to testosterone in their intrauterine environment shared with a male. We tested for differences in rates of left-handedness/right-handedness in female twins from same-sex and opposite-sex twin pairs. Our sample consisted of 4736 subjects, about 70% of all Finnish twins born in 1983-1987, with information on measured pregnancy and birth related factors. Circulating testosterone and estradiol levels at age 14 were available on 771 and 744 of these twins, respectively. We found significantly (p = .006) lower prevalence of left-handedness in females from opposite-sex pairs (5.3%) compared to females from same-sex pairs (8.6%). The circulating levels of neither testosterone nor estradiol related to handedness in either females or males. Nor were there differences in circulating testosterone or estradiol levels between females from opposite-sex and same-sex twin pairs. Birth and pregnancy related factors for which we had information were unrelated to handedness. Our results are difficult to fully explain by postnatal factors, but they offer support to theory that relates testosterone to formation of handedness, and in a population-based sample, are suggestive of effects of prenatal testosterone transfer. (C) 2010 Elsevier Ltd. All rights reserved.

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Article Endocrinology & Metabolism

Effects of menstrual cycle phase and ovulation on the salivary cortisol awakening response

Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes

Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.

PSYCHONEUROENDOCRINOLOGY (2024)

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Article Endocrinology & Metabolism

Sex-specific prefrontal-hypothalamic control of behavior and stress responding

Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers

Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.

PSYCHONEUROENDOCRINOLOGY (2024)

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Article Endocrinology & Metabolism

Relationship between COVID-related stressors and internalizing symptoms: Gendered neuroendocrine risk profiles

Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran

Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.

PSYCHONEUROENDOCRINOLOGY (2024)

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Article Endocrinology & Metabolism

Adrenocortical and autonomic cross-system regulation in youth: A meta-analysis

Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry

Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.

PSYCHONEUROENDOCRINOLOGY (2024)

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Article Endocrinology & Metabolism

Heterogeneity and synaptic plasticity analysis of hippocampus based on db-/- mice induced diabetic encephalopathy

Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li

Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.

PSYCHONEUROENDOCRINOLOGY (2024)

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Article Endocrinology & Metabolism

A 4-session written emotional disclosure intervention lowers 6-month sympathoadrenal urinary output in persons living with HIV

Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson

Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.

PSYCHONEUROENDOCRINOLOGY (2024)

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Article Endocrinology & Metabolism

Threat exposure moderates associations between neural and physiological indices of emotion reactivity in adolescent females

Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan

Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.

PSYCHONEUROENDOCRINOLOGY (2024)

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