Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: A study found an inverse linear relationship between fetal growth and HPA-A function at the age of 18, which may be related to altered adrenal sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: The study found an inverse linear relationship between fetal growth and HPA-A function at age 18, with no consistent quadratic relationships identified. Removal of anticipatory responders from the models substantially attenuated the observed relationships. This suggests altered adrenal sensitivity may underlie the relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Aleksandra S. S. Stojiljkovic, Zeljko Cupic, Stevan Macesic, Ana Ivanovic-Sasic, Ljiljana Kolar-Anic
Summary: This study investigates the mechanisms underlying the effects of arginine vasopressin (AVP) on the Hypothalamic-Pituitary-Adrenal (HPA) axis and reveals the influence of the synergistic action between AVP and corticotrophin-releasing hormone (CRH) on the ultradian dynamics of the HPA axis. The extended nonlinear network reaction model incorporates AVP into the HPA axis model and explores the conditions under which the HPA system transitions between oscillatory and stable states. The results demonstrate the importance of the synergy reaction rate constant and highlight the superior stimulatory effect of CRH compared to AVP on ACTH secretion in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Lekshmi Sambhu Hema, Prawin Kumar, Jagdish Prasad Goyal, Varuna Vyas, Kuldeep Singh
Summary: This study aims to assess the effect of long-term use of inhaled corticosteroids (ICS) on the hypothalamic-pituitary-adrenal (HPA) axis. By measuring cortisol levels and conducting adreno-corticotropic hormone (ACTH) stimulation tests, it was found that only a few asthmatic children using ICS showed HPA axis suppression, and there was no clinical evidence supporting this suppression.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Christina Tatsi, Megan Neely, Chelsi Flippo, Maria-Eleni Bompou, Meg Keil, Constantine A. Stratakis
Summary: The recovery of adrenal function in pediatric patients with CD after TSS may not be influenced by most clinical and biochemical factors, except for an increase in urinary free cortisol which may prolong the recovery time. Patients who recover adrenal function earlier are at a higher risk for CD recurrence, highlighting the importance of close follow-up and counseling for these patients.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hongyuan Zhu, Luming Wu, Tingwei Su, Lei Jiang, Weiwei Zhou, Yiran Jiang, Cui Zhang, Xu Zhong, Weiqing Wang
Summary: This study investigated the association between radiological characteristics of benign adrenocortical tumors and the hypothalamus-pituitary-adrenal (HPA) axis in 494 patients. It was found that patients with mild autonomous cortisol secretion (MACS) had larger tumor diameter, thinner contralateral adrenal gland, and lower plasma ACTH and serum DHEAS levels compared to those with non-functional adrenocortical tumors (NFAT). ACTH was shown to mediate the effects of MACS on DHEAS and contralateral adrenal gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jacinda C. Li, Molly A. Hall, Idan Shalev, Hannah M. C. Schreier, Tomas Gonzalez Zarzar, Isabel Marcovici, Frank W. Putnam, Jennie G. Noll
Summary: This study suggests a mechanistic association between HPA axis attenuation and obesity, with the attenuated cortisol growth rate mediating the effects of childhood sexual abuse on accelerated BMI accumulation and elevated adulthood obesity rates.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Biology
Isabella Robertson-Dixon, Melanie J. Murphy, Sheila G. Crewther, Nina Riddell
Summary: This systematic review evaluated the effects of daytime exposure to lights of different spectral wavelength characteristics and luminance intensity on cortisol levels in healthy individuals. The analysis indicated that exposure to bright lights of any color during the late night or early morning can significantly increase cortisol secretion, and exposure to bright lights with stronger short-wavelength (blue/green) components in the early morning typically induces greater increases in cortisol. Therefore, the circadian regulation of cortisol is sensitive to the wavelength composition of environmental lighting.
Article
Psychology, Multidisciplinary
Qian Liu, Jianhui Wu, Liang Zhang, Xiaofang Sun, Qing Guan, Zhuxi Yao
Summary: This study found that, for the same level of stress, the subjective perceived level of control in young adults can influence the activation of the hypothalamic-pituitary-adrenal axis.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Immunology
Juan P. Sanabria-Mazo, Ariadna Colomer-Carbonell, Meritxell Carmona-Cervello, Albert Feliu-Soler, Xavier Borras, Mar Grasa, Montserrat Esteve, Michael Maes, Silvia Edo, Antoni Sanz, Juan V. Luciano
Summary: This systematic review identified preliminary evidence of increased levels of certain immune-inflammatory and HPA axis biomarkers in individuals with NSLBP, but also noted inconsistent results for some biomarkers. Additionally, insufficient evidence was found for IL-6, TNF-alpha, and CRP levels in NSLBP when compared exclusively with healthy controls. The dysregulated functioning of cortisol in NSLBP patients further adds complexity to the understanding of the immune-inflammatory and HPA axis biomarkers in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Dawn L. Ramdas, Marissa D. Sbrilli, Heidemarie K. Laurent
Summary: This study investigated the relationship between trauma-related psychopathology, life stress, and HPA axis response in mothers parenting their infants. The findings showed that trauma-related psychopathology did not have a significant impact on maternal cortisol response, but PTSD diagnosis and ongoing trauma symptoms reduced the effects of life events on cortisol reactivity. Mothers without trauma-related psychopathology showed more pronounced cortisol reactivity in response to life stress compared to those with trauma-related psychopathology.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Hrafnhildur Gunnarsdottir, Gunnel Hensing, Anne Hammarstrom
Summary: This longitudinal study found that poor school connectedness in adolescence can impact depressiveness in adulthood, while family climate was not associated with depressiveness. The study suggests the need for more life-course studies to advance understanding of the mechanisms behind the associations between family climate, school connectedness, and depressiveness in adulthood.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Per E. Gustafsson, Miguel San Sebastian, Osvaldo Fonseca-Rodriguez, Anne-Marie Fors Connolly
Summary: This study examines social gradients in COVID-19 outcomes in Sweden, finding significant disparities in hospitalizations, intensive care admissions, and deaths by education, income, and country of birth. These inequities appear to be unrelated to pre-existing health disparities, suggesting that management of confirmed COVID-19 cases could play a role in mitigating these outcomes.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Nadja Fagrell Trygg, Anna Mansdotter, Per E. Gustafsson
Summary: Intersectionality has become prominent in health inequality research, focusing on multiple intersecting dimensions of inequality. This study examined mental health inequalities across various dimensions and found that income played a significant role, with the sum of dimensions contributing to overall inequality. The study highlights the importance of empirical investigations into unpredictable inequality patterns revealed by an intersectional approach.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Osvaldo Fonseca-Rodriguez, Per E. Gustafsson, Miguel San Sebastian, Anne-Marie Fors Connolly
Summary: This study identified high-risk spatial clusters for hospitalisations and deaths due to COVID-19 in Sweden from February 2020 to October 2020. The hospitalisations and deaths were associated with population density, the proportion of immigrants and the proportion of people aged 65+ years.
Article
Medicine, General & Internal
Per E. Gustafsson, Ingeborg Nilsson, Miguel San Sebastian
Summary: This study examines the early impact of the pandemic and quarantine measures on loneliness among older adults in Sweden. The results show a 14% increase in loneliness in Spring 2020 compared to 2019, but no significant impact of the quarantine measures. This suggests that older adults receiving home care in Sweden have relative resilience to quarantine measures during the initial months of the pandemic.
Article
Public, Environmental & Occupational Health
Nadja Fagrell Trygg, Per E. Gustafsson, Anna-Karin Hurtig, Anna Mansdotter
Summary: This study aims to critically analyze the representation of health inequalities in a government bill and explore its performative power and alternative representations.
Article
Immunology
Alieu Sowe, Fredinah Namatovu, Bai Cham, Per E. Gustafsson
Summary: This study assessed the impact of a results-based financing (RBF) project on national vaccination coverage, coverage in intervention and non-intervention areas, and rural-urban coverage inequality in The Gambia. The results showed an overall improvement in vaccination coverage, and the RBF project contributed to reducing rural-urban inequality.
Article
Geriatrics & Gerontology
Per E. Gustafsson, Julia Schroders, Ingeborg Nilsson, Miguel San Sebastian
Summary: This study aimed to examine the impact on loneliness of the early phase of the pandemic and of a national visiting ban at nursing homes for Swedish nursing home residents. The results showed a moderate increase in loneliness, which could be explained by self-reported health. The nationwide visiting ban did not have an additional impact on loneliness trends.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cynthia Anticona, Pernilla Lif Holgerson, Per E. Gustafsson
Summary: The goal of the Swedish oral healthcare system is to achieve good oral health and equitable access to care for the entire population. This study examines complex inequities in unmet oral care needs among adults in Sweden from 2004 to 2021 using an intersectional approach.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Per E. Gustafsson, Osvaldo Fonseca-Rodriguez, Ingeborg Nilsson, Miguel San Sebastian
Summary: This study in Sweden examined social inequalities in loneliness among older adults receiving eldercare, finding that inequalities particularly emerged at the intersection of country of birth, income, and residential setting. The COVID-19 pandemic slightly widened these inequalities in 2020, with nursing home residents emerging as a risk group. Discriminatory accuracy of the inequalities remained consistently low to moderate, but showed a slight increase during the pandemic.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Nutrition & Dietetics
Thomas Vogt, Per E. Gustafsson
Summary: This study investigated disparities in fruit and vegetable intake between groups at the intersection of education and gender in northern Sweden, and estimated the discriminatory accuracy of the intersectional groups. The results showed that low educated men had the highest prevalence of inadequate intake, while high educated women had the lowest. The joint disparities were mostly explained by gender and education, and suggestions for interventions and policies were made.
Article
Public, Environmental & Occupational Health
Frida Brattlof, Per E. Gustafsson, Miguel San Sebastian
Summary: This study examined the prevalence of physical activity and socioeconomic inequalities in Sweden before and during the COVID-19 pandemic. The findings showed that social inequalities increased during the pandemic across various socioeconomic factors, but not based on gender.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Alieu Sowe, Fredinah Namatovu, Bai Cham, Per E. Gustafsson
Summary: This study aimed to assess the impact of a timeliness monitoring intervention on hepatitis B birth dose administration in The Gambia. The results showed that the intervention led to overall improvements in birth dose timeliness, with a greater impact on poorly performing health facilities.
Article
Health Care Sciences & Services
Joel Lillqvist, Johan N. Sommar, Per E. Gustafsson, Eva-Lotta Glader, Katarina Hamberg, Olov Rolandsson
Summary: Groups with low socioeconomic status have lower rates of using medication that prevents cardiovascular disease, compared to groups with high socioeconomic status. Physicians are responsible for prescribing all medicines to prevent cardiovascular disease; thus, biased prescriptions could have effects on the equality of care in the population. Compared to individuals with equivalent education, physicians had higher rates of using medication that prevents cardiovascular disease.
SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
(2023)
Article
Substance Abuse
Noora Berg, Pekka Virtanen, Christopher G. Bean, Tomi Lintonen, Tapio Nummi, Anne Hammarstrom
ADDICTION RESEARCH & THEORY
(2020)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
