Article
Pharmacology & Pharmacy
Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Roger Gaedigk, Wiranpat Kittitharaphan, Nattawat Ngamsamut, Penkhae Limsila, Apichaya Puangpetch, Rattanaporn Sukprasong, Chonlaphat Sukasem
Summary: This study investigated the association between genetic variations in pharmacodynamic genes and risperidone-induced increased prolactin levels in ASD patients. Specific DRD2 diplotypes were found to be related to higher prolactin levels, suggesting a genetic risk score impact on prolactin levels. Additionally, patients who responded to risperidone had lower levels of prolactin.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Richard Houghton, Joop van den Bergh, Kiely Law, Yutong Liu, Frank de Vries
Summary: This study compared the risk of bone fractures among 6624 children with autism spectrum disorder (ASD), half of whom used risperidone and half of whom used aripiprazole. Taking other factors into account, risks were similar between the two groups throughout the first 180 days on treatment, but significantly higher in the aripiprazole group thereafter. The biggest differences were in lower leg and ankle fractures. Overall, compared with aripiprazole, risperidone was associated with 40% lower risk of fracture.
Review
Biochemistry & Molecular Biology
Ravi Philip Rajkumar
Summary: Psychological therapies are the first-line treatment for childhood disruptive behavior disorders (DBDs), but many patients require adjunctive pharmacotherapy. This paper summarizes the findings of existing systematic reviews and updates them with recent clinical trials on the use of antipsychotics in children and adolescents with DBDs. The data suggests that risperidone appears to be effective in the short-term management of DBDs, but all available antipsychotics are associated with metabolic adverse effects.
Article
Pharmacology & Pharmacy
Sanne Maartje Kloosterboer, Brenda C. M. de Winter, Catrien G. Reichart, Mirjam E. J. Kouijzer, Matthias M. J. de Kroon, Emma van Daalen, Wietske A. Ester, Rob Rieken, Gwen C. Dieleman, Daphne van Altena, Beatrijs Bartelds, Ron H. N. van Schaik, Kazem Nasserinejad, Manon H. J. Hillegers, Teun van Gelder, Bram Dierckx, Birgit C. P. Koch
Summary: The study found a relationship between risperidone plasma concentrations and body mass index, side effects, and effectiveness in children and adolescents with autism spectrum disorder. Higher risperidone sum trough concentrations were associated with higher BMI z-scores, sedation, and prolactin levels. Therapeutic drug monitoring of risperidone may improve safety and effectiveness in this population.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
L. Sikich, A. Kolevzon, B. H. King, C. J. McDougle, K. B. Sanders, S-J Kim, M. Spanos, T. Chandrasekhar, M. D. P. Trelles, C. M. Rockhill, M. L. Palumbo, A. Witters Cundiff, A. Montgomery, P. Siper, M. Minjarez, L. A. Nowinski, S. Marler, L. C. Shuffrey, C. Alderman, J. Weissman, B. Zappone, J. E. Mullett, H. Crosson, N. Hong, S. K. Siecinski, S. N. Giamberardino, S. Luo, L. She, M. Bhapkar, R. Dean, A. Scheer, J. L. Johnson, S. G. Gregory, J. Veenstra-VanderWeele
Summary: A randomized trial involving 290 participants with autism spectrum disorder showed that daily use of intranasal oxytocin did not improve social interaction over a period of 24 weeks. Overall, there were no significant between-group differences in social or cognitive functioning between the oxytocin and placebo groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Clinical Neurology
Alexander Kolevzon, Pamela Ventola, Christopher J. Keary, Gali Heimer, Jeffrey L. Neul, Mathews Adera, Judith Jaeger
Summary: The CGI-S/I-AS scales have been developed for use in clinical trials for Angelman syndrome, capturing six critical domains identified by caregivers and expert clinicians. Rigorous training and careful calibration have ensured the reliability of these adapted CGI scales in the context of randomized controlled trials, with the scales currently being utilized in a Phase 3 trial of gaboxadol for the treatment of AS.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2021)
Review
Psychiatry
Veronika Vasilevska, Paul C. Guest, Konstantin Schlaaff, Enise I. Incesoy, Harald Pruess, Johann Steiner
Summary: This study shows the biological links between inflammation and mental illness, as well as the interaction between the immune system and the brain, including the possible routes of viral entry into the brain. Additionally, it provides a stepwise scheme for the diagnosis and therapy of autoimmune-encephalitis with schizophrenia-like symptomatology, serving as a guide for clinical practice in infections.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Immunology
Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Min -Sun Kim
Summary: Cognitive impairment and organic solvent exposure are significant concerns in public health. This study investigated the therapeutic effects of risperidone on cognitive impairment caused by 1,2-diacetylbenzene (DAB) using in vivo and in silico methods. Risperidone was found to alleviate DAB-induced cognitive impairment through various molecular mechanisms, including inhibition of GSK-3β, amyloid-β, CDK5, BACE, and tau hyperphosphorylation. It also suppressed DAB-induced activation of inflammatory pathways and oxidative stress. In silico analyses identified the involvement of prolactin signaling, miRNA regulation, and CEBPB in the pathophysiology of DAB-induced cognitive impairment. These findings suggest the potential use of risperidone in treating cognitive impairment caused by organic solvents, particularly DAB.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Psychiatry
Marta Llorens, Maria Barba, Jordi Torralbas, Roser Nadal, Antonio Armario, Humberto Gagliano, Maria Betriu, Lara Urraca, Susana Pujol, Itziar Montalvo, Rebeca Gracia, Olga Gimenez-Palop, Diego Palao, Montserrat Pamias, Javier Labad
Summary: The study found that HPA axis hormone levels are associated with the severity of cognitive and inattention symptoms of patients with ADHD, and childhood maltreatment and sex exert distinct moderating effects depending on the symptom type.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Jingda Cai, Li Li, Tiannan Shao, Mengxi Sun, Weiyan Wang, Peng Xie, Xiaoyi Wang, Ye Yang, Yujun Long, Dongyu Kang, Jingmei Xiao, Yuhan Su, Xingjie Peng, Yuyan Huang, Menghui Gao, Qiongqiong Wu, Chuhan Song, Furu Liu, Ping Shao, Jianjun Ou, Yidong Shen, Jing Huang, Renrong Wu
Summary: Hyperprolactinemia and metabolic disturbance are common side effects of antipsychotics. This study investigated the relationship between antipsychotic switching, baseline clinical status, metabolic changes, and relapse in patients with schizophrenia. The results showed that patients with higher baseline symptoms were more likely to relapse, and switching to aripiprazole increased the risk of relapse regardless of the original medication. Changes in medication also had different effects on metabolic indices in patients with different baseline drugs.
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Milena Stojkovic, Branimir Radmanovic, Mirjana Jovanovic, Vladimir Janjic, Nemanja Muric, Dragana Ignjatovic Ristic
Summary: Risperidone is a commonly used antipsychotic medication known for its safety and efficacy in reducing psychotic symptoms. However, it can lead to non-selective side effects, including hyperprolactinemia, which can impair somatic functions and decrease quality of life. Recognizing and treating risperidone-induced hyperprolactinemia is crucial for improving patient outcomes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Wang Zhenhua, Chen Haizhi, Li Jing, Fei Xiaocong, Li Jianhua, Liu Jianjun, Lei Lilei, Jin Haiying
Summary: Risperidone and amisulpride can cause hyperprolactinemia and macroprolactinemia, and detection of MPRL in the clinical setting is important as this phenomenon appears early in treatment (the second week) and continues, which can prevent unnecessary examination and treatment for asymptomatic patients with macroprolactinemia.
ASIA-PACIFIC PSYCHIATRY
(2022)
Article
Pediatrics
Marco Colizzi, Riccardo Bortoletto, Leonardo Zoccante
Summary: Children and adolescents with Tourette syndrome may experience psychological and behavioral difficulties, with non-tic symptoms often requiring greater attention than tic symptoms.
Article
Clinical Neurology
Preeya J. Patel, Christian Weidenfeller, Andrew P. Jones, Jens Nilsson, Jay Hsu
Summary: The study evaluated the long-term effects of lurasidone in patients with schizophrenia through post hoc analysis of a DB active control trial and an OLE study. Lurasidone was found to be generally well tolerated and effective in clinically stable schizophrenia patients over the long term, with minimal changes in metabolic variables and prolactin levels compared to risperidone. Patients switching from risperidone to lurasidone also experienced improvements in metabolic parameters and prolactin levels.
NEUROLOGY AND THERAPY
(2021)
Review
Psychology, Developmental
Dominik Staempfli, Stefan Weiler, Andrea M. Burden
Summary: The study summarized 13 published case reports and analyzed 25,556 adverse drug event reports from the WHO, indicating that the risk of movement disorders may be increased when methylphenidate and risperidone are used in combination.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Review
Psychiatry
Julia Machado Khoury, Maila de Castro Lourenco das Neves, Marco Antonio Valente Roque, Daniela Alves de Brito Queiroz, Andre Augusto Correa de Freitas, Angelo de Fatima, Fabricio A. Moreira, Frederico Duarte Garcia
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Article
Multidisciplinary Sciences
Julia Machado Khoury, Andre Augusto Correa de Freitas, Marco Antonio Valente Roque, Maicon Rodrigues Albuquerque, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia
Article
Psychiatry
Julia Machado Khoury, Luiz Filipe Silva Codorino Couto, Douglas de Almeida Santos, Vitor Hugo de Oliveira e Silva, Joao Pedro Sousa Drumond, Leticia Lopes de Carvalho e Silva, Leandro Malloy-Diniz, Maicon Rodrigues Albuquerque, Maila de Castro Lourengo das Neves, Frederico Duarte Garcia
FRONTIERS IN PSYCHIATRY
(2019)
Correction
Psychiatry
Julia Machado Khoury, Luiz Filipe Silva Codorino Couto, Douglas de Almeida Santos, Vitor Hugo de Oliveira e Silva, Joao Pedro Sousa Drumond, Leticia Lopes de Carvalho e Silva, Leandro Malloy-Diniz, Maicon Rodrigues Albuquerqu, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia
FRONTIERS IN PSYCHIATRY
(2019)
Article
Nutrition & Dietetics
Marta Paula Pereira Coelho, Kiara Goncalves Dias Diniz, Tatiana Bering, Lucas dos Santos Athadeu Ferreira, Diego Alves Vieira, Manuela Resende Costa Castro, Maria Isabel Toulson Davidson Correia, Gifone Aguiar Rocha, Rosangela Teixeira, Frederico Duarte Garcia, Luciana Diniz Silva
Article
Psychiatry
Ananda A. Teixeira, Marco A. Roque, Andre A. de Freitas, Nicole F. dos Santos, Flavia M. Garcia, Julia M. Khoury, Maicon R. Albuquerque, Maila de C. das Neves, Frederico D. Garcia
Summary: This study validated a Brazilian Portuguese version of the SCOFF questionnaire for screening eating disorders in young adults, showing satisfactory sensitivity, specificity, and accuracy in the Brazilian university community.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Psychiatry
Maila de C. das Neves, Ananda A. Teixeira, Flavia M. Garcia, Joel Renno, Antonio G. da Silva, Amaury Cantilino, Carlos E. Rosa, Jeronimo de A. Mendes-Ribeiro, Renan Rocha, Hewdy Lobo, Igor E. Gomes, Christiane C. Ribeiro, Frederico D. Garcia
Summary: This study systematically reviewed the literature on the obstetric and perinatal outcomes in women with eating disorders, and the consequences for their offspring. The findings suggest that eating disorders can lead to poor outcomes during pregnancy and childbirth, as well as affecting the health of the newborn. Obstetricians and general practitioners should be vigilant in screening for eating disorders during pregnancy.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Correction
Biochemistry & Molecular Biology
Paulo Sergio de Almeida Augusto, Raissa Lima Goncalves Pereira, Sordaini Maria Caligiorne, Brian Sabato, Bruna Rodrigues Dias Assis, Larissa Pires do Espirito Santo, Karine Dias dos Reis, Gisele Assis Castro Goulart, Angelo de Fatima, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Paulo Sergio de Almeida Augusto, Raissa Lima Goncalves Pereira, Sordaini Maria Caligiorne, Brian Sabato, Bruna Rodrigues Dias Assis, Larissa Pires do Espirito Santo, Karine Dias dos Reis, Gisele Assis Castro Goulart, Angelo de Fatima, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia
Summary: Protecting children from prenatal cocaine exposure is a significant challenge, but using anti-cocaine vaccines may be effective in reducing this risk. The study demonstrates the potential of GNE-KLH anti-cocaine vaccine to produce and maintain antibodies that protect against prenatal cocaine damage during pregnancy. Further research is needed to understand the mechanisms behind the protective effects of anti-cocaine antibodies in pregnancy.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Psychiatry
Devon Watts, Frederico D. Garcia, Acioly L. T. Lacerda, Jair de J. Mari, Lucas C. Quarantini, Flavio Kapczinski
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Leonardo da Silva Neto, Angelica Faleiros da Silva Maia, Adriana Martins Godin, Paulo Sergio de Almeida Augusto, Raissa Lima Goncalves Pereira, Sordaini Maria Caligiorne, Rosemeire Brondi Alves, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Gisele Assis Castro Goulart, Felipe Terra Martins, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia, Angelo de Fatima
Summary: The study introduces two novel calix[n]arene-based anti-cocaine immunogens (V4N2 and V8N2) and evaluates their preclinical efficacy. The immunogens induce high titers of cocaine antibodies and modify the biodistribution of a cocaine analogue, reducing cocaine-induced behavior. These findings demonstrate the potential of V4N2 and V8N2 as immunogens for the treatment of cocaine use disorder.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Music
Frederico Goncalves Pedrosa, Frederico Duarte Garcia, Cybelle Maria Veiga Loureiro
Summary: Chemical dependencies are diseases that affect cognitive, social and neurological aspects, caused by the abuse of non-organism-produced substances. This review examined the use of music therapy in the context of chemical dependency and concluded that there is a lack of standardization in the evaluation of outcomes, but some insights were gained regarding its impact on the psychological aspects of patients.
Article
Immunology
Brian Sabato, Paulo Sergio de Almeida Augusto, Raissa Lima Gonsalves Pereira, Felipe Coutinho Batista Esteves, Sordaini M. Caligiorne, Bruna Rodrigues Dias Assis, Sostenes Apolo Correia Marcelino, Larissa Pires do Espirito Santo, Karine Dias dos Reis, Leonardo Da Silva Neto, Gisele Goulart, Angelo de Fatima, Felipe Pierezan, Ricardo Toshio Fujiwara, Maila Castro, Frederico Garcia
Summary: An effective method for treating cocaine addiction is the use of anti-drug vaccines. These vaccines stimulate the production of antibodies that can bind to cocaine and reduce its passage through the blood-brain barrier, thereby decreasing its activity in the brain. A new vaccine candidate, UFMG-V4N2, was developed by our research group using an innovative carrier based on calixarenes. Safety and immunogenicity of the anti-cocaine vaccine were assessed in non-human primates, and it was found that UFMG-VAC-V4N2 had minimal side effects and did not affect general health or other physiological parameters. This preclinical study provides important evidence for future clinical trials of the anti-cocaine vaccine.
Article
Psychiatry
Julia Machado Khoury, Maila de Castro Lourenco dos Neves, Marco Antonio Valente Roque, Andre Augusto Correa de Freitas, Michele Ralil da Costa, Frederico Duarte Garcia
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2019)
Article
Psychiatry
Felipe Jose Nascimento Barreto, Frederico Duarte Garcia, Paulo Henrique Teixeira Prado, Paulo Marcos Brasil Rocha, Nadia Souza Las Casas, Felipe Barbosa Vallt, Humberto Correa, Maila Castro Lourenco Neves
WORLD JOURNAL OF PSYCHIATRY
(2017)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
