Article
Clinical Neurology
Helena R. Bean, Justine Diggens, Maria Ftanou, Marliese Alexander, Lesley Stafford, Bei Bei, Prudence A. Francis, Joshua F. Wiley
Summary: This study evaluated the effects of combined brief cognitive behavioral therapy and bright light therapy on insomnia symptoms and sleep efficiency in breast cancer patients undergoing chemotherapy. The results showed that the CBT-I + Light group had greater improvement in insomnia symptoms, sleep efficiency, fatigue, and daytime sleep-related impairment compared to the treatment as usual group.
Review
Oncology
Lucy R. Haggstrom, Janette L. Vardy, Emma-Kate Carson, Davendra Segara, Elgene Lim, Belinda E. Kiely
Summary: This review focuses on cognitive dysfunction associated with endocrine therapy for breast cancer, aiming to provide evidence-based management strategies. Endocrine therapy is a crucial treatment for breast cancer patients, but its side effects can negatively impact quality of life, treatment adherence, and outcomes. Cognitive adverse effects are common but often underreported and challenging to manage. Therefore, proactive management by a multidisciplinary team is essential to promote adherence and improve patients' quality of life.
Article
Medical Informatics
Claire M. Starling, Daniel Greenberg, Eric Zhou, Daniel Lewin, Allison S. Morrow, Daniel Lieberman, Callen Shaw, Hannah Arem
Summary: This article describes a study on insomnia symptoms in breast cancer survivors. The study uses voice-activated delivery of cognitive behavioral therapy for insomnia (CBT-I) to explore its efficacy in alleviating insomnia symptoms.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Review
Oncology
Laura Oldacres, Josephine Hegarty, Patricia O'Regan, Noreen M. Murphy-Coakley, Mohamad M. Saab
Summary: This study examined interventions used to enhance cognitive function in patients with cancer-related cognitive impairment. A total of 31 studies were analyzed and various interventions were identified, including integrative/complementary, cognitive behavioral therapy and compensatory strategies, exercise, psychoeducational/psychosocial, brain-training, and pharmacological approaches. However, the measurement of outcomes was inconsistent, making it difficult to draw definitive conclusions. Future research should prioritize the use of standardized measures to evaluate the effectiveness of interventions.
Article
Psychology, Multidisciplinary
Thomas West, Corrado Cavallero, Rita Ceccherini, Silva Foladore, Daniele Generali, Francesco Versace, Bruna Scaggiante
Summary: The study aimed to determine the prevalence rate of cancer related cognitive impairment in Italian breast cancer patients and evaluate the implications of specific behavioral factors. Results showed a higher prevalence of cognitive complaints, lower cognitive reserve, and worse sleep quality in breast cancer patients compared to age-matched controls. Future research on behavioral interventions is needed to prevent subjective cognitive deficits in breast cancer patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
H. J. Burstein, G. Curigliano, B. Thurlimann, W. P. Weber, P. Poortmans, M. M. Regan, H. J. Senn, E. P. Winer, M. Gnant
Summary: The 17th St Gallen International Breast Cancer Consensus Conference in 2021 was held virtually, with over 3300 participants discussing key issues related to early breast cancer diagnosis and treatment. The conference emphasized customized recommendations for breast cancer treatment, highlighting the importance of individualized clinical features in patient care.
ANNALS OF ONCOLOGY
(2021)
Review
Oncology
Kate G. Blumenstein, Anna Brose, Chris Kemp, Dalton Meister, Emily Walling, Adam S. DuVall, Anao Zhang
Summary: This study conducted a systematic review and meta-analysis to examine the impact of cognitive-behavioral therapy (CBT) on functional health outcomes in cancer survivors. The results showed that CBT was effective at improving functional health outcomes in cancer survivors, regardless of therapy delivery modality or number of cancer diagnoses. However, it did not have an impact on newly diagnosed patients or those currently benefiting from an active comparator intervention.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Giuseppe Curigliano, Fatima Cardoso, Michael Gnant, Nadia Harbeck, Judy King, Anne-Vibeke Laenkholm, Frederique Penault-Llorca, Aleix Prat
Summary: Breast cancer multigene signatures (BCMS) have changed the management of early-stage breast cancer (eBC) by providing prognostic information and helping select patients for adjuvant chemotherapy. However, there is limited knowledge on the current usage and perceived utility of BCMS in clinical practice. A two-round Delphi survey involving 133 breast cancer experts from 11 European countries revealed that BCMS are widely used to assess risk of recurrence and select patients for adjuvant chemotherapy, but consensus is lacking regarding their utility in selecting specific chemotherapy types. There are also discrepancies between recommended usage and actual usage, with some profiles lacking supporting evidence. The study suggests the need for physician education initiatives to ensure proper use and interpretation of BCMS, ultimately improving management of eBC patients.
Article
Oncology
Cody Ramin, Lene H. S. Veiga, Jacqueline B. Vo, Rochelle E. Curtis, Clara Bodelon, Erin J. Aiello Bowles, Diana S. M. Buist, Sheila Weinmann, Heather Spencer Feigelson, Gretchen L. Gierach, Amy Berrington de Gonzalez
Summary: Breast cancer survivors treated in recent decades have an increased risk of developing second primary cancers. This study found that they had a 70% higher risk of any cancer and a 45% higher risk of non-breast cancer compared to the general population. Enhanced surveillance and efforts to reduce the occurrence of second cancers are needed for breast cancer survivors.
BREAST CANCER RESEARCH
(2023)
Article
Psychology, Clinical
James C. Root, Alexandra M. Gaynor, Anam Ahsan, Duane Jung, Elizabeth Schofield, Elizabeth Ryan, Yuelin Li, Tim A. Ahles
Summary: The study aimed to develop the Cogsuite battery for improved sensitivity to cancer-related cognitive dysfunction (CRCD) in breast cancer survivors. The battery was found to be reliable, valid, and sensitive to the effects of increasing age on cognition. Adding the Cogsuite battery to standard assessment may enhance sensitivity to CRCD and identify underlying processes, while remote use of the battery will alleviate burden in research and clinical contexts.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Oncology
Alexandra M. Gaynor, Anam Ahsan, Duane Jung, Elizabeth Schofield, Yuelin Li, Elizabeth Ryan, Tim A. Ahles, James C. Root
Summary: This study evaluated the ability of a novel computerized battery of cognitive neuroscience-based tests to distinguish cognitive performance between breast cancer survivors and controls. The results showed that survivors had lower performance in multiple cognitive domains compared to controls. The battery demonstrated sensitivity to cancer-related cognitive dysfunction and identified specific cognitive processes that may be affected in survivors. This has implications for the initial diagnosis and monitoring of cognitive function in cancer survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Medicine, Research & Experimental
Anne Lukas, Maurice Theunissen, Dianne de Korte-de Boer, Sander van Kuijk, Lotte Van Noyen, Walter Magerl, Werner Mess, Wolfgang Buhre, Madelon Peters
Summary: Survivors of breast cancer often suffer from persistent pain after treatment, which greatly reduces their quality of life. The AMAZONE study aims to investigate the effect of online cognitive behavioral therapy (e-CBT) on the prevalence of persistent pain after breast cancer treatment (PPBCT). In addition, the study also aims to unravel the underlying pathophysiological mechanisms of PPBCT.
Review
Clinical Neurology
Yan Ma, Daniel L. Hall, Long H. Ngo, Qingqing Liu, Paul A. Bain, Gloria Y. Yeh
Summary: Insomnia is highly prevalent in breast cancer patients, and cognitive behavioral therapy for insomnia (CBT-I) has been shown to be effective in reducing insomnia and improving sleep quality in women treated for breast cancer. The study found that CBT-I had significant effects at post-intervention, short-term follow-up, and long-term follow-up. Future research should focus on investigating the optimal integration of CBT-I components to manage insomnia during breast cancer survivorship.
SLEEP MEDICINE REVIEWS
(2021)
Review
Oncology
So-Young Park, Jung-Won Lim
Summary: This study systematically reviewed the evidence from randomized controlled trials (RCTs) of cognitive behavioral therapy (CBT) designed to reduce fear of cancer recurrence (FCR) among breast cancer survivors (BCSs). The findings suggest that face-to-face interventions lasting at least 1 month were more effective and better complied with the CONSORT 2010 criteria than brief online or telephone interventions. Overall, most interventions appeared to be effective.
Article
Psychology, Clinical
Jennifer L. Kilkus
Summary: There are over 17 million cancer survivors in the United States, who often face longstanding psychological and physiological effects. Successful recovery requires adequate management of side effects, integration of cultural considerations, and effective navigation of systemic healthcare issues. Cognitive behavioral therapy is a particularly useful intervention in cancer survivorship, tailored to address individual concerns within a cultural and societal context.
Article
Health Care Sciences & Services
Kea Turner, Margarita Bobonis Babilonia, Cristina Naso, Oliver Nguyen, Brian D. Gonzalez, Laura B. Oswald, Edmondo Robinson, Jennifer Elston Lafata, Robert J. Ferguson, Amir Alishahi Tabriz, Krupal B. Patel, Julie Hallanger-Johnson, Nasrin Aldawoodi, Young-Rock Hong, Heather S. L. Jim, Philippe E. Spiess
Summary: This qualitative study explored the experiences of oncology healthcare providers and professionals (HPPs) with telehealth implementation during the COVID-19 pandemic. The study identified five key themes, including establishing patient-HPP relationships, coordinating care with other HPPs and informal caregivers, adapting in-person assessments for telehealth, developing workflows and allocating resources, and making future recommendations. Participants described innovative strategies for telehealth implementation and discussed challenges such as workflow integration and lack of physical exam and biometric data.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Geriatrics & Gerontology
Brea L. Perry, Adam R. Roth, Siyun Peng, Shannon L. Risacher, Andrew J. Saykin, Liana G. Apostolova
Summary: Social network attributes moderate the association between amygdalar volume and cognitive function. Participants with diverse and loosely connected social networks have better cognitive function regardless of amygdalar volume. These findings suggest that interacting with multiple social relationships can promote cognitive reserve.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Computer Science, Artificial Intelligence
Mansu Kim, Eun Jeong Min, Kefei Liu, Jingwen Yan, Andrew J. Saykin, Jason H. Moore, Qi Long, Li Shen
Summary: In this study, a novel multi-task learning based structured sparse canonical correlation analysis (MTS2CCA) was proposed to deliver interpretable results and improve integration in imaging genetics studies. The proposed model outperformed state-of-the-art competing methods on both simulation and real imaging genetic data in terms of feature selection accuracy and performance, revealing promising features related to sleep on real imaging genetic data.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Oncology
Rachelle Brick, Kathleen Doyle Lyons, Catherine Bender, Rachel Eilers, Robert Ferguson, Mackenzi Pergolotti, Pamela Toto, Elizabeth Skidmore, Natalie E. Leland
Summary: The study found that older breast cancer survivors consider multiple factors when deciding whether to utilize cancer rehabilitation services, including awareness of disability, coping styles, social support, etc. Development of shared decision-making tools can enhance communication and referral to cancer rehabilitation services.
SUPPORTIVE CARE IN CANCER
(2022)
Correction
Clinical Neurology
Jun Pyo Kim, Bo-Hyun Kim, Paula J. Bice, Sang Won Seo, David A. Bennett, Andrew J. Saykin, Kwangsik Nho
Summary: An amendment to this paper has been published and can be accessed via the original article.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Peripheral Vascular Disease
Isabel J. Sible, Daniel A. Nation
Summary: This study found that blood pressure variability (BPV) in older adults is related to tau accumulation in brain regions vulnerable to Alzheimer's disease, independent of average blood pressure levels. The relationship is modified by APOE ε4 carrier status. BPV may serve as a marker of vascular dysfunction contributing to early-stage tau pathology in Alzheimer's disease.
Review
Oncology
Rachelle Brick, Rose Turner, Catherine Bender, Madilyn Douglas, Rachel Eilers, Robert Ferguson, Natalie Leland, Kathleen D. Lyons, Pamela Toto, Elizabeth Skidmore
Summary: Cancer-related disability is a complex problem for older breast cancer survivors, with limited understanding of how interventions influence activity limitations and participation restrictions. Current research suggests that exercise and behavioral strategies can be effective nonpharmacological interventions. However, the study samples are not representative of the actual population, and future research should focus on clarifying and comprehensively measuring intervention measures.
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Article
Neurosciences
Jun Pyo Kim, Bo-Hyun Kim, Paula J. Bice, Sang Won Seo, David A. Bennett, Andrew J. Saykin, Kwangsik Nho
Summary: Through analysis of data from two independent cohorts, we found that DNA methylation alterations may be involved in Alzheimer's disease (AD), and identified 15 key CpG sites associated with AD pathology.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Oncology
Rachelle Brick, Elizabeth Skidmore, Catherine Bender, Robert Ferguson, Mackenzi Pergolotti, Pamela Toto, Natalie Leland
Summary: This study aimed to improve accessibility of rehabilitation interventions for older breast cancer survivors by determining the content and delivery features through expert consensus. Experts prioritized physical activity strategies and adaptive skills training. They also identified outpatient services, post-treatment delivery, combination mode, short duration, and one to two days per week frequency as important factors in improving accessibility.
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Review
Neuroimaging
Cecily G. Swinford, Shannon L. Risacher, Yu-Chien Wu, Liana G. Apostolova, Sujuan Gao, Paula J. Bice, Andrew J. Saykin
Summary: The prevalence of Alzheimer's disease in the U.S. is expected to reach 13 million by 2050. Currently, there are no treatments available to stop or reverse the progressive cognitive decline associated with the disease. Preventive treatment before significant cognitive decline occurs may be the solution, but there is a need for a reliable biomarker to identify older adults at highest risk. Quantitative cerebral blood flow shows promise as a potential early biomarker for Alzheimer's disease, but further research is needed to fully understand the patterns of altered blood flow.
BRAIN IMAGING AND BEHAVIOR
(2023)
Letter
Clinical Neurology
Jung-Min Pyun, Young Ho Park, Jiebiao Wang, Paula J. Bice, David A. Bennett, SangYun Kim, Andrew J. Saykin, Kwangsik Nho
ANNALS OF NEUROLOGY
(2023)
Article
Oncology
Kelly Nudelman, Kwangsik Nho, Michael Zhang, Brenna C. McDonald, Wanting Zhai, Brent J. Small, Claire E. Wegel, Paul B. Jacobsen, Heather S. L. Jim, Sunita K. Patel, Deena M. A. Graham, Tim A. Ahles, James C. Root, Tatiana Foroud, Elizabeth C. Breen, Judith E. Carroll, Jeanne S. Mandelblatt, Andrew J. Saykin
Summary: This study found that genetics may play an important role in modifying risk for cognitive decline in older female breast cancer survivors. Several genetic variants and genes were identified to be associated with differences in patterns of cognitive decline in cancer patients compared to controls. Further research and validation of these findings in other cancer populations is necessary to inform therapeutic research and evaluations of risk for cognitive decline in older cancer survivors.
Article
Cell Biology
Rafi Haque, Caroline M. Watson, Jiaqi Liu, E. Kathleen Carter, Duc M. Duong, James J. Lah, Aliza P. Wingo, Blaine R. Roberts, Erik C. B. Johnson, Andrew J. Saykin, Leslie M. Shaw, Nicholas T. Seyfried, Thomas S. Wingo, Allan I. Levey
Summary: This study developed a reliable and high-throughput mass spectrometry assay to detect 48 key proteins in cerebrospinal fluid (CSF), and found that this panel of proteins performed at least as well as existing biomarkers in predicting clinical diagnosis, brain imaging results, cognitive decline, and dementia severity in Alzheimer's disease. Combining this panel with existing biomarkers significantly improved diagnostic accuracy and prediction of disease progression.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Genetics & Heredity
Thea J. Rosewood, Kwangsik Nho, Shannon L. Risacher, Sujuan Gao, Li Shen, Tatiana Foroud, Andrew J. Saykin
Summary: The genetic susceptibility for Alzheimer's disease (AD) is not fully understood. This study used an endophenotype approach to identify genetic associations and discovered novel genetic loci related to AD. These findings provide deeper insights into the genetic mechanisms underlying AD.
Article
Sport Sciences
Edward Simpson, Jill L. Reiter, Jie Ren, Zhiqi Zhang, Kelly N. Nudelman, Larry D. Riggen Jr, Michael D. Menser, Jaroslaw Harezlak, Tatiana M. Foroud, Andrew J. Saykin, Alison Brooks, Kenneth L. Cameron, Stefan M. Duma, Gerald Mcginty, Steven Rowson, Steven J. Svoboda, Steven P. Broglio, Michael A. McCrea, Paul F. Pasquina, Thomas W. Mcallister, Yunlong Liu, CARE Consortium Investigators
Summary: This study analyzed the gene expression changes in peripheral blood following concussion in collegiate athletes. The results showed immediate activation of cytokine and immune response signaling pathways, which later seemed to be suppressed. Additionally, the study found an increase in neutrophils and a decrease in natural killer cells in the blood following concussion.
