Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Oncology
Kimberly W. Keefe, Andrea Lanes, Kayla Stratton, Daniel M. Green, Eric J. Chow, Kevin C. Oeffinger, Sara Barton, Lisa Diller, Yutaka Yasui, Wendy M. Leisenring, Gregory T. Armstrong, Elizabeth S. Ginsburg
Summary: Linking the Childhood Cancer Survivor Study database to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System revealed that childhood cancer survivors are as likely to undergo treatment with assisted reproductive technology as their siblings. The success of assisted reproductive technology was not reduced after alkylator exposure.
Article
Oncology
Timothy J. D. Ohlsen, Huiqi Wang, David Buchbinder, I-Chan Huang, Arti D. Desai, Zhiyuan Zheng, Anne C. Kirchhoff, Elyse R. Park, Kevin Krull, Rena M. Conti, Yutaka Yasui, Wendy Leisenring, Gregory T. Armstrong, K. Robin Yabroff, Paul C. Nathan, Eric J. Chow
Summary: Adult siblings of childhood cancer survivors may experience greater aspects of financial hardship compared with the general population. Childhood cancer may adversely affect entire households, with potentially lasting implications.
Article
Oncology
John L. Jefferies, Wojciech M. Mazur, Carrie R. Howell, Juan C. Plana, Kirsten K. Ness, Zhenghong Li, Vijaya M. Joshi, Daniel M. Green, Daniel A. Mulrooney, Jeffrey A. Towbin, Hugo R. Martinez, Jason F. Goldberg, Rebecca M. Howell, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Gregory T. Armstrong
Summary: Limited data exist regarding left ventricular remodeling patterns observed in adult survivors of childhood cancer after therapy. Among survivors, chest radiation therapy increases the risk for concentric remodeling while it is associated with decreased exercise intolerance.
Article
Hematology
Andrew D. Meyer, Tyler B. Hughes, Anjana R. Rishmawi, Patty Heard, Shafqat Shah, Gregory J. Aune
Summary: Cancer survivors, especially children, have an increased risk of thromboembolism and exhibit a procoagulant state characterized by lower platelet count, shorter prothrombin time, and elevated procoagulant biomarkers such as TAT and PAI. This chronic hypercoagulable state persists for more than five years after diagnosis and may contribute to the increased risk of thromboembolism in childhood cancer survivors.
THROMBOSIS RESEARCH
(2023)
Article
Oncology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet Van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline Van Dulmen-den Broeder, Marry M. Van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Arend Bokenkamp, Margreet A. Veening
Summary: This study investigated the occurrence of tubular dysfunction in childhood cancer survivors who received nephrotoxic therapy. The overall prevalence of electrolyte losses in survivors was not higher compared to controls, but some survivors had an increased risk of tubular dysfunction, especially those treated with specific chemotherapeutic agents. Therefore, these patients should be closely monitored during follow-up.
Article
Urology & Nephrology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline van Dulmen den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Margreet A. Veening, Arend Bokenkamp
Summary: This study aimed to evaluate glomerular dysfunction among childhood cancer survivors compared to a control group. It found a higher risk of chronic kidney disease and albuminuria in survivors, and identified several risk factors associated with these conditions. Therefore, lifelong monitoring of glomerular function is necessary for these survivors.
KIDNEY INTERNATIONAL
(2022)
Article
Oncology
Sonia Morales, Sedigheh Mirzaei Salehabadi, Deokumar Srivastava, Todd M. Gibson, Wendy M. Leisenring, Melissa A. Alderfer, E. Anne Lown, Lonnie K. Zeltzer, Gregory T. Armstrong, Kevin R. Krull, David Buchbinder
Summary: The study found that concerns about future health and cancer risk among siblings of childhood cancer survivors have decreased in recent decades, but there are still at-risk subgroups. Routine screening and monitoring of at-risk siblings of childhood cancer survivors may be beneficial for early intervention and support.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Review
Public, Environmental & Occupational Health
Tegan J. Reeves, Taylor J. Mathis, Hailey E. Bauer, Melissa M. Hudson, Leslie L. Robison, Zhaoming Wang, Justin N. Baker, I-Chan Huang
Summary: This scoping review highlighted significant health disparities between racial/ethnic minority and non-minority childhood cancer survivors, with factors such as clinical, demographic, and socioeconomic status playing a role in explaining these disparities. Comprehensive social determinants of racial/ethnic disparities should be collected and integrated into healthcare systems to better understand and address the gap. National and local efforts, such as improving health insurance access and providing culturally-specific interventions, are recommended to reduce the disparities in health outcomes for childhood cancer survivors of different racial/ethnic backgrounds.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Oncology
Bryan Dieffenbach, Qi Liu, Andrew J. Murphy, Deborah R. Stein, Natalie Wu, Arin L. Madenci, Wendy M. Leisenring, Nina S. Kadan-Lottick, Emily R. Christison-Lagay, Robert E. Goldsby, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Yutaka Yasui, Gregory T. Armstrong, Christopher B. Weldon, Eric J. Chow, Brent R. Weil
Summary: This study investigated the incidence of late-onset kidney failure among childhood cancer survivors and found that factors such as high kidney dose from radiotherapy, high-dose anthracycline, any ifosfamide chemotherapy, and nephrectomy were associated with an increased risk. Successfully managing modifiable risk factors like diabetes and hypertension could help reduce the risk of late-onset kidney failure. The association of late-onset kidney failure with anthracycline chemotherapy is a novel finding that requires further study.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Peter H. Asdahl, Kevin C. Oeffinger, Vanna Albieri, Melissa Hudson, Wendy M. Leisenring, Sarah S. Donaldson, Henrik Hasle, Jeanette F. Winther, Gregory T. Armstrong, Leslie L. Robison
Summary: Among childhood cancer survivors, the prevalence of esophageal strictures is 2.0%, which is significantly higher than in siblings. Risk factors for esophageal stricture include diagnosis of Hodgkin lymphoma, higher chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. Although rare, survivors are at risk for therapy-related esophageal strictures.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Ingrid Tonning Olsson, Nicole M. Alberts, Chenghong Li, Matthew J. Ehrhardt, Daniel A. Mulrooney, Wei Liu, Alberto S. Pappo, Michael W. Bishop, Doralina L. Anghelescu, Deokumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness, Kevin R. Krull, Tara M. Brinkman
Summary: Survivors of childhood cancer are at risk of chronic pain, which is associated with impaired neurocognition, physical performance, social functioning, and health-related quality of life. Screening for pain and interventions targeting pain interference are essential for improving the overall well-being of these survivors.
Article
Hematology
David Buchbinder, Neel S. Bhatt, Huiqi Wang, Yutaka Yasui, Saro Armenian, Smita Bhatia, Eric J. Chow, I. -Chan Huang, Anne C. Kirchoff, Wendy Leisenring, Elyse R. Park, K. Robin Yabroff, Gregory T. Armstrong, Paul C. Nathan, Nandita Khera
Summary: Long-term survivors of childhood cancer who received hematopoietic cell transplantation (HCT) do not report greater overall financial hardship compared to non-HCT survivors, but they do report greater overall financial hardship compared to sibling controls. Factors such as household income and chronic health conditions, rather than HCT, are associated with financial hardship among all survivors.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Oncology
Douglas Fair, Elyse R. Park, Ryan D. Nipp, Julia Rabin, Kelly Hyland, Karen Kuhlthau, Giselle K. Perez, Paul C. Nathan, Gregory T. Armstrong, Kevin C. Oeffinger, Leslie L. Robison, Wendy Leisenring, Anne C. Kirchhoff
Summary: The study found that survivors of childhood cancer and siblings did not significantly differ in the intensity of financial hardship. Insurance was found to be protective against financial hardship. Older age at diagnosis, female gender, chronic health conditions, and treatment with brain radiation or alkylating agents were associated with higher levels of financial hardship.
Article
Oncology
Brent R. Weil, Andrew J. Murphy, Qi Liu, Rebecca M. Howell, Susan A. Smith, Christopher B. Weldon, Elizabeth A. Mullen, Arin L. Madenci, Wendy M. Leisenring, Joseph P. Neglia, Lucie M. Turcotte, Kevin C. Oeffinger, Amanda M. Termuhlen, Sogol Mostoufi-Moab, Jennifer M. Levine, Kevin R. Krull, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Saro H. Armenian
Summary: This study evaluated long-term morbidity and mortality rates among unilateral, nonsyndromic Wilms tumor (WT) survivors based on conventional treatment regimens. The results showed that survivors in different treatment groups were at risk for late mortality and chronic health conditions, especially an elevated risk for intestinal obstruction and kidney failure. The intensity of treatment was associated with an increased risk for severe chronic health conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chantel Cacciotti, Lydia Larocque Chevalier, Cheryl Medeiros-Nancarrow, Christopher Recklitis, Tabitha M. Cooney
Summary: The identity of adult survivors of pediatric CNS tumors is linked to their health outcomes, with survivor identity associated with diagnosis and treatment, while victim identity is associated with poorer mental health. Frequency of thoughts of diagnosis is significantly associated with poorer mental health, anxiety, depression, and neurocognitive impairments. Understanding the unique features of identity in this population is important for patient-centered care.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Psychology, Social
Lydia L. Chevalier, Elizabeth Fine, Aditi Sharma, Eric S. Zhou, Christopher J. Recklitis
Summary: Insomnia is a common late effect of cancer, but many survivors have limited access to effective treatment. To address this issue, researchers developed a single-session intervention for insomnia after cancer. Preliminary results demonstrate the potential effectiveness of this program in improving survivors' insomnia symptoms.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2023)
Article
Hematology
Lucie M. Turcotte, Jillian A. Whitton, Wendy M. Leisenring, Rebecca M. Howell, Joseph P. Neglia, Rachel Phelan, Kevin C. Oeffinger, Kirsten K. Ness, William G. Woods, E. Anders Kolb, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow
Summary: The five-year survival rate for childhood acute myeloid leukemia (AML) has increased due to advancements in treatment and supportive care. However, the long-term health outcomes of AML survivors remain unclear. This study examined the incidence of late mortality and chronic health conditions (CHC) among 5-year AML survivors diagnosed between 1970 and 1999. The results showed that hematopoietic cell transplantation (HCT) was associated with higher late mortality, but the incidence of CHC has decreased over time for all treatment groups.
Article
Oncology
F. Lennie Wong, Janie M. Lee, Wendy M. Leisenring, Joseph P. Neglia, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Chaya S. Moskowitz, Tara O. Henderson, Ann Mertens, Paul C. Nathan, Yutaka Yasui, Wendy Landier, Gregory T. Armstrong, Leslie L. Robison, Smita Bhatia
Summary: This study evaluated the outcomes and cost-effectiveness of breast cancer screening using mammography and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hodgkin lymphoma survivors. The results showed that annual mammography screening at age 30-74 years is effective and cost-effective in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Paul C. Nathan, I-Chan Huang, Yan Chen, Tara O. Henderson, Elyse R. Park, Anne C. Kirchhoff, Leslie L. Robison, Kevin Krull, Wendy Leisenring, Gregory T. Armstrong, Rena M. Conti, Yutaka Yasui, K. Robin Yabroff
Summary: This study aimed to estimate the prevalence of financial hardship among adult survivors of childhood cancer compared with siblings and identify the correlates of hardship. The results showed that survivors were more likely to experience financial hardship compared to siblings.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychology, Developmental
Anne Kazak, Alejandra Perez Ramirez, Michele A. Scialla, Melissa A. Alderfer, Carrie Sewell-Roberts, Diane Treadwell-Deering
Summary: This study investigated the psychosocial risks faced by families of children with Autism Spectrum Disorder (ASD) and adapted an existing assessment tool to provide a promising means of evaluating these risks. The tool, called PAT-ASD, was implemented in a pilot study and showed positive results, although further validation is needed.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Oncology
Brent R. Weil, Andrew J. Murphy, Qi Liu, Rebecca M. Howell, Susan A. Smith, Christopher B. Weldon, Elizabeth A. Mullen, Arin L. Madenci, Wendy M. Leisenring, Joseph P. Neglia, Lucie M. Turcotte, Kevin C. Oeffinger, Amanda M. Termuhlen, Sogol Mostoufi-Moab, Jennifer M. Levine, Kevin R. Krull, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Saro H. Armenian
Summary: This study evaluated long-term morbidity and mortality rates among unilateral, nonsyndromic Wilms tumor (WT) survivors based on conventional treatment regimens. The results showed that survivors in different treatment groups were at risk for late mortality and chronic health conditions, especially an elevated risk for intestinal obstruction and kidney failure. The intensity of treatment was associated with an increased risk for severe chronic health conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Kathryn A. Davis, Phoebe Brosnan, Marcella Mazzenga, David Buchbinder, Melissa A. Alderfer, Christina M. Sharkey, Kristin A. Long
Summary: Although providing sibling psychosocial services is a standard of care in pediatric oncology, the current practices at pediatric cancer centers in the United States do not align with established care recommendations. Sibling-focused psychoeducation, screening, assessment, and support are variable between and within centers, and siblings themselves are often not involved in their own psychosocial care. There is a need for tools and strategies to improve the provision of sibling psychosocial care and to support siblings' psychosocial functioning.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Oncology
Adam J. Esbenshade, Lu Lu, Debra L. Friedman, Kevin C. Oeffinger, Gregory T. Armstrong, Kevin R. Krull, Joseph P. Neglia, Wendy M. Leisenring, Rebecca Howell, Robyn Partin, Amy Sketch, Leslie L. Robison, Kirsten K. Ness
Summary: Using a geriatric rating scale, researchers found that childhood cancer survivors accumulate diseases at a faster rate compared to their siblings and the general population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
James E. Bates, Suman Shrestha, Qi Liu, Susan A. Smith, Daniel A. Mulrooney, Wendy Leisenring, Todd Gibson, Leslie L. Robison, Eric J. Chow, Kevin C. Oeffinger, Gregory T. Armstrong, Louis S. Constine, Bradford S. Hoppe, Choonsik Lee, Yutaka Yasui, Rebecca M. Howell
Summary: Radiation-associated cardiac disease is a major concern for childhood cancer survivors, with potential risks to cardiac substructures from radiotherapy. There may be no threshold dose below which radiation to the cardiac substructures does not increase the risk of cardiac diseases, highlighting the need for careful treatment planning.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Hematology
Julian Lindsay, Carla S. Walti, Anna B. Halpern, Hu Xie, E. Lisa Chung, Kelda G. Schonhoff, Emily M. Huebner, Guang-Shing Cheng, Louise E. Kimball, Wendy M. Leisenring, Matthew Greenwood, Sharon C. -A. Chen, David C. M. Kong, Monica A. Slavin, Michael Boeckh, David N. Fredricks, Catherine Liu, Steven A. Pergam, Roland B. Walter, Joshua A. Hill
Article
Oncology
Fabien N. Belle, Christina Schindera, Marc Ansari, Gregory T. Armstrong, Maja Beck-Popovic, Rebecca Howell, Wendy M. Leisenring, Lillian R. Meacham, Jochen Rossler, Ben D. Spycher, Emily Tonorezos, Nicolas X. von der Weid, Yutaka Yasui, Kevin C. Oeffinger, Claudia E. Kuehni
Summary: The study compared the prevalence of overweight and obesity among childhood acute lymphoblastic leukemia survivors in North America and Switzerland, finding that survivors in North America had significantly higher rates of overweight and obesity compared to Swiss survivors and siblings. Risk factors for obesity among survivors included living in North America, being male, older age, non-Hispanic Black ethnicity, and younger age at diagnosis.
Article
Medicine, Research & Experimental
Danielle R. Hatchimonji, Melissa A. Alderfer, Erin L. Riegel, Robert E. Akins
Summary: The Institutional Development Award (IDeA) programs aim to enhance research infrastructure in regions with limited access to NIH funding. The Mentored Research Development Award (MRDA) is a professional development program embedded in an IDeA-funded center, providing mentorship and support to junior investigators in writing grant applications. The evaluation of outcomes from the first eight years showed that a significant number of MRDA recipients went on to receive NIH funding, highlighting the efficacy of just-in-time grant-writing support in promoting early career clinician-scientists in IDeA state contexts.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Oncology
Christina M. Amaro, Melissa A. Alderfer, Cynthia A. Gerhardt, Sarah E. Wawrzynski, Melanie Goldish, Kristin A. Long
Summary: This paper presents a transdisciplinary team science framework, using the Sibling Partnership for Advocacy, Research, and Care in Childhood Cancer (SPARCCC) as an example, to support siblings of youth with cancer. Through collaboration, the team successfully advanced advocacy, research, and support for siblings and generated novel solutions.
JOURNAL OF PEDIATRIC HEMATOLOGY-ONCOLOGY NURSING
(2023)