Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 211, Issue 2, Pages 160-168Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2012.06.010
Keywords
Anorexia nervosa; Bulimia nervosa; Positron emission tomography; Dopamine; Serotonin; Harm avoidance
Categories
Funding
- National Institute of Mental Health [MH046001, MH04298, K05-MH01894, T32-MH18399]
- Price Foundation
- Erwin-Schrodinger Research Fellowship of the Austrian Science Fund [J2188, J2359-B02]
- Austrian Science Fund (FWF) [J2188] Funding Source: Austrian Science Fund (FWF)
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Individuals with anorexia nervosa (AN) and bulimia nervosa (BN) have alterations of measures of serotonin (5-HT) and dopamine (DA) function, which persist after long-term recovery and are associated with elevated harm avoidance (HA), a measure of anxiety and behavioral inhibition. Based on theories that 5-HT is an aversive motivational system that may oppose a DA-related appetitive system, we explored interactions of positron emission tomography (PET) radioligand measures that reflect portions of these systems. Twenty-seven individuals recovered (REC) from eating disorders (EDs) (7 AN-BN, 11 AN, 9 BN) and nine control women (CW) were analyzed for correlations between [C-11]McN5652 and [C-11]raclopride binding. There was a significant positive correlation between [C-11]McN5652 binding potential (BPnon displaceable(ND)) and [C-11]Raclopride BPND for the dorsal caudate, antero-ventral striatum (AVS), middle caudate, and ventral and dorsal putamen. No significant correlations were found in CW. [C-11]Raclopride BPND, but not [C-11]McN5652 BPND, was significantly related to HA in REC EDs. A linear regression analysis showed that the interaction between [C-11]McN5652 BPND and [C-11]raclopride BPND in the dorsal putamen significantly predicted HA. This is the first study using PET and the radioligands [C-11]McN5652 and [C-11]raclopride to show a direct relationship between 5-HT transporter and striatal DA D2/D3 receptor binding in humans, supporting the possibility that 5-HT and DA interactions contribute to HA behaviors in EDs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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