Article
Neurosciences
Eliza Bliss-Moreau, Anthony C. Santistevan, Jeffrey Bennett, Gilda Moadab, David G. Amaral
Summary: The study investigates the causal role of ACC in affective responding to threat in primates. Results suggest that the primate ACC is necessary for maintaining appropriate affective responses towards potentially harmful and/or novel stimuli, and that ACC lesions can lead to a reduced reactivity towards these stimuli, with implications for mood disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Carlos Silva, Blake S. Porter, Kristin L. Hillman
Summary: Animals must continually assess effort and physiological states during tasks, with the ACC and anterior insular cortex implicated in cost-benefit decision-making. Contrary to predictions, stimulation of Cg1 did not increase persistence in the task, while stimulation of the anterior insula had little effect on effortful behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Jose Francis-Oliveira, Owen Leitzel, Minae Niwa
Summary: This article discusses the nomenclature of the medial prefrontal cortex (mPFC) subdivisions, proposing a change in the naming of the rodent cingulate cortex to anterior cingulate cortex (aCg) and mid-cingulate cortex (mCg). Based on data, the authors show evidence of distinct cortico-cortical projections from aCg and mCg to the PrL, as well as a sex difference in the aCg with males having a higher proportion of layer V neurons projecting to the PrL.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Marcos Domic-Siede, Martin Irani, Joaquin Valdes, Marcela Perrone-Bertolotti, Tomas Ossandon
Summary: The study reveals the importance of cognitive planning in human goal-directed behavior, with different brain regions playing specific roles in the planning process. Activity in the prefrontal cortex is associated with increased time needed for plan elaboration, while activity in the frontopolar cortex is negatively correlated with execution time, indicating its role in efficiency and accuracy in plan execution. Theta activity in different brain regions reflects high cognitive demand and the successful generation of self-made plans.
Article
Chemistry, Multidisciplinary
Ting Fan, Peng-Fei Guan, Xiao-Fang Zhong, Meng-Ya Xiang, Ying-Qiu Peng, Ruo-Qiao Zhou, Jia-Min Gong, Yu-Qing Zheng, A-Qiang Dai, Jia-Ling Feng, Hong-Zhe Yu, Jian Li, Hua-Wei Li, Yun-Feng Wang
Summary: Compared with individuals with hearing loss, tinnitus patients without hearing loss have more psychological or emotional problems. This study found that tinnitus is closely associated with abnormal metabolism and function in the limbic system, but the specific molecular mechanism is unknown. The anterior cingulate cortex (ACC) was identified as a key brain region involved in the onset of tinnitus in mice, and there were changes in metabolism and phosphorylation patterns in the glutamatergic synaptic pathway. Additionally, the electroencephalogram of tinnitus patients showed increased functional connectivity between the ACC and the primary auditory cortex, which was correlated with the serum glutamate level.
Review
Medicine, Research & Experimental
Yijie Zhao, Samantha N. Sallie, Hailun Cui, Ningning Zeng, Jiang Du, Tifei Yuan, Dianyou Li, Dirk De Ridder, Chencheng Zhang
Summary: This review discusses the anterior cingulate cortex (ACC) as a neuromodulation target for substance use disorder (SUD), highlighting its central role in addiction-related neural networks and potential for more precise and effective treatment approaches targeting different subregions based on patients' symptom profiles and cognitive deficits.
Article
Neurosciences
Dara G. Ghahremani, Jean-Baptiste Pochon, Maylen Perez Diaz, Rachel F. Tyndale, Andy C. Dean, Edythe D. London
Summary: This study aimed to investigate the relationship between distinct networks in the ventral and dorsal anterior insula and withdrawal symptoms after smoking cessation. Results suggest a crucial role of right ventral anterior insula-dorsal anterior cingulate cortex connectivity in maintaining internal states related to smoking behavior.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Fei Luo, Jun -yang Deng, Xuan Sun, Jian Zhen, Xiao-dan Luo
Summary: Early-life stress has long-term impacts on the structure and function of the anterior cingulate cortex (ACC) and raises the risk of adult neuropsychiatric disorders including social dysfunction. Maternal separation (MS) during the first three postnatal weeks in female mice leads to social impairment accompanied by hypo-activity in pyramidal neurons (PNs) of the ACC. Activation of ACC PNs improves MS-induced social impairment. The down-regulation of neuropeptide Hcrt, which encodes hypocretin (orexin), is observed in the ACC of MS females. Activation of ACC orexin terminals enhances the activity of ACC PNs and restores the diminished sociability in MS females through an orexin receptor 2 (OxR2)-dependent mechanism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Adriana K. Cushnie, Wei Tang, Sarah R. Heilbronner
Summary: Human neuroimaging has revealed large-scale functional networks in the cerebral cortex consisting of functionally correlated brain regions. The salience network (SN) plays a crucial role in addiction and is disrupted in individuals with addiction. Although there is growing evidence on the SN and addiction, there are still unknowns and limitations in human neuroimaging studies. Translating human functional networks to nonhuman animals provides opportunities to investigate circuit-level mechanisms and the perturbation of the SN sheds light on functional cortical networks and addiction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Xiaona Fu, Mengting Qin, Xiaoming Liu, Lan Cheng, Lan Zhang, Xinli Zhang, Yu Lei, Qidong Zhou, Peng Sun, Liangjie Lin, Ying Su, Jing Wang
Summary: This study investigated the relationship between GABA levels, cortical thickness, and executive function in MCI patients. The results showed that MCI patients had lower GABA+/Cr levels in the ACC and PCC, while there were no differences in cortical thickness between the two groups. Therefore, GABA in the ACC and PCC could be a potential diagnostic marker for the decline in executive function in MCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Giovana Benassi-Cezar, Isabela Miranda Carmona, Daniela Baptista-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza
Summary: The study found that cohabitation with a conspecific suffering from chronic pain affects the anxiety levels of mice, with changes in neuronal activation observed in the anterior cingulate and insular cortices. Injecting a synaptic blocker in these brain areas can reverse the anxiety-inducing effect caused by cohabitation with a conspecific in chronic pain.
Article
Pharmacology & Pharmacy
Yong He, Yue Wang, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong, Yi Guo, Peng Xie
Summary: Neuroinflammation is closely linked to the onset of depression. Nr4a2 protein plays a role in dopaminergic neurons and can alleviate inflammation. However, its effects on neuroinflammation associated with depression are still unclear.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Yujiao Yang, Dong Chen, Jing Wang, Jie Wang, Zhaofen Yan, Qinqin Deng, Liping Zhang, Guoming Luan, Mengyang Wang, Tianfu Li
Summary: This study aimed to investigate the dynamic coupling between the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) during seizures. The results showed that the functional connectivity and excitability between these two brain regions significantly increased at seizure onset. By analyzing the connectivity and excitability, the seizure-onset zone (SOZ) in ACC and AIC can be identified.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Norbert Hogrefe, Sigrid M. Blom, Kristina Valentinova, Niels R. Ntamati, Lotte J. E. Jonker, Natalie E. Nevian, Thomas Nevian
Summary: Malfunctioning synaptic plasticity is a major mechanism in the development of chronic pain. This study shows that even after recovery, the impact of chronic compression injury on synaptic plasticity persists.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Lilya Andrianova, Steliana Yanakieva, Gabriella Margetts-Smith, Shivali Kohli, Erica S. Brady, John P. Aggleton, Michael T. Craig
Summary: The connectivity and interplay between the prefrontal cortex and hippocampus are important for cognitive processes, but the existence of a direct glutamatergic projection from the anterior cingulate cortex to the hippocampus has been questioned. In this study, multiple methods were used to validate a recent finding of this projection, but no evidence of such a projection was found.
Letter
Psychology, Clinical
Sheilagh Hodgins, Markku Eronen, Roland Freese, Stephen Hart, Ruediger Mueller-Isberner, Deborah Ross, Christopher Webster, Jari Tiihonen
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Arto Puranen, Marjaana Koponen, Markku Lahteenvuo, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: Mood stabilizers are commonly used as adjunctive treatment in schizophrenia, and their use is associated with a decreased risk of psychosis rehospitalization.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Tapio Paljarvi, Jari Tiihonen, Markku Lahteenvuo, Antti Tanskanen, Seena Fazel, Heidi Taipale
Summary: This study used routine data from nationwide health registers in Finland to estimate the risk of cause-specific mortality in psychotic depression compared with severe non-psychotic depression while controlling for comorbid psychiatric disorders. The results showed that individuals with psychotic depression had a higher risk of all-cause mortality, suicides, and fatal accidents during the subsequent 5-year period after the index diagnosis compared with those with non-psychotic depression. Prompt treatment and enhanced monitoring for psychotic symptoms are necessary to prevent deaths because of suicides and other external causes in patients with severe depression.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Iris E. Sommer, Bodyl A. Brand, Shiral Gangadin, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: Women with schizophrenia have a higher risk of hospitalization for psychosis compared to men, especially after the age of 45. The effectiveness of antipsychotic medications also declines in women after this age. This highlights the importance of providing special attention and care to older women with schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tapio Paljarvi, Jari Tiihonen, Markku Lateenvuo, Antti Tanskanen, Seena Fazel, Heidi Taipale
Summary: This study aimed to establish the risk of suicide associated with incident psychotic depression (PD) compared to incident non-psychotic severe depression (NPD). The results showed that PD was associated with a twofold increased risk of suicide compared to NPD, with the highest relative risks for impact-related and suffocation-related suicides. This study revealed some characteristics of PD patients in terms of the severity of suicidal ideation and choice of self-harm methods.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Johan Lundberg, Thomas Cars, Sven-ake Loeoev, Jonas Soederling, Johan Sundstroem, Jari Tiihonen, Amy Leval, Anna Gannedahl, Carl Bjoerkholm, Mikael Sjaelin, Clara Hellner
Summary: This cohort study estimated the burden of treatment-resistant depression (TRD) and developed a prognostic model for clinical use. The study found that TRD is associated with a high burden for both patients and society, and the time between initiation of new antidepressant treatments is longer than recommended in current treatment guidelines.
Article
Psychiatry
Johannes Lieslehto, Jari Tiihonen, Markku Lahteenvuo, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Heidi Taipale
Summary: This study examined the comparative effectiveness of pharmacological treatments for borderline personality disorder (BPD). The results showed that antidepressants, antipsychotics, and benzodiazepines were associated with an increased risk of psychiatric rehospitalization. However, ADHD medications were associated with a reduced risk of psychiatric rehospitalization and all-cause hospitalization or death.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Heidi Taipale, Antti Tanskanen, Jari Tiihonen
Summary: This study found that antipsychotic polypharmacy is safer than monotherapy in specific dosage categories.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Jani Liimatta, Christa E. Fluck, Aino Mantyselka, Merja R. Hakkinen, Seppo Auriola, Raimo Voutilainen, Jarmo Jaaskelainen, Timo A. Lakka
Summary: A 2-year lifestyle intervention study found that physical activity and dietary interventions can attenuate the increase of sexual maturation and androgen concentrations in normal-weight children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Katja Hakkinen, Wilma Kiander, Heidi Kidron, Markku Lahteenvuo, Lea Urpa, Jonne Lintunen, Kati-Sisko Vellonen, Seppo Auriola, Minna Holm, Kaisla Lahdensuo, Olli Kampman, Erkki Isometsa, Tuula Kieseppa, Jouko Lonnqvist, Jaana Suvisaari, Jarmo Hietala, Jari Tiihonen, Aarno Palotie, Ari V. Ahola-Olli, Mikko Niemi
Summary: Six rare SLCO1B1 single nucleotide variants (SNVs) were identified in Finnish individuals with a psychotic disorder, which may affect the expression and functionality of the OATP1B1 protein. Functional studies showed that one of these SNVs (c.629G>T) resulted in the loss of OATP1B1 function and decreased membrane protein expression.
MOLECULAR PHARMACEUTICS
(2023)
Editorial Material
Endocrinology & Metabolism
Ville Koistinen, Olli Kaerkkaeinen, Pekka Keski-Rahkonen, Hiroshi Tsugawa, Augustin Scalbert, Masanori Arita, David Wishart, Kati Hanhineva
Summary: The metabolomics literature needs improved nomenclature for individual metabolites to ensure consistency and avoid misinterpretations. This Comment proposes recommendations for metabolite annotations to encourage the scientific community and publishers to adopt a more standardized approach.
Article
Biology
Aleksi Husso, Tiina Pessa-Morikawa, Ville Mikael Koistinen, Olli Karkkainen, Hyuk Nam Kwon, Leo Lahti, Antti Iivanainen, Kati Hanhineva, Mikael Niku
Summary: Maternal microbiota has a significant impact on fetal development, with gene expression differences in the fetal intestines, brains, and placenta associated with microbial metabolite concentrations. Male fetuses may be more susceptible to microbial modulation, affecting genes important for immune system, neurophysiology, translation, and energy metabolism before birth. Several microbial metabolites have been identified in this context, with many important metabolites yet to be discovered.
Article
Clinical Neurology
Jonne Lintunen, Markku Lahteenvuo, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: This study investigated the prevalence of primary non-adherence to medication and its associated factors in patients with bipolar disorder in Finland. The majority of patients did not adhere to their prescribed medications, with factors such as young age, recent diagnosis of bipolar disorder, multiple hospitalizations, and use of benzodiazepines or antidepressants being associated with an increased risk of non-adherence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Johanna Koskivuori, Raimo Voutilainen, Markus Storvik, Merja R. Hakkinen, Lauri Uusitalo, Leea Keski-Nisula, Katri Backman, Seppo Auriola, Marko Lehtonen
Summary: This study compared the concentrations of 17 steroids in newborn hair and umbilical cord serum. The results showed high individual variations in steroid hormone concentrations in both sample matrices. The concentrations of cortisol, corticosterone, estrone, estradiol, dehydroepiandrosterone, 118-hydroxyandostenedione, 5α-androstanedione, and 17α-hydroxypregnenolone were positively correlated between cord serum and newborn hair samples. In addition, cortisol and 11bOHA4 concentrations were positively correlated with each other in both sample types. Minor sex differences in steroid concentrations were observed, and parity and delivery mode were significant factors associated with certain adrenocortical steroid concentrations.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
