Review
Chemistry, Medicinal
Eduardo Bustos Mass, Gilmar Vieira Duarte, Dennis Russowsky
Summary: This review systematically summarizes the importance of Quinazoline and/or chalcones derivatives in medicinal chemistry and pharmaceutical research, highlighting the benefits and potential new biological activities that can be achieved by combining these two pharmacophores into single molecules. The increasing number of publications in this field indicates the significance of molecular hybridization in drug discovery.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Crystallography
Rong Zeng, Cong Huang, Jie Wang, Yuan Zhong, Qingwen Fang, Shuzhen Xiao, Xuliang Nie, Shangxing Chen, Dayong Peng
Summary: In this paper, four new compounds with quinazolinone structure were designed and synthesized using a one-pot method after intramolecular cyclization and dehydration catalyzed by aqueous methylamine solution. The structures of the compounds were characterized and the antifungal activity of the compounds was tested, showing significant activity against phytopathogenic fungi. Among them, compound 2c exhibited the best inhibitory effect against Fusarium oxysporum f. sp. Niveum fungus, making it a potential compound for the treatment of watermelon Fusarium wilt.
Article
Biochemistry & Molecular Biology
Vishal K. Singh, Priyanka Kumari, Anup Som, Shivangi Rai, Richa Mishra, Ramendra K. Singh
Summary: A series of new quinoline derivatives were designed, synthesized, and evaluated as antibacterial and antifungal agents. These compounds functioned as peptide deformylase enzyme (PDF) inhibitors and fungal cell wall disruptors. They exhibited excellent antibacterial activity against Bacillus cerus, Staphylococcus, Pseudomonas, and Escherichia coli, with compounds 2 and 6 showing the best activity. In addition, all compounds demonstrated potential antifungal activity against A. flavus, A. niger, F. oxysporum, and C. albicans, with compound 6 being the most potent. Compound 6 also exhibited the least toxicity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Agriculture, Multidisciplinary
Jing-Wen Peng, Xiao-Dan Yin, Hu Li, Kun-Yuan Ma, Zhi-Jun Zhang, Rui Zhou, Yu-Ling Wang, Guan-Fang Hu, Ying-Qian Liu
Summary: Novel quinazolinone derivatives were synthesized and compound 6c showed remarkable antifungal activity against various phytopathogenic fungi with significant inhibitory concentrations. Mechanism studies revealed its impact on fungal morphology and cell membranes. In vivo assays demonstrated its comparable effectiveness to a positive control, making compound 6c a promising fungicide candidate for exploring potent antifungal agents.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hoda Jamshidi, Mohammad Reza Naimi-Jamal, Maliheh Safavi, Kimia RayatSanati, Parisa Azerang, Azar Tahghighi
Summary: A series of 1,2,3-triazole-based polyaromatic compounds containing chloroquinoline moiety were synthesized using click chemistry and showed promising antimicrobial and antifungal activities.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Sajedeh Safapoor, Mohammad Halimi, Minoo Khalili Ghomi, Milad Noori, Navid Dastyafteh, Shahrzad Javanshir, Samanesadat Hosseini, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Ensieh Nasli-Esfahani, Bagher Larijani, Azadeh Fakhrioliaei, Mohammad G. Dekamin, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi
Summary: A new series of quinoline-quinazolinone-thioacetamide derivatives 9a-p were designed and synthesized. These compounds showed significant anti-a-glucosidase activity, with compound 9g being the most potent inhibitor. Molecular simulation studies revealed that compound 9g occupied the active site of a-glucosidase with favorable binding energy. In silico ADMET studies of the most potent compounds predicted their drug-likeness, pharmacokinetic, and toxicity properties.
Article
Biochemistry & Molecular Biology
Huan Du, Muhan Ding, Na Luo, Jun Shi, Jian Huang, Xiaoping Bao
Summary: A series of novel compounds were synthesized and evaluated for their in vitro antibacterial and antifungal activities in agriculture. Some compounds displayed notable bactericidal potencies against plant pathogenic bacteria, suggesting potential applications in agriculture.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Applied
Matthew S. Lish, Jillian E. Milanes, Kyana M. Sanders, Ilia A. Guzei, James C. Morris, Jennifer E. Golden
Summary: A three-step synthesis of anti-amoebic, ring-fused mackinazolinones has been developed. The methodology involves a Mannich-type reaction followed by a domino rearrangement to afford 45 separable, ring-fused products. Several compounds derived from this synthesis showed inhibition of Naegleria fowleri parasites. This approach provides immediate access to a promising anti-amoebic scaffold.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Fatma M. Thabet, Kamal M. Dawood, Eman A. Ragab, Mohamed S. Nafie, Ashraf A. Abbas
Summary: A series of new compounds were synthesized and evaluated for their cytotoxicity and apoptosis-inducing ability. Among them, compound 8i showed promising anti-breast cancer activity and potential for drug development.
Article
Biochemistry & Molecular Biology
Shekh Sabir, Theerthankar Das, Rajesh Kuppusamy, Tsz Tin Yu, Mark D. P. Willcox, David StC Black, Naresh Kumar
Summary: In this study, a series of novel quinazolinone disulfide-containing competitive inhibitors of PqsR were designed and synthesized. The most potent analogue, 8q, effectively inhibited the pqs system, leading to suppression of pyocyanin production and reduction in biofilm formation by P. aeruginosa. The compound also showed synergy when used in combination with known antibiotics.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eman M. Fathalla, Mezna Saleh Altowyan, Joerg H. Albering, Assem Barakat, Morsy A. M. Abu-Youssef, Saied M. Soliman, Ahmed M. A. Badr
Summary: The synthesis and characterization of the quinazolinone-nitrate (4HQZN) complex were investigated in this study. The crystal structure and supramolecular structure of 4HQZN were determined, and the impact of medium effects on its stability and structure was explored. Furthermore, the antioxidant, anticancer, and antimicrobial activities of 4HQZN were evaluated and compared with those of 4HQZ.
Article
Chemistry, Medicinal
Subhasis Dey, Anjali Patel, Nandan Haloi, Soumya Srimayee, Suman Paul, Ganesh Kumar Barik, Nasim Akhtar, Dipanjan Shaw, Gunanka Hazarika, Biswa Mohan Prusty, Mohit Kumar, Manas Kumar Santra, Emad Tajkhorshid, Surajit Bhattacharjee, Debasis Manna
Summary: This study reports the development of a new 8-aminoquinoline derivative with promising antibacterial activity against Gram-positive bacteria, reduced hemolytic activity and cytotoxicity to mammalian cells. In addition, the combination of this derivative showed excellent efficacy against Staphylococcus aureus and restored the susceptibility of other antibiotics against drug-resistant bacterial strains. The findings suggest that transmembrane zinc ion transport by the derivative could be a promising strategy for combating bacterial infections and restoring antibiotic activity.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Hany M. Abd El-Lateef, Mai M. Khalaf, Mahmoud Kandeel, Amer A. Amer, Antar A. Abdelhamid, Aly Abdou
Summary: The main purpose of this study is to design and synthesize new Co(II), Ni(II), and Cu(II) mixed-ligand complexes derived from an easily synthesized azo-ligand, [2-(phenylthio)phenyl]diazenyl}-2-naphthol (HTe), with 8-hydroxyquinoline (HQ) for antimicrobial activity evaluation. The complexes were characterized and their molecular structures were optimized using DFT calculations. The disc diffusion test showed that the prepared complexes exhibited higher antibacterial activity compared to the pristine ligands. Molecular docking studies revealed potential antibiotic properties of these complexes. The correlation between in vitro activity and DFT/molecular docking data was discussed.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Mohammed A. I. Elbastawesy, Fatma A. M. Mohamed, Islam Zaki, Mohammed Issa Alahmdi, Seham S. Alzahrani, Hayat Ali Alzahrani, Hesham A. M. Gomaa, Bahaa G. M. Youssif
Summary: A new series of quinoline-2-one Schiff-base hybrids were synthesized and characterized. The compounds were screened for antimicrobial activity and compound 6c showed significant inhibitory effects against B. subtilis, E. coli, and S. aureus. It also exhibited inhibitory activity against E. coli topoisomerase IV and DNA gyrase.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Medicinal
Zhenghua Li, Li Zhao, Yunqiang Bian, Yu Li, Jie Qu, Feng Song
Summary: This review highlights the antibacterial potential, structure-activity relationships (SARs), and mechanism of action of quinazoline and quinazolinone hybrids, providing valuable insights for the development of novel antibacterials.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Asha V. Chate, Sagar P. Kamdi, Amruta N. Bhagat, Jaiprakash N. Sangshetti, Charansingh H. Gill
SYNTHETIC COMMUNICATIONS
(2018)
Article
Chemistry, Organic
Amol S. Nipate, Chetan K. Jadhav, Asha Chate, Kanchan S. Taur, Charansingh H. Gill
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Asha V. Chate, Ankita S. Kulkarni, Chetan K. Jadhav, Amol S. Nipte, Girabala M. Bondle
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Chetan K. Jadhav, Amol S. Nipate, Asha Chate, Vishal D. Songire, Anil P. Patil, Charansingh H. Gill
Article
Chemistry, Organic
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Anil P. Patil, Charansingh. H. Gill
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Pratiksha M. Kamble, Ganesh A. Kadam, Vidya S. Dofe, Vijay M. Khedkar, Charansingh H. Gill
Summary: This study utilized an ionic liquid as a catalyst and green solvent for efficient synthesis of tetra- and trisubstituted imidazole scaffolds, resulting in high yields and purity of products. The advantage of this method in gram-scale synthesis and the potent cytotoxic activity of selected compounds against human cancer cell lines were highlighted.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Charansingh. H. Gill
Summary: An innovative method for the synthesis of 2-amino-4H-pyranoquinolines has been developed, utilizing beta-cyclodextrin as a reusable supramolecular catalyst in a one-pot three-component reaction catalyzed under ultrasound irradiation in an aqueous medium. The tandem process allows for efficient and convenient synthesis of target products meeting pharmaceutical chemistry requirements.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Amol S. Nipate, Chetan K. Jadhav, Asha Chate, Tejshri R. Deshmukh, Aniket P. Sarkate, Charansingh H. Gill
Summary: In this study, a new series of compounds were synthesized using click chemistry approach and analyzed using various spectroscopic techniques. The cytotoxicity assay revealed that compound 5b exhibited the most potent anticancer activity, while compounds 5a and 5q also showed significant anticancer effects compared to the reference drug Adriamycin.
Article
Chemistry, Multidisciplinary
Chetan Jadhav, Amol Nipate, Asha Chate, Charansingh Gill
Summary: An operationally simple method for the assembly of pyrido[2,3-d]pyrimidine and pyrazolo[3,4-b]pyridine derivatives has been developed, achieving excellent yields and high purity. The study found that using 1 mmol of the ionic liquid catalyst under solvent-free conditions at 60 degrees Celsius is the optimal reaction parameter for constructing fused pyridine and pyrimidine derivatives. The methodology showed promising results under gram-scale conditions, suggesting potential applicability in both industrial and academic settings in the future.
Article
Chemistry, Organic
Chetan K. Jadhav, Amol S. Nipate, Asha Chate, Makrand Kulkarni, Vidya S. Dofe, Charansingh H. Gill
Summary: An efficient one-pot multicomponent synthesis of 3-amino-1-alkylpyridin-2(1H)-ones using 1,8-diazabicyclo [5,4,0] undec-7-enium acetate [DBUH][OAc] ionic liquid as a green solvent medium was achieved with mild conditions and outstanding conversion rates. The recyclability and recovery of the ionic liquid make this protocol environmentally desirable, and the synthesized compounds showed promising in vitro antitumor activity against human cancer cell lines.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Charansingh H. Gill
Summary: A simple and effective protocol for synthesizing dihydropyrido[2,3-d]pyrimidine derivatives using 2-aminoethanesulfonic acid in water was presented. This method produced uracil annulated heterocycles with good to excellent yields, offering operational simplicity, easy workup, superior green credentials, and the ability to reuse the catalyst multiple times without significant loss in activity.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Chetan K. Jadhav, Amol S. Nipate, Asha Chate, Makrand Kulkarni, Charansingh H. Gill
Summary: In this study, bioactive compounds were successfully synthesized using task-specific ionic liquids as catalysts. The method offers mild reaction conditions, high recyclability, and environmental friendliness.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Makrand Kulkarni, Chetan K. Jadhav, Amol S. Nipate, Sarita Bhutada, Charansingh H. Gill, Bhausaheb K. Magar
Summary: A green synthesis method has been developed to efficiently access pharmaceutically relevant functionalized coumarin-pyrazole molecular hybrids. This new procedure offers high yields, short reaction times, simple experimental and work-up procedures, mild reaction conditions and environmental friendliness, along with an economically available catalyst.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Amol S. Nipate, Chetan K. Jadhav, Asha V. Chate, Prashant P. Dixit, Prachi Sharma, Charansingh H. Gill
Summary: A series of fluorine-containing quinoline analogues, known as hybrid Schiff bases (6a-o), were successfully synthesized through a facile and efficient conventional method. These compounds were developed via the condensation of a quinoline-4-carbohydrazide intermediate and aromatic aldehydes using ethanol as a solvent. All synthesized compounds (6a-o) exhibited good yields ranging from 76% to 84%. The synthesized compounds were comprehensively characterized using various spectroscopic techniques, including FT-IR, H-1 NMR, C-13 NMR, and Mass spectroscopy. Additionally, the antifungal and antibacterial activity of the newly synthesized hybrid Schiff bases (6a-o) were evaluated. Compounds 6a-d showed promising antibacterial activity, while compound 6b exhibited effectiveness against the fungal pathogen Aspergillus niger. Compound 6a was found to inhibit the visible growth of Staphylococcus aureus ATCC 6538 at a low concentration with a minimum inhibitory concentration of 340 μg/.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Chetan K. Jadhav, Amol S. Nipate, Asha Chate, Vidya S. Dofe, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Charansingh H. Gill
Article
Chemistry, Multidisciplinary
Wafa A. Bawazir, Maymoona A. Al-Mahmood, Rawan S. Almalki, Ghadi F. Alofi, Raghad S. Alharbi, Zoya Zaheer
Summary: This study investigates the interaction between sulfathiazole and three types of surfactants using UV-visible spectroscopy and conductivity measurements. The results show that the critical micelle concentration of cationic and anionic surfactants decreases with increasing sulfathiazole concentration, while the interaction with non-ionic surfactant is weak.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Musaad K. Aleid, Khalid N. Alharbi, Mona A. Aljufareen, Areej S. Aloliwi, Alhanouf K. Almutairi, Rahaf S. Alsaif, Nada K. Alshayeb, Mohammed S. Almoiqli
Summary: This study assessed the levels of trihalomethane compounds in the water network of Riyadh city and identified the factors influencing their formation. The concentrations of trihalomethane compounds were within the permissible limits, indicating the water's safety for human consumption. The presence of bromide ions, organic carbon, free chlorine, and pH values were found to affect trihalomethane formation.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Uyen-Chi Nguyen Le, Ngoc Xuan Dat Mai, Kieu-Minh Le, Hoang Anh Vu, Huynh-Nhu Thi Tran, Tan Le Hoang Doan
Summary: This study aimed to enhance the bioavailability of rosmarinic acid, a bioactive compound with high anticancer activity, by encapsulating it in tetrasulfide-based porous organosilica nanoparticles. The synthesized nanoparticles were small in size and had a high surface area and an average pore diameter. The nanoparticles showed effective accumulation in cancer cells without toxicity to normal cells. Treatment with rosmarinic acid-containing nanoparticles resulted in significant cell death in cancer cells. Overall, these findings suggest that the synthesized nanoparticles can enhance the pharmacological effects of rosmarinic acid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jiamin Qi, Hengxi Zhu, Tianyu Yang, Xingyuan Wang, Zixuan Wang, Xiaoli Lei, Bin Li, Wenmin Qian
Summary: This study synthesized a novel iron-biochar adsorbent using the iron content in red mud to remove heavy metals from wastewater. The adsorbent showed excellent removal efficiency and sustainability. This method addresses both industrial waste recovery and heavy metal adsorption issues.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Bo Yi, Li Zhang, Haiyang Zhou
Summary: Plasma protein binding plays a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic bioactive materials. In this study, the interaction of nordentatin, a member of coumarins, with human alpha-1 acid glycoprotein (AGP) was investigated, and the anticancer potency of nordentatin against human colorectal cancer cells was evaluated. The results showed that nordentatin binds to AGP through a static quenching mechanism and exhibits inhibitory effects on the growth of HCT-116 cells by increasing intracellular ROS and [Ca2+] levels and triggering apoptosis-related gene overexpression. Therefore, nordentatin could be a promising plant-based therapy for colorectal cancer.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T. H. Wu, Hsu-Shan Huang
Summary: Tetraheterocyclic compounds derived from natural sources and contemporary pharmaceuticals have shown promise as multitarget therapeutic agents. In this study, a series of synthesized compounds were evaluated for their potential in breast cancer treatment. Compounds 18 and 20 demonstrated significant antiproliferative activity against breast cancer cell lines and their mode of action was revealed through molecular docking simulations.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Mohammad Khosravani, Mohsen Dehghani Ghanatghestani, Farid Moeinpour, Hossein Parvaresh
Summary: The aim of removing Pb(II) from water is to minimize the potential harm posed by toxic metals to both human health and the environment. A covalent organic framework adsorbent called TFPOTDB-SO3H was developed with excellent properties such as high repeatability, selectivity, and easy solid-liquid separation. The adsorbent showed impressive capability of adsorbing Pb(II) and effective removal of it from a solution with various ions, suggesting its potential for effectively adsorbing and removing Pb(II) heavy metal ions from wastewater.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, Ragab A. Elsad
Summary: The current study examines the dielectric and thermal properties of transformer oil incorporated with Mn0.5 Zn0.5 Fe2O4 nanoparticles. The results show that the addition of Mn-Zn ferrite NPs improves the dielectric constant, dissipation factor, AC breakdown voltage, and convective heat transfer of the nanofluid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Limin Hou, Zongpei Jiang, Minqi Ye, Xueyan Sun, Kexin Liu, Yifan Zhu, Xiaoyu Wang, Liangzhu Chen, Ruiheng Gu, Binghu Fang
Summary: The excessive accumulation of antibiotic residue in animal-derived foods poses a threat to health. Therefore, it is necessary to establish a rapid, simple, effective, safe, and highly sensitive method for detecting lincomycin residues. By using a pre-column derivatization method on high-performance liquid chromatography equipped with ultraviolet, the UV absorption of lincomycin is improved, allowing for detection and quantification.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Kun Tang, Xin-Xin Wang, Jin-Jin Zhao, Ning Ren, Jian-Jun Zhang
Summary: This study reports the synthesis, crystal structures, and thermal degradation properties of three new rare earth coordination compounds. Compounds 1-3 exhibit binuclear structures which can form chain-like structures via hydrogen bonding. Compound 2 shows potential application value in the orange-red luminescence region.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Seoyoun Yang, Eunbi Yu, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: This study investigated the effects of blue light on the hypodermis and found that it has antiadipogenic properties by reducing lipid accumulation and downregulating the expression of adipogenic genes. Blue light also increased the phosphorylation of PPAR gamma and TRPV1, suggesting its anti-adipogenic effect through these signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Abdul Nasir, Abdul Waheed Khan, Hamid Rafiq Khattak, Abdus Samad, Sami Ullah, Haroon Khan, Muhammad Faheem, Qian Bai
Summary: This study evaluated the effects of isoxazolone derivatives on cisplatin-induced neuropathy in a rat model. The results showed that isoxazolone derivatives effectively reversed mechanical allodynia, similar to the known therapeutic agent pregabalin. Molecular docking analysis indicated that isoxazolone derivatives have strong binding affinity for relevant receptors and potential inhibitory activity against relevant signaling pathways. This study has innovative implications for the treatment of cisplatin-induced neuropathic pain.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Shahid Wahab, Haroon Muhammad Ali, Maham Khan, Tariq Khan, Chandran Krishnaraj, Soon-Il Yun
Summary: In this study, we synthesized chitosan nanoparticles, silver nanoparticles, and chitosan/silver nanocomposites using aqueous ginger extract as a green approach. These nanomaterials showed significant antibacterial properties and low toxicity. Furthermore, the nanomaterials conjugated with tobramycin demonstrated enhanced antibacterial efficacy and exhibited interactions with Pseudomonas aeruginosa.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
