Article
Psychiatry
Sofi da Cunha-Bang, Vibe G. Frokjaer, Brenda Mc Mahon, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudsen
Summary: This study investigated the association between brain serotonin transporter (SERT) levels and trait impulsive aggression. The results showed no significant association between SERT binding and trait impulsive aggression. Therefore, this study does not support the involvement of SERT in mediating serotonergic effects on aggression and impulsivity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jeong-Hee Kim, Hang-Keun Kim, Young-Don Son, Jong-Hoon Kim
Summary: This study explored the relationship between 5-HT2A receptor availability and aggression traits in healthy individuals, and found significant positive correlations between 5-HT2A receptor availability and overall aggression score as well as scores on different aggression subscales in multiple brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiyan Wang, Yaping Wu, Zhenxing Huang, Zhicheng Li, Na Zhang, Fangfang Fu, Nan Meng, Haining Wang, Yun Zhou, Yongfeng Yang, Xin Liu, Dong Liang, Hairong Zheng, Greta S. P. Mok, Meiyun Wang, Zhanli Hu
Summary: Our proposed deep learning method can synthesize highly correlated and consistent dynamic parametric images obtained from static lung PET. The image quality of the synthesized images was evaluated qualitatively and quantitatively, and statistical analysis of correlation and consistency was performed on the synthetic images.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qianrui Li, Wenxiu Hou, Mei Wu, Ling Li, Minggang Su, Bin Ma, Futao Cui, Yan Ren, Jiayue Xu, Kang Zou, Rong Tian, Xin Sun
Summary: This study systematically appraised the methodologies used for PET imaging guidelines and compared the consistency of these recommendations. The findings showed that current guidelines for PET imaging vary in methodological quality and provided considerably inconsistent recommendations. Efforts are needed to improve adherence to guideline development methodologies, to synthesize high-quality evidence, and to adopt standard terminologies.
EUROPEAN RADIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Giordana Salvi de Souza, Dimitri B. A. Mantovani, Pascalle Mossel, Bartholomeus C. M. Haarman, Ana Maria Marques da Silva, Hendrikus H. Boersma, Cristiane R. G. Furini, Adriaan A. Lammertsma, Charalampos Tsoumpas, Gert Luurtsema
Summary: The oral route is widely used and preferred for drug administration. Accurate quantification of drug absorption, distribution, metabolism, excretion, and characterization is crucial for drug development. In vivo methods such as gamma-scintigraphy, MRI, and PET have been used to analyze gastrointestinal absorption. This review focuses on PET studies using oral tracers, revealing variations in acquisition protocols, quantification methods, and pharmacokinetic parameters. Human studies showed 10-30 minutes for tracer to reach the intestine and about 100 minutes to reach peak concentration in the brain. Rodent studies estimated different pharmacokinetic parameters, indicating PET's potential for non-invasive measurement of drug absorption and distribution. Long Axial Field of View (LAFOV) PET scanners can reduce administered dose, making oral administration feasible for clinical studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Endocrinology & Metabolism
Louise M. Jorgensen, Tove Henriksen, Skirmante Mardosiene, Sune H. Keller, Dea S. Stenbaek, Hanne D. Hansen, Bo Jespersen, Carsten Thomsen, Pia Weikop, Claus Svarer, Gitte M. Knudsen
Summary: This study demonstrates that DBS-STN dynamically regulates the serotonin system in PD, and the preservation of serotonin function may predict the effects of DBS-STN.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Review
Crystallography
Xin Yu, Xi Zhang, Heng Zhang, Hao Peng, Qiushi Ren, Jianfeng Xu, Qiyu Peng, Siwei Xie
Summary: Positron emission tomography (PET) is widely used for the diagnosis of tumors, cardiovascular diseases, and neurological diseases. This article introduces the principle and requirements of scintillation crystals in PET and analyzes the performance of different crystals. LYSO is currently the best-performing crystal, while LaBr3 has better timing characteristics and light output. GAGG detectors have a high depth of interaction resolution and great potential for applications.
Article
Biochemical Research Methods
Palak Wadhwa, Kris Thielemans, Nikos Efthimiou, Kristen Wangerin, Nicholas Keat, Elise Emond, Timothy Deller, Ottavia Bertolli, Daniel Deidda, Gaspar Delso, Michel Tohme, Floris Jansen, Roger N. Gunn, William Hallett, Charalampos Tsoumpas
Summary: This research demonstrates successful computational and physical modelling of the PET-MR system for image acquisition, generating images comparable to those from the manufacturer; the new software developments will be integrated into STIR, providing researchers worldwide with opportunities to establish and expand their image reconstruction methods; by modelling all effects within the system matrix, PET images showing the metabolic uptake of administered radiopharmaceuticals were reconstructed accurately.
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Ming Chen, Mingchih Chen, Jeng-Guan Hsu, Tian-Shyug Lee, Ben-Chang Shia, Szu-Yuan Wu
Summary: The use of preoperative PET/CT is associated with a lower risk of death in patients with resectable stage IIIA-IIIB non-small cell lung cancer, but it does not improve survival rates in patients with stage I-II cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong Du, Jennifer M. Coughlin, Alireza Amindarolzarbi, Shannon Eileen Sweeney, Courtney K. Harrington, Mary Katherine Brosnan, Adeline Zandi, Laura K. Shinehouse, Alejandra N. Reyes Sanchez, Rehab Abdallah, Daniel P. Holt, Hong Fan, Wojciech G. Lesniak, Ayon Nandi, Steven P. Rowe, Lilja B. Solnes, Robert F. Dannals, Andrew G. Horti, Martin A. Lodge, Martin G. Pomper
Summary: This study reported the test-retest repeatability of [F-18]FNDP brain PET binding and [F-18]FNDP whole-body dosimetry in healthy individuals. The results showed that [F-18]FNDP brain PET imaging and whole-body dosimetry had favorable repeatability in healthy individuals.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Ken Kudura, Florentia Dimitriou, Daniela Mihic-Probst, Urs J. Muehlematter, Tim Kutzker, Lucas Basler, Robert Forster, Reinhard Dummer, Joanna Mangana, Lars Husmann, Irene A. Burger, Michael Christoph Kreissl
Summary: The use of FDG-PET/CT in metastatic melanoma patients has increased significantly due to improved survival rates. Indeterminate findings on FDG-PET/CT in these patients should be further investigated, as almost half of them are malignant with the majority being melanoma metastases. Other primary malignancies are also found in a significant proportion of cases, impacting clinical management in the majority of malignant findings.
Article
Gerontology
Andreas M. Appel, Henrik Bronnum-Hansen, Anne H. Garde, Ase Marie Hansen, Kazi Ishtiak-Ahmed, Sabrina Islamoska, Erik L. Mortensen, Kirsten Nabe-Nielsen
Summary: The study found that lower educational attainment and occupation-based SEP were associated with a higher risk of dementia, and higher occupation-based SEP partially mitigated the risk of dementia associated with lower education. Only unskilled work was associated with a higher risk of dementia in a subgroup of men after adjusting for cognitive ability.
JOURNAL OF AGING AND HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Marie Gronkjaer, Cathrine Lawaetz Wimmelmann, Erik Lykke Mortensen, Trine Flensborg-Madsen
Summary: This study aimed to examine the association between alcohol consumption and psychological well-being in middle-aged men and women. The findings suggest that alcohol abstinence is prospectively associated with adverse psychological well-being, while heavy alcohol consumption is also associated with adverse satisfaction with life in men. Additionally, a prospective association between weekly binge drinking and lower life satisfaction was observed in men.
Article
Psychiatry
Lea Arregui Nordahl Christoffersen, Erik Lykke Mortensen, Holger Jelling Sorensen, Ulrik Becker, Merete Osler, Trine Flensborg-Madsen
Summary: The study found that the average treatment delay for AUD was 6.9 years, and cognitive factors may affect treatment delay more than non-cognitive personal factors. Men with estimated age at onset of alcohol problems at age 20 years or younger had a 5.30 years longer treatment delay than men who had estimated age at onset of alcohol problems at age 51 years or older.
NORDIC JOURNAL OF PSYCHIATRY
(2022)
Article
Urology & Nephrology
Sophia Weber, Vibe Gedsoe Frokjaer, Sophia Armand, Julie Helmer Nielsen, Gitte Moos Knudsen, Martin Balslev Joergensen, Dea Siggaard Stenbaek, Annamaria Giraldi
Summary: Sexual dysfunction is closely associated with major depressive disorder (MDD), and treatment with selective serotonin reuptake inhibitors (SSRIs) may worsen sexual dysfunction. However, this study found that sexual function improved during treatment and was linked to the improvement of depressive symptoms.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Neurosciences
Christelle Langley, Sophia Armand, Qiang Luo, George Savulich, Tina Segerberg, Anna Sondergaard, Elisabeth B. Pedersen, Nanna Svart, Oliver Overgaard-Hansen, Annette Johansen, Camilla Borgsted, Rudolf N. Cardinal, Trevor W. Robbins, Dea S. Stenbaek, Gitte M. Knudsen, Barbara J. Sahakian
Summary: This study aimed to investigate the chronic effects of the SSRI escitalopram on cognition in healthy volunteers. The findings revealed that escitalopram decreased reinforcement sensitivity but had no significant impact on "cold" cognition and decision-making ability. These findings suggest that serotonin reuptake inhibition plays a role in reinforcement learning in healthy individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Psychology, Multidisciplinary
Maria Beckman, Stig Poulsen, Manoj Doss, Dea Siggaard Stenbaek
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Obstetrics & Gynecology
Agnes K. Ladelund, Julie A. Slavensky, Frederik J. Bruun, Emilie Pi Fogtmann Sejer, Erik Lykke Mortensen, Steen Ladelund, Ulrik S. Kesmodel
Summary: Birth by elective cesarean section (CS) is suggested to reduce the risk of birth-related infant mortality and injury, but it may increase the risk of somatic immune-related diseases. This study investigates the association between CS delivery and school performance and intelligence among youth.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Editorial Material
Medicine, General & Internal
Florence Butlen-Ducuing, Drummond E-Wen McCulloch, Marion Haberkamp, Taina Mattila, Ewa Balkowiec-Iskra, Georgios Aislaitner, Pavel Balabanov, Johan Lundberg, Dea Siggaard Stenbaek, Andre Elferink, Gitte M. Knudsen, Steffen Thirstrup
Article
Psychiatry
Kristin Koehler-Forsberg, Vibeke H. Dam, Brice Ozenne, Anjali Sankar, Vincent Beliveau, Elizabeth B. Landman, Soren V. Larsen, Asbjorn S. Poulsen, Cheng-Teng Ip, Anders Jorgensen, Michal Meyer, Dea S. Stenbaek, Hans R. L. Eiberg, Jacob Madsen, Claus Svarer, Martin B. Jorgensen, Vibe G. Frokjaer, Gitte M. Knudsen
Summary: This study found that patients with major depressive disorder (MDD) have lower cerebral 5-HT4 receptor binding compared to healthy controls, and memory dysfunction in MDD patients is associated with lower cerebral 5-HT4 receptor binding. This suggests that the cerebral 5-HT4 receptor may be a promising treatment target for memory dysfunction in patients with MDD.
Article
Endocrinology & Metabolism
Daniel Radbro Burmester, Martin Korsbak Madsen, Attila Szabo, Sagar Sanjay Aripaka, Dea Siggaard Stenbaek, Vibe G. Frokjaer, Betina Elfving, Jens D. Mikkelsen, Gitte Moos Knudsen, Patrick MacDonald Fisher
Summary: This study investigated the effect of a single dose of psilocybin on biomarkers of inflammation in healthy individuals. The results showed that psilocybin did not significantly reduce the concentrations of inflammation biomarkers. The study suggested that future research should consider additional markers of inflammation, including neuroinflammation markers, and evaluate the potential anti-inflammatory effects of psilocybin therapy in clinical populations.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Engineering, Marine
Angelos Ikonomakis, Klaus Kahler Holst, Ulrik Dam Nielsen
Summary: In vessel performance analysis, reliable speed-through-water (STW) information is crucial for accurate modeling of a single ship's fuel efficiency. This paper presents a study that uses three variations of a Dynamic Factor Model to estimate the STW. Simulation and real vessel data are used to validate the model's performance in minimizing systematic STW measurement error, even under non-stationary conditions.
Article
Psychiatry
Annika Laebo Rasmussen, Soren Vinther Larsen, Brice Ozenne, Kristin Kohler-Forsberg, Dea Siggaard Stenbaek, Martin Balslev Jorgensen, Annamaria Giraldi, Vibe G. Frokjaer
Summary: Sexual dysfunction is common in depression, especially in women. Lower brain levels of the 5-HT4 receptor in patients with depression may be related to reduced sexual desire. This study aims to investigate the neurobiology of sexual dysfunction in untreated patients with depression.
TRANSLATIONAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Vibe G. Frokjaer
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Trine Munk-Olsen, Arianna Di Florio, Kathrine B. Madsen, Clara Albinana, Merete L. Maegbaek, Veerle Bergink, Vibe G. Frokjaer, Esben Agerbo, Bjarni J. Vilhjalmsson, Thomas Werge, Merete Nordentoft, David M. Hougaard, Anders D. Borglum, Ole Mors, Preben Bo Mortensen, Xiaoqin Liu
Summary: Using a nested case-control study, we found that polygenic risk scores differ between postpartum depression (PPD) cases and depression with onset outside the postpartum period (MDD) cases, suggesting a potential genetic distinction. However, after accounting for selection-related reproductive behavior, there was no clear evidence of a distinct genetic makeup in women with depression occurring during or outside the postpartum period.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Juliane Conradi, Jonas E. Svensson, Soren V. Larsen, Vibe G. Frokjaer
Summary: This study did not confirm a positive association between the cortisol awakening response (CAR) and prefrontal 5-HTT BPND in an independent dataset, and there were no apparent sex differences in the association. The data do not exclude the involvement of the serotonin transporter system in regulating stress responses in at-risk or manifest depressed states.