Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 172, Issue 3, Pages 215-219Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2008.09.005
Keywords
Reading disability; Anisotropy; Superior longitudinal fasciculus
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Funding
- NIH [P50 HD52121, P30 HD24061, P01 HD24448]
- Charles A. Dana Foundation
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Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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