Article
Ophthalmology
Titap Yazicioglu, Rahsan Inan, Anil Agackesen, Murat Oklar, Saban Simsek
Summary: The research findings suggest that functional epiphora is caused by neurogenic damage of the orbicularis oculi muscle and requires further detailed investigation.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Larysa Krajewska-Weglewicz, Marta Banach, Ewa Filipiak, Joanna Sempinska-Szewczyk, Piotr Skopinski, Malgorzata Dorobek
Summary: This article proposes a new application for eyelid surface electromyography (sEMG) and demonstrates its feasibility in clinical practice. The study shows that sEMG can be used as a diagnostic tool in monitoring post-operative recovery of the orbicularis oculi muscle (OOM) and that sEMG parameters normalize within 6 months after surgery. Electrode placement in the mid-pretarsal area of the upper eyelid offers advantages and enhances the feasibility of sEMG.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Ruth Graf, Daniele Pace
Summary: The study followed 435 patients who underwent blepharoplasty surgery for 12 months and found high patient satisfaction and no complications. Some patients required hyaluronic acid fillers in the tear trough area 12 months after surgery.
AESTHETIC PLASTIC SURGERY
(2021)
Review
Surgery
Osama A. Samargandi, Neetin Prabhu, Colton Boudreau, Jason Williams
Summary: Comparing skin-OOM strip resection with skin only upper blepharoplasty, there was no significant difference in long-term aesthetic outcomes, but muscle strip resection was associated with higher ophthalmological morbidity initially, which resolved with conservative treatment within a few weeks.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Medicine, General & Internal
Chun-Chieh Lai, Chia-Chen Lin
Summary: This study reports three cases of successful treatment of exposure keratopathy with botulinum toxin-A after surgery. Injecting botulinum toxin-A around the central supra-brow area can effectively manage exposure keratopathy without permanently affecting the function of the FOOM flap.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Raiyyan Aftab, Pandora Bibby, Pamela White, Meenakshi Swamy, Debra Patten, Daniel B. Saleh
Summary: Facial nerve palsy can be distressing for patients, and this study investigates the viability of muscle transfer surgery to restore symmetrical blinking. The researchers found that a flap can theoretically transpose to over 50% of the contralateral eyelid length, potentially providing a solution for restoring symmetrical blinking that current paralysis surgery fails to achieve.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
Mengying Duan, Chao Yue, Jianzhong Peng
Summary: Reconstruction of lower-eyelid defects using a rotation flap pedicled by the orbicularis oculi is a good choice for single-stage reconstruction, with no observed ectropion, abnormal eyelid position, or donor-site morbidity during follow-up.
FRONTIERS IN SURGERY
(2022)
Review
Clinical Neurology
Elena Scherrer, Karla Chaloupka
Summary: Facial nerve palsy can cause eyelid closure problems, which can lead to corneal damage. Current management options include lubrication, moisture chambers, and surgery. Recent research has focused on using electrical stimulation to support muscle function. This article provides a comprehensive review of the parameters needed to achieve natural eye blinking in human subjects.
NEUROLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Joe Iwanaga, R. Shane Tubbs, Hongtae Kim, Mi-Sun Hur
Summary: The aim of this study was to investigate the relationship between the angular veins and facial muscles, and to explore the role of the facial muscles as venous valves. The findings showed that the angular veins coursed along the sites where facial muscle contractions efficiently compress the veins, indicating a possible role of the facial muscles in controlling venous flow.
Article
Health Care Sciences & Services
Lan Wang, Yanqi Wu, Min Zhu, Cuilian Zhao
Summary: This study aimed to quantify the relationship between electromyography (EMG) and force in the orbicularis oris muscle, in order to evaluate the indicators of muscle functional training and improve training effects. The results showed that using EMG signals and modeling analysis can assess muscle force and the effectiveness of functional training.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Ophthalmology
Jianhao Cai, Yuansheng Zhou, Wenjuan Lv, Wenxia Chen, Weihao Cai, Tsz Kin Ng, Zeyi Li
Summary: The study evaluates a modified technique for correcting involutional entropion through tightening the pretarsal orbicularis oculi muscle and excising excess skin of the lower eyelid. Results show that this method is effective, technically easy, with low recurrence rates and minimal complications in Asian patients.
Article
Medicine, General & Internal
Liliana Szyszka-Sommerfeld, Magdalena Sycinska-Dziarnowska, Krzysztof Wozniak, Monika Machoy, Slawomir Wilczynski, Anna Turkina, Gianrico Spagnuolo
Summary: The study found that children with Down syndrome exhibited significantly higher electrical activity in the orbicularis oris muscle during tasks such as saliva swallowing, lip compression, and phonation compared to healthy children. This suggests that children with DS may need to exert greater muscular effort to seal their lips during these functional conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Xiao Yang, Fangning Zhao, Xiaonan Yang
Summary: The study utilized shortened infrabrow excision blepharoplasty (sIBEB) combined with orbicularis oculi muscle removal, demonstrating effective correction of dermatochalasis in 40 women. Objective evaluation and subjective feedback showed high satisfaction with no complications reported.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Psychology, Biological
Carles Tapias-Espinosa, Toni Canete, Daniel Sampedro-Viana, Tomasz Brudek, Anna Kaihoj, Ignasi Oliveras, Adolf Tobena, Susana Aznar, Alberto Fernandez-Teruel
Summary: The study examined the effects of peripheral oxytocin administration on PPI in inbred and outbred rats, showing that oxytocin increased PPI in outbred rats and attenuated PPI deficits in inbred rats. The differential effects were associated with basal differences in oxytocin-mediated mechanisms in the mPFC, demonstrating potential antipsychotic-like effects of oxytocin.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Kyung Min Lim, Ahmed Abdal Dayem, Yujin Choi, Yoonjoo Lee, Jongyub An, Minchan Gil, Soobin Lee, Hee Jeong Kwak, Balachandar Vellingirl, Hyun Jin Shin, Ssang-Goo Cho
Summary: The study explored the inhibitory effect of OOM-SC-EVs isolated from waste human facial tissues obtained during ocular surgeries on melanin synthesis, as well as their potential therapeutic applications in anti-wrinkle and wound healing.
Article
Psychology, Clinical
Kirsten B. Bojesen, Bjorn H. Ebdrup, Kasper Jessen, Anne Sigvard, Karen Tangmose, Richard A. E. Edden, Henrik B. W. Larsson, Egill Rostrup, Brian V. Broberg, Birte Y. Glenthoj
PSYCHOLOGICAL MEDICINE
(2020)
Article
Psychiatry
Stefania Tognin, Hendrika H. van Hell, Kate Merritt, Inge Winter-van Rossum, Matthijs G. Bossong, Matthew J. Kempton, Gemma Modinos, Paolo Fusar-Poli, Andrea Mechelli, Paola Dazzan, Arija Maat, Lieuwe de Haan, Benedicto Crespo-Facorro, Birte Glenthoj, Stephen M. Lawrie, Colm McDonald, Oliver Gruber, Therese van Amelsvoort, Celso Arango, Tilo Kircher, Barnaby Nelson, Silvana Galderisi, Rodrigo Bressan, Jun S. Kwon, Mark Weiser, Romina Mizrahi, Gabriele Sachs, Anke Maatz, Rene Kahn, Phillip McGuire
SCHIZOPHRENIA BULLETIN
(2020)
Article
Psychiatry
C. Wenneberg, B. Y. Glenthoj, L. B. Glenthoj, B. Fagerlund, K. Krakauer, T. D. Kristensen, C. Hjorthoj, R. A. E. Edden, B. V. Broberg, K. B. Bojesen, E. Rostrup, M. Nordentoft
EUROPEAN PSYCHIATRY
(2020)
Article
Psychology, Clinical
C. Lemvigh, R. Brouwer, R. Hilker, S. Anhoj, L. Baandrup, C. Pantelis, B. Glenthoj, B. Fagerlund
Summary: Background research has shown that both genetic and environmental factors contribute to the risk of schizophrenia. This study examined twin pairs discordant for schizophrenia to identify factors that differ between patients and their unaffected co-twins. The results suggested that childhood trauma, regular cannabis use, and a polygenic risk score for schizophrenia were independent predictors of vulnerability to schizophrenia. Additionally, regular cannabis use was found to be a predictor of having a schizophrenia spectrum diagnosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Lindy Kool, Bob Oranje, Hannah Meijs, Bieke De Wilde, Jan Van Hecke, Peter Niemegeers, Jurjen J. Luykx
Summary: This study found that P3B deficits are associated with general psychopathology, while P3A and MMN deficits are associated with substance abuse and psychotic disorders respectively. Furthermore, psychopharmacological treatment had no significant impact on P3A and MMN amplitudes, but significantly affected P3B amplitude.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Developmental
Malene Foldager, Martin Vestergaard, Jonathan Lassen, Lea S. Petersen, Bob Oranje, Bodil Aggernaes, Erik Simonsen
Summary: This study examined the semantic fluency and memory for the semantics of words in children with autism spectrum disorders. The results showed that compared to typically developing controls, children with autism had reduced animal fluency, fruit typicality, and recall for fruits. These measures were associated with autistic-like symptoms and lower adaptive functioning in both the autism and control groups.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Education, Special
Jonathan Lassen, Bodil Aggernaes, Malene Foldager, Jesper Pedersen, Bob Oranje, Troels W. Kjaer, Sidse Arnfred, Martin Vestergaard
Summary: Children and adolescents with autism have psychosocial disabilities, and social communication problems have a significant impact on psychosocial functioning, requiring targeted intervention.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2022)
Article
Clinical Neurology
Karen S. Ambrosen, Fanny Fredriksson, Simon Anhoj, Nikolaj Bak, Edwin Van Dellen, Livia Dominicus, Cecilie K. Lemvigh, Mikkel E. Sorensen, Mette O. Nielsen, Kirsten B. Bojesen, Birgitte Fagerlund, Birte Y. Glenthoj, Bob Oranje, Lars K. Hansen, Bjorn H. Ebdrup
Summary: This study used data-driven machine learning based on resting-state electroencephalography to analyze functional connectivity within the Default Mode Network in antipsychotic-naive patients with first-episode schizophrenia. The patients were divided into different subtypes, and their psychopathological and cognitive profiles were examined. The results supported the existence of biological subgroups in schizophrenia and provided a feasible method for identifying early pathological patterns in this syndrome.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychology, Developmental
J. R. M. Jepsen, J. Rydkjaer, B. Fagerlund, Cecilie K. Lemvigh, A. K. Pagsberg, B. Y. Glenthoj, B. Oranje
Summary: This study explored the associations between adaptive functioning and cognition in adolescents with early-onset schizophrenia spectrum disorders (EOS). The results showed significant impairments of social- and neurocognitive functions as well as adaptive functioning in adolescents with EOS. Verbal working memory was identified as an important associate to concurrent adaptive functioning and may be a treatment target for improving cognitive and adaptive functioning in adolescents with EOS.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Psychiatry
Caitlyn Kruiper, Iris E. C. Sommer, Michiel Koster, P. Roberto Bakker, Sarah Durston, Bob Oranje
Summary: This study investigated the potential benefits of augmenting antipsychotic medication with the noradrenergic alpha 2-agonist clonidine in schizophrenia patients. The results showed that only the clonidine-treated patients experienced significant improvements in symptom severity and sensorimotor gating compared to the placebo group. These findings suggest that augmentation with clonidine could be a promising and cost-effective treatment strategy for schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
K. W. Miskowiak, H. L. Kjaestad, C. K. Lemvigh, K. S. Ambrosen, M. S. Thorvald, L. V. Kessing, B. Y. Glenthoj, B. H. Ebdrup, B. Fagerlund
Summary: This study aimed to investigate whether there are common neurocognitive subgroups in patients with schizophrenia and bipolar disorder during early stages of illness. The results showed that patients could be classified into three subgroups, including a cognitively intact subgroup, a subgroup with selective deficits, and a subgroup with global impairments. These subgroups were not related to clinical symptoms or medications, suggesting potential neurodevelopmental origins.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
L. S. Dominicus, B. Oranje, W. M. Otte, K. S. Ambrosen, S. During, F. E. Scheepers, C. J. Stam, B. Y. Glenthoj, B. H. Ebdrup, E. van Dellen
Summary: Electroencephalography can contribute to the diagnosis and treatment response prediction in patients with a first episode of psychosis (FEP). This study found no significant differences in EEG characteristics between FEP patients and healthy controls. However, these characteristics showed predictive value for positive symptom reduction following treatment with antipsychotic medication.
Article
Psychiatry
Amanda Worker, Pierre Berthert, Andrew J. Lawrence, Seyed Mostafa Kia, Celso Arango, Richard Dinga, Silvana Galderisi, Birte Glenthoj, Rene S. Kahn, Anoushka Leslie, Robin M. Murray, Carmine M. Pariante, Christos Pantelis, Mark Weiser, Inge Winter-van Rossum, Philip Mcguire, Paola Dazzan, Andre F. Marquand
Summary: This study utilized normative modeling of cortical thickness in first-episode psychosis patients to identify individualized cortical markers associated with high biological heterogeneity and deviations in cortical thickness related to the severity of negative symptoms.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neuroimaging
Sara Ambrosino, Hasnaa Elbendary, Maarten Lequin, Dominique Rijkelijkhuizen, Tobias Banaschewski, Simon Baron-Cohen, Nico Bast, Sarah Baumeister, Jan Buitelaar, Tony Charman, Daisy Crawley, Flavio Dell'Acqua, Hannah Hayward, Rosemary Holt, Carolin Moessnang, Antonio M. Persico, Roberto Sacco, Antonia San Jose Caceres, Julian Tillmann, Eva Loth, Christine Ecker, Bob Oranje, Declan Murphy, Sarah Durston
Summary: This study systematically assessed neuroradiological findings in a large cohort of individuals with Autism Spectrum Disorder (ASD) and found a higher incidence of such findings compared to controls. Certain abnormalities were more common in ASD, which may provide insights into the neurodevelopmental mechanisms involved. Clinical MRI assessments could be valuable in guiding further investigations and research on ASD.
NEUROIMAGE-CLINICAL
(2022)
