Article
Clinical Neurology
Shen Li, Bin Yu, Dongmei Wang, Luyao Xia, Li Wang, Dachun Chen, Meihong Xiu, Xiang Yang Zhang
Summary: This study found that SG-P50 deficit may be an informational biomarker for depressive symptoms and neurocognitive impairments in FEAN-SCZ patients. For depressive FEAN-SCZ patients, the S2 amplitude of SG-P50 may serve as an independent predictor of MCCB-Mazes (NAB).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Engineering, Biomedical
Qi Chang, Cancheng Li, Jicong Zhang, Chuanyue Wang
Summary: This study discovered and characterized P50 dynamic brain connections using microstate analysis. The results suggest that deficits in P50 suppression in schizophrenia may be attributed to abnormal baseline sensory perception and adaptation. This finding provides new insights into the mechanisms of P50 suppression in the early stage of schizophrenia.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Psychology, Biological
Tzvetan Popov, Brigitte Rockstroh, Gregory A. Miller
Summary: This study found that individuals with schizophrenia exhibit poorer sensory gating, particularly in the A1 region, as well as in adjacent brain regions. In addition, the study suggests that endogenous connectivity evident in a sequence of activity from angular gyrus to portions of superior temporal gyrus may contribute to both normal and abnormal gating in schizophrenia.
Article
Psychiatry
Leilei Wang, Wanjun Zeng, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Xingguang Luo, Shuping Tan, Zhiren Wang, Chiang-Shan R. Li, Baopeng Tian, Li Tian, Chuanlian Ma, Yanli Li, Yunlong Tan
Summary: The study investigates the relationship between sensory gating deficits, childhood trauma, and schizophrenia onset. It is found that patients with first-episode schizophrenia have more severe childhood trauma experiences and sensory gating deficits. Sensory gating deficits might mediate the effects of childhood trauma on the onset of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Shuai Wang, Zijie Li, Xuejiao Wang, Jinhong Li, Xueru Wang, Jingyu Chen, Yingna Li, Changming Wang, Ling Qin
Summary: Auditory gating (AG) is an adaptive mechanism for filtering out redundant acoustic stimuli to protect the brain against information overload. The posterior parietal cortex (PPC) shows an intermediate level of AG in auditory thalamocortical circuits, with the strongest AG in the granular layer. AG in the PPC is determined by the integrated signal streams from the medial dorsal thalamic nucleus (MD) and auditory cortex (AC) in a bottom-up manner. A mouse model of schizophrenia (SZ) presents an AG deficit in the PPC, possibly inherited from the dysfunction of MD.
Article
Psychiatry
Qingyan Yang, Yong Zhang, Kebing Yang, Yajuan Niu, Fengmei Fan, Song Chen, Xingguang Luo, Shuping Tan, Zhiren Wang, Jinghui Tong, Fude Yang, Chiang-Shan R. Li, Yunlong Tan
Summary: This study aimed to investigate the relationship between serum level of kynurenine pathway (KP) metabolites and P50 auditory gating in patients with first-episode schizophrenia. The results showed significant associations between metabolite levels and auditory gating, suggesting that the KP might play an important role in sensory gating deficit in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Behavioral Sciences
Andrey T. Proshin
Summary: This article presents a comparative analysis of the characteristics of cholinergic and dopaminergic mechanisms associated with gating decline in healthy individuals and patients with schizophrenia, and discusses the differences in gating mechanisms between the two cohorts.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Jun-Rui Jian, Yen-Yun Lin, Lisa Tabor Connor, Chia-Hsiung Cheng
Summary: This study found a specific relationship between an individual's perceptual experience and the electrophysiological SG function of the right IFG.
NEUROSCIENCE LETTERS
(2022)
Article
Behavioral Sciences
Peter J. Hills, Martin R. Vasilev, Panarai Ford, Lucy Snell, Emma Whitworth, Tessa Parsons, Rebecca Morisson, Abigail Silveira, Bernhard Angele
Summary: The study found that sensory gating was related to positive and disorganized dimensions, smooth pursuit eye movement error was related to negative dimensions, while latent inhibition and prepulse inhibition were not related to any dimensions of schizotypy. These results suggest that the symptom clusters associated with different endophenotypes are largely independent of each other.
Article
Neurosciences
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle
Summary: This study investigated the potential of P50 sensory gating and prepulse inhibition ratios as surrogate markers for cognitive fatigue in people with multiple sclerosis (pwMS). The results showed that P50 sensory gating was correlated with subjective fatigue ratings. This study is the first to demonstrate fatigue-related disruption of sensory gating in pwMS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Saeka Tomatsu, Geehee Kim, Shinji Kubota, Kazuhiko Seki
Summary: This article investigates the role of presynaptic inhibition in proprioceptive signals and finds that it can modulate proprioceptive input based on muscle length. This presynaptic inhibition may be initiated by cortical signals and has an impact on stable motor output.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Sara de la Salle, Joelle Choueiry, Judy McIntosh, Hayley Bowers, Vadim Ilivitsky, Verner Knott
Summary: This study found that a subanesthetic dose of the NMDAR antagonist ketamine impaired auditory sensory gating, providing further evidence for the role of NMDAR hypofunction in schizophrenia.
PSYCHOPHARMACOLOGY
(2022)
Article
Biology
Baher A. Ibrahim, Caitlin A. Murphy, Georgiy Yudintsev, Yoshitaka Shinagawa, Matthew Banks, Daniel A. Llano
Summary: This study sheds light on a possible mechanism for modulating cortical population activity by gating in response to sensory stimuli. Through observations in the mouse auditory cortex and brain slice experiments, a cortical-thalamocortical-thalamic reticular nucleus circuit was implicated in modifying thalamic synchronization to recruit cortical neuron populations for sensory representations.
Article
Neurosciences
Toshio Shimizu, Yuki Nakayama, Kota Bokuda, Kazushi Takahashi
Summary: The study found enhanced cortical responses in somatosensory evoked potentials (SEP) in patients with amyotrophic lateral sclerosis (ALS), with no significant differences in sensory gating between patients and controls. The baseline amplitudes of certain components of SEP were significantly correlated with their gating ratios in ALS patients, indicating preserved sensory gating in the early stages of the disease.
Article
Psychiatry
Mengling Deng, Zhi Yang, Yanfei Ni, Lingli Zhu, Jiating Xu, Lifeng Zheng, Bo Zhou
Summary: This study investigated the impact of smoking cessation with varenicline on the serum concentration of olanzapine in patients with Schizophrenia. The results indicated that olanzapine concentrations increased nonlinearly in both the varenicline and placebo groups over the 12-week study period, but there was no significant difference between the two treatment groups.
FRONTIERS IN PSYCHIATRY
(2023)