Article
Pediatrics
Jessica L. Bettenhausen, Matt Hall, Stephanie K. Doupnik, Jessica L. Markham, James A. Feinstein, Jay G. Berry, James C. Gay
Summary: This retrospective analysis of mental health hospitalizations for rural children in the US found that although hospitalizations at children's and metropolitan non-children's hospitals had longer length of stay, patient outcomes were more favorable.
JOURNAL OF PEDIATRICS
(2021)
Article
Psychology, Developmental
Jason M. Nagata, Jonathan Chu, Kyle T. Ganson, Stuart B. Murray, Puja Iyer, Kelley Pettee Gabriel, Andrea K. Garber, Kirsten Bibbins-Domingo, Fiona C. Baker
Summary: The study found that longer screen time each day was prospectively associated with higher prevalence of conduct and oppositional defiant disorder, with the strongest association found between social media use and conduct disorder.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Paige E. Naylor, Jennifer L. Bruno, Sharon Bade Shrestha, Marcelle Friedman, Booil Jo, Allan L. Reiss, Tamar Green
Summary: This study investigated neuropsychiatric outcomes in children with Noonan syndrome and addressed limitations in previous research by focusing on prepubertal children, comparison to typically developing children, comprehensive neuropsychiatric evaluation, and controlling for overall cognitive abilities. Results showed that children with Noonan syndrome had elevated symptoms across ADHD, ASD, and ODD symptom clusters, and the group differences remained significant even after accounting for variations in intellectual functioning. The study revealed that Noonan syndrome children are at increased risk for a range of ADHD, ASD, and ODD associated symptoms, and a dimensional approach is important in assessing ASD symptoms in Noonan syndrome.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ravi Philip Rajkumar
Summary: Psychological therapies are the first-line treatment for childhood disruptive behavior disorders (DBDs), but many patients require adjunctive pharmacotherapy. This paper summarizes the findings of existing systematic reviews and updates them with recent clinical trials on the use of antipsychotics in children and adolescents with DBDs. The data suggests that risperidone appears to be effective in the short-term management of DBDs, but all available antipsychotics are associated with metabolic adverse effects.
Article
Endocrinology & Metabolism
Irem Sahin, Gokce Nur Say, Bahattin Avci, Neriman Kesim
Summary: Attention deficit hyperactivity disorder (ADHD) involves the role of neurosteroids, particularly allopregnanolone, in its pathogenesis. The study found that serum allopregnanolone levels were lower in children with ADHD, especially those with specific learning disorder and oppositional defiant disorder comorbidities. However, serum DHEA and DHEA-S levels were not significantly different compared to healthy children. Furthermore, there was a negative correlation between serum allopregnanolone levels and the severity of ADHD symptoms.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychiatry
Ebru Saglam, Ayhan Bilgic, Sedat Abusoglu, Ali Unlu, Abdullah Sivrikaya
Summary: This study found alterations in the levels of biochemical molecules related to the tryptophan metabolic pathway in children with ADHD, suggesting a potential role of TMP in the pathophysiology of ADHD-C.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Valentina Levantini, Pietro Muratori, Sara Calderoni, Emanuela Inguaggiato, Gabriele Masi, Annarita Milone, Alessandro Tonacci, Lucia Billeci
Summary: This study explored the relationship between callous-unemotional (CU) traits and gaze pattern deficits in adolescents, and found that parenting style played a moderating role in this relationship. Negative parenting style and reduced attention to emotional cues (eyes) may put adolescents with disruptive behavior disorder diagnosis at risk for severe outcomes.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Developmental
Mireia Rosa-Justicia, Melanie C. Saam, Itziar Flamarique, Roger Borras, Jilly Naaijen, Andrea Dietrich, Pieter J. Hoekstra, Tobias Banaschewski, Pascal Aggensteiner, Michael C. Craig, Arjun Sethi, Paramala Santosh, Ilyas Sagar-Ouriaghli, Celso Arango, Maria Jose Penzol, Daniel Brandeis, Julia E. Werhahn, Jeffrey C. Glennon, Barbara Franke, Marcel P. Zwiers, Jan K. Buitelaar, Ulrike M. E. Schulze, Josefina Castro-Fornieles
Summary: Disruptive behavior during childhood and adolescence is heterogeneous and associated with several psychiatric disorders. This study identifies three distinct subgroups within children and adolescents with disruptive behaviors, namely the High CU Traits subgroup, the ADHD and Affective Dysregulation subgroup, and the Low Severity subgroup. These subgroups differ in various clinical variables and highlight the importance of anxiety, affective problems, ADHD, proactive aggression, and CU traits in differentiating between subgroups.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Family Studies
William Byansi, Phionah Namatovu, Ozge Sensoy Bahar, Joshua Kiyingi, Josephine Nabayinda, Abel Mwebembezi, Apollo Kivumbi, Christopher Damulira, Jennifer Nattabi, Flavia Namuwonge, Mary M. McKay, Kimberly Hoagwood, Fred M. Ssewamala
Summary: This study found an association between family-level factors and behavioral difficulties among children in Uganda, suggesting that divorced and widowed families may require additional support in caring for children. Additionally, caregiver age was found to be associated with lower behavioral disorder symptoms among children.
CHILDREN AND YOUTH SERVICES REVIEW
(2022)
Article
Psychiatry
Rapson Gomez, Vasileios Stavropoulos, Andre Gomez, Taylor Brown, Shaun Watson
Summary: This study used regularized partial correlation network analysis to examine the structure of DSM-5 Oppositional Defiant Disorder (ODD) symptoms. The findings showed that anger was the most central symptom for both parent and teacher ratings, followed by argue and defy respectively. There were consistent connections between different symptoms across parent and teacher ratings.
Article
Psychology, Developmental
Christina Stadler, Christine M. Freitag, Arne Popma, Lucres Nauta-Jansen, Kerstin Konrad, Eva Unternaehrer, Katharina Ackermann, Anka Bernhard, Anne Martinelli, Helena Oldenhof, Malou Gundlach, Gregor Kohls, Martin Praetzlich, Meinhard Kieser, Ronald Limprecht, Nora M. Raschle, Noortje Vriends, Robert L. Trestman, Marietta Kirchner, Linda Kersten
Summary: This study aimed to confirm the efficacy of the START NOW program for female adolescents with CD or ODD. The results showed that while START NOW did not result in greater symptom reduction compared to standard care at post-treatment, it did show a clinically meaningful delayed treatment effect.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Teresa Del Giudice, Timo Lindenschmidt, Martin Hellmich, Christopher Hautmann, Manfred Doepfner, Anja Goertz-Dorten
Summary: The stability and effectiveness of the Treatment Program for Children with Aggressive Behavior (THAV) in reducing behavioral problems in children with oppositional defiant disorder (ODD) and conduct disorder (CD) were examined at a 10-month follow-up. The results showed that THAV effects remained stable and even partially improved over the follow-up period.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Astrid Braenden, Marit Coldevin, Pal Zeiner, Jan Stubberud, Annika Melinder
Summary: This study aimed to compare executive function in children with DMDD, ADHD, and ODD, and explore the associations between irritability and executive function. The results showed that children with DMDD exhibited worse emotion control and better cognitive flexibility compared to those with ADHD. No significant differences were found between DMDD, ADHD, and ODD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Shoko Sakamoto, Dai Miyawaki, Ayako Goto, Kaoru Hirai, Hiroki Hama, Shin Kadono, Sayaka Nishiura, Koki Inoue
Summary: The study revealed that maternal depression and anxiety may be one of the risk factors for children and adolescents to develop internet addiction. Care for maternal depression and anxiety could potentially contribute to intervention for children and adolescents with internet addiction.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Psychology, Clinical
Pascal-M Aggensteiner, Nathalie E. Holz, Boris W. Boettinger, Sarah Baumeister, Sarah Hohmann, Julia E. Werhahn, Jilly Naaijen, Shahrzad Ilbegi, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Renee Kleine Deters, Melanie C. Saam, Ulrike M. E. Schulze, David J. Lythgoe, Arjun Sethi, Michael C. Craig, Mathilde Mastroianni, Ilyas Sagar-Ouriaghli, Paramala J. Santosh, Mireia Rosa, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J. Penzol, Jorge Vidal, Barbara Franke, Marcel P. Zwiers, Jan K. Buitelaar, Susanne Walitza, Tobias Banaschewski, Daniel Brandeis
Summary: Brain imaging studies have shown differences in amygdala activity and skin conductance responses to emotional faces between children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) and typically developing peers. Subtyping based on aggression-related subtypes did not significantly impact amygdala activity, while stratification based on callous-unemotional (CU) traits was more sensitive and showed decreased amygdala activity in those with high CU traits. Our insights could be valuable for improved diagnostics and personalized treatment.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Oncology
Kelly L. Bolton, Ahmet Zehir, Ryan N. Ptashkin, Minal Patel, Dipti Gupta, Robert Sidlow, Elli Papaemmanuil, Michael F. Berger, Ross L. Levine
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2020)
Review
Cardiac & Cardiovascular Systems
Robert Sidlow, Amy E. Lin, Dipti Gupta, Kelly L. Bolton, David P. Steensma, Ross L. Levine, Benjamin L. Ebert, Peter Libby
Review
Hematology
Mariam T. Nawas, Johannes Schetelig, Frederik Damm, Ross L. Levine, Miguel-Angel Perales, Sergio A. Giralt, Marcel R. VanDenBrink, Maria E. Arcila, Ahmet Zehir, Elli Papaemmanuil, Anja Klussmeier, Alexander H. Schmidt, Stephanie Maiwald, Kelly L. Bolton, Roni Tamari
Summary: Clonal hematopoiesis refers to somatic mutations in hematopoietic stem and progenitor cells leading to clonal expansion, which increases with age; its role in hematopoietic cell transplantation is becoming increasingly important; post-transplant hematopoiesis is influenced by various factors, requiring more large-scale studies to establish a management approach for CH.
Article
Hematology
Andrew Dunbar, Kelly L. Bolton, Sean M. Devlin, Francisco Sanchez-Vega, Jianjiong Gao, Jodi Mones, Jonathan Wills, Daniel Kelly, Mirko Farina, Keith B. Cordner, Young Park, Sirish Kishore, Krishna Juluru, Neil M. Iyengar, Ross L. Levine, Ahmet Zehir, Wungki Park, Alok A. Khorana, Gerald A. Soff, Simon Mantha
Summary: This study identified that somatic tumor mutations of STK11, KRAS, CTNNB1, KEAP1, CDKN2B, and MET were associated with an increased risk of VTE in patients with solid tumors, highlighting the need for further validation and exploration of unique molecular signatures specific to individual tumor types.
Article
Multidisciplinary Sciences
Ditte Demontis, Raymond K. Walters, Veera M. Rajagopal, Irwin D. Waldman, Jakob Grove, Thomas D. Als, Soren Dalsgaard, Marta Ribases, Jonas Bybjerg-Grauholm, Maria Baekvad-Hansen, Thomas Werge, Merete Nordentoft, Ole Mors, Preben Bo Mortensen, Bru Cormand, David M. Hougaard, Benjamin M. Neale, Barbara Franke, Stephen Faraone, Anders D. Borglum
Summary: This study identified three genome-wide significant loci for ADHD comorbid with DBDs, with one locus on chromosome 11 found to be a strong risk locus across European and Chinese ancestries. The findings suggest an increased load of common risk variants in ADHD+DBDs compared to ADHD without DBDs, particularly in association with aggressive behavior.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Teng Gao, Ryan Ptashkin, Kelly L. Bolton, Christopher Fong, Barbara Spitzer, Kamal Menghrajani, Juan E. Arango Ossa, Yangyu Zhou, Elsa Bernard, Max Levine, Juan S. Medina Martinez, Yanming Zhang, Sebastia Franch-Exposito, Minal A. Patel, Lior Braunstein, Daniel Kelly, Mariko Yabe, Ryma Benayed, Nicole M. Caltabellotta, John Philip, Ederlinda Paraiso, Simon Mantha, David B. Solit, Luis Alberto Diaz, Michael F. Berger, Virginia M. Klimek, Ross L. Levine, Ahmet Zehir, Sean Devlin, Elli Papaemmanuil
Summary: This study jointly characterized gene mutations and mCAs in clonal hematopoiesis using peripheral blood sequencing data from cancer patients. Patients with composite genotypes in clonal hematopoiesis were found to have a higher risk of leukemia progression, with mCA identified as an independent risk factor for leukemia development.
NATURE COMMUNICATIONS
(2021)
Correction
Biochemistry & Molecular Biology
Elsa Bernard, Yasuhito Nannya, Robert P. Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan S. Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max F. Levine, Juan E. Arango, Yangyu Zhou, Francesc Sole, Catherine A. Cargo, Detlef Haase, Maria Creignou, Ulrich Germing, Yanming Zhang, Gunes Gundem, Araxe Sarian, Arjan A. van de Loosdrecht, Martin Jadersten, Magnus Tobiasson, Olivier Kosmider, Matilde Y. Follo, Felicitas Thol, Ronald F. Pinheiro, Valeria Santini, Ioannis Kotsianidis, Jacqueline Boultwood, Fabio P. S. Santos, Julie Schanz, Senji Kasahara, Takayuki Ishikawa, Hisashi Tsurumi, Akifumi Takaori-Kondo, Toru Kiguchi, Chantana Polprasert, John M. Bennett, Virginia M. Klimek, Michael R. Savona, Monika Belickova, Christina Ganster, Laura Palomo, Guillermo Sanz, Lionel Ades, Matteo Giovanni Della Porta, Alexandra G. Smith, Yesenia Werner, Minal Patel, Agnes Viale, Katelynd Vanness, Donna S. Neuberg, Kristen E. Stevenson, Kamal Menghrajani, Kelly L. Bolton, Pierre Fenaux, Andrea Pellagatti, Uwe Platzbecker, Michael Heuser, Peter Valent, Shigeru Chiba, Yasushi Miyazaki, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H. Jansen, Jose Cervera, Yoshiko Atsuta, Norbert Gattermann, Benjamin L. Ebert, Rafael Bejar, Peter L. Greenberg, Mario Cazzola, Eva Hellstrom-Lindberg, Seishi Ogawa, Elli Papaemmanuil
Correction
Multidisciplinary Sciences
Ditte Demontis, Raymond K. Walters, Veera M. Rajagopal, Irwin D. Waldman, Jakob Grove, Thomas D. Als, Soren Dalsgaard, Marta Ribases, Jonas Bybjerg-Grauholm, Maria Baekvad-Hansen, Thomas Werge, Merete Nordentoft, Ole Mors, Preben Bo Mortensen, Bru Cormand, David M. Hougaard, Benjamin M. Neale, Barbara Franke, Stephen V. Faraone, Anders D. Borglum
NATURE COMMUNICATIONS
(2021)
Correction
Cell Biology
Nuria Mencia-Trinchant, Matthew J. MacKay, Christopher Chin, Ebrahim Afshinnekoo, Jonathan Foox, Cem Meydan, Daniel Butler, Christopher Mozsary, Nicholas A. Vernice, Charlotte Darby, Michael C. Schatz, Susan M. Bailey, Ari M. Melnick, Monica L. Guzman, Kelly Bolton, Lior Z. Braunstein, Francine Garrett-Bakelman, Ross L. Levine, Duane C. Hassane, Christopher E. Mason
Correction
Biochemistry & Molecular Biology
Elsa Bernard, Yasuhito Nannya, Robert P. Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan S. Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max F. Levine, Juan E. Arango, Yangyu Zhou, Francesc Sole, Catherine A. Cargo, Detlef Haase, Maria Creignou, Ulrich Germing, Yanming Zhang, Gunes Gundem, Araxe Sarian, Arjan A. van de Loosdrecht, Martin Jadersten, Magnus Tobiasson, Olivier Kosmider, Matilde Y. Follo, Felicitas Thol, Ronald F. Pinheiro, Valeria Santini, Ioannis Kotsianidis, Jacqueline Boultwood, Fabio P. S. Santos, Julie Schanz, Senji Kasahara, Takayuki Ishikawa, Hisashi Tsurumi, Akifumi Takaori-Kondo, Toru Kiguchi, Chantana Polprasert, John M. Bennett, Virginia M. Klimek, Michael R. Savona, Monika Belickova, Christina Ganster, Laura Palomo, Guillermo Sanz, Lionel Ades, Matteo Giovanni Della Porta, Alexandra G. Smith, Yesenia Werner, Minal Patel, Agnes Viale, Katelynd Vanness, Donna S. Neuberg, Kristen E. Stevenson, Kamal Menghrajani, Kelly L. Bolton, Pierre Fenaux, Andrea Pellagatti, Uwe Platzbecker, Michael Heuser, Peter Valent, Shigeru Chiba, Yasushi Miyazaki, Carlo Finelli, Maria Teresa Voso, Lee-Yung Shih, Michaela Fontenay, Joop H. Jansen, Jose Cervera, Yoshiko Atsuta, Norbert Gattermann, Benjamin L. Ebert, Rafael Bejar, Peter L. Greenberg, Mario Cazzola, Eva Hellstrom-Lindberg, Seishi Ogawa, Elli Papaemmanuil
Article
Neurosciences
Martha Martinez-Banfi, Jorge Velez, Moises R. Mebarak Chams, Mauricio Arcos-Holzinger, Johan E. Acosta-Lopez, Ricardo Garcia, Maria Victoria Perea, Mauricio Arcos-Burgos, Valentina Ladera
Summary: The study evaluated the performance of a short protocol for detecting HIV-associated neurocognitive disorders (HAND), showing promising results in a Caribbean community. Community-specific cut-off values for HAND diagnosis may improve screening accuracy and patient treatment.
Article
Genetics & Heredity
Liliana Elizabeth Rodriguez-Salgado, Claudia Tamar Silva-Aldana, Esteban Medina-Mendez, Jose Bareno-Silva, Mauricio Arcos-Burgos, Daniel Felipe Silgado-Guzman, Carlos M. Restrepo
Summary: This study aimed to determine the prevalence of secondary findings (SF) in a Colombian population for 59 genes associated with 27 genetic diseases. The results showed that 8.13% of patients had pathogenic variants in 11 genes. No association was found between socio-demographic variables and the need to report SF. This study provides the first approach to the spectrum of actionable pathogenic variants in the Colombian population.
Article
Genetics & Heredity
Daniel J. Weiner, Emi Ling, Serkan Erdin, Derek J. C. Tai, Rachita Yadav, Jakob Grove, Jack M. Fu, Ajay Nadig, Caitlin E. Carey, Nikolas Baya, Jonas Bybjerg-Grauholm, Sabina Berretta, Evan Z. Macosko, Jonathan Sebat, Luke J. O'Connor, David M. Hougaard, Anders D. Borglum, Michael E. Talkowski, Steven A. McCarroll, Elise B. Robinson
Summary: Using a new statistical approach, this study identified the 33-Mb p-arm of chromosome 16 (16p) as harboring the greatest excess of autism's common polygenic influences. Both the rare 16p11.2 deletion and common variations lead to decreased gene expression across the entire 16p region, with transcriptional effects correlated at the individual gene level.
Article
Multidisciplinary Sciences
Oscar M. Vidal, Jorge I. Velez, Mauricio Arcos-Burgos
Summary: Attention deficit/hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder. This study examined the impact of non-synonymous SNPs in the ADGRL3 gene on ADHD development. The findings suggest that these mutations disrupt the normal structure of ADGRL3 and may affect its metabolic regulation, potentially linking ADHD to the pathogenesis of diabetes mellitus.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Yina D. Carrillo, Paula Rueda-Gaitan, Orlando Gualdron, Carlos Estrada-Serrato, Taryn A. Castro-Cuesta, Olga Londono, Luna Rodriguez-Salazar, Mario Isaza-Ruget, Mauricio Arcos-Burgos, Juan Javier Lopez Rivera
Summary: Copy number variants (CNVs) are a major cause of neurodevelopmental delay and congenital malformations, and chromosomal microarray analysis (CMA) is the gold standard for molecular characterization of CNVs. We applied CMA in the clinical diagnostic process of patients as requested by their medical provider. Among 3380 patients, we identified 830 CNVs with potential clinical significance, and 10.6% of them were most likely the final cause of the patients' clinical phenotype. The rate of pathogenic or likely pathogenic findings among patients with CNVs was 60.75% for neurodevelopmental phenotypes and 59% for epileptic phenotypes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
