4.2 Article

Gender-Specific Association of the Brain-Derived Neurotrophic Factor Gene with Attention-Deficit/Hyperactivity Disorder

Journal

PSYCHIATRY INVESTIGATION
Volume 7, Issue 4, Pages 285-290

Publisher

KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.4306/pi.2010.7.4.285

Keywords

Association studies; Attention-deficit/hyperactivity disorder; Brain-derived neurotrophic factor; Continuous performance test; Single nucleotide polymorphism

Categories

Funding

  1. Korean Neuropsychiatry Research Foundation

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Objective Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism. Methods We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test on 151 trios, and compared the results of a continuous performance test (CPT) according to the genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, rs16917204) in the BDNF gene. Results In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls (p=0.024, odds ratio=3.00). The T-G-G haplotype was significantly less frequent (p=0.005) and A-G-G was more frequent (p=0.048) in girls with ADHD than in control girls (global p=0.027). A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype (p=0.026) and an interaction effect of the rs11030101 genotype and gender (p=0.032) in ADHD probands. Conclusion These results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population. Psychiatry Investig 2010;7:285-290

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