Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Randall L. Kuffel, Amy L. Byers, Brie Williams, Richard Fortinsky, Yixia Li, Michael A. Ruderman, Lisa C. Barry
Summary: This study examines the prevalence of dementia and mild cognitive impairment (MCI) among incarcerated individuals in the United States. The findings highlight the importance of understanding the link between cognitive impairment and incarceration in order to inform healthcare optimization and prevention strategies for this vulnerable population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Clinical Neurology
Shintaro Takenoshita, Seishi Terada, Tomokazu Inoue, Taku Kurozumi, Norihito Yamada, Ryozo Kuwano, Shigeru Suemitsu
Summary: This study investigated the prevalence of dementia and potential risk factors among individuals with intellectual disability without Down syndrome. The results showed a higher prevalence of dementia in this population compared to the general population, but adequate education, prevention of head trauma and stroke, and treatments of hypertension and depression may reduce the risk of dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Jens Bohlken, Steffi Riedel-Heller, Gilles Steininger, Karel Kostev, Bernhard Michalowsky
Summary: The study in Germany from 2015 to 2019 showed a decrease in the prevalence and incidence rates of dementia, particularly in patients aged 80 and older. However, the prevalence and incidence rates of mild cognitive impairment remained stable. Overall, there was a slight decrease in the number of dementia patients while the number of mild cognitive impairment patients increased.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Yi-Long Huang, Chao-Hsiung Lin, Tsung-Hsien Tsai, Chen-Hua Huang, Jie-Ling Li, Liang-Kung Chen, Chun-Hsien Li, Ting-Fen Tsai, Pei-Ning Wang
Summary: This study utilized untargeted metabolomics analysis to characterize plasma metabolites in MCI patients progressing to AD and stable MCI patients. A 20-metabolite signature panel associated with the presence and progression of AD was identified using machine learning, offering predictive value for conversion from MCI to AD. Additionally, the bacteria-generated metabolite indole-3-propionic acid was identified as a predictor of AD progression, suggesting a role for gut microbiota in AD pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Meng Wang, Tolulope T. Sajobi, David B. Hogan, Aravind Ganesh, Dallas P. Seitz, Thierry Chekouo, Nils D. Forkert, Michael J. Borrie, Richard Camicioli, Ging-Yuek Robin Hsiung, Mario Masellis, Paige Moorhouse, Maria Carmela Tartaglia, Zahinoor Ismail, Eric E. Smith
Summary: This study assesses experts' beliefs on important predictors of developing dementia in persons with mild cognitive impairment (MCI). Age, CSF analysis, FDG-PET findings, hippocampal atrophy, MoCA (or MMSE) score, parkinsonism, apathy, psychosis, informant report of cognitive symptoms, and global atrophy were identified as the ten most important predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Sanjay Nagaraj, Tim Q. Duong
Summary: A deep learning algorithm was developed to accurately classify patients into four groups. Through neural network algorithm and simplified scoring model, a few significant neurocognitive tests were identified for accurate classification.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Katarina Kouter, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Tina Milos, Lucija Tudor, Suzana Uzun, Ninoslav Mimica, Nela Pivac, Alja Videtic Paska
Summary: Due to the increasing number of progressive dementias, studies are being conducted to determine risk factors, biomarkers, and mechanisms for differentiating between normal aging, MCI, and dementia. This study investigated the association of BDNF and COMT gene expression and methylation with the development of AD. The results showed higher BDNF expression in MCI subjects compared to AD individuals, suggesting its potential as a marker for distinguishing between MCI and AD. No difference in COMT gene expression was found.
Article
Neurosciences
Seung Wan Suh, You Joung Kim, Kyung Phil Kwak, Kiwon Kim, Moon-Doo Kim, Byung-Soo Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seok Woo Moon, Kyung Won Park, Jong-Il Park, Joon Hyuk Park, Jae Nam Bae, Jiyeong Seo, Su Jeong Seong, Sang Joon Son, Il-Seon Shin, Seung-Ho Ryu, Kang Joon Lee, Nam-Jin Lee, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Chang Uk Lee, Sung Man Chang, Hyun-Ghang Jeong, Maeng Je Cho, Seong-Jin Cho, Jin Hyeong Jhoo, Young Min Choe, Ji Won Han, Ki Woong Kim
Summary: The prevalence of dementia in elderly populations in Korea showed a nonsignificant decrease between 2008 and 2017, with Alzheimer's disease also decreasing slightly while mild cognitive impairment remained stable.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Chris Oliver, Dawn Adams, Anthony J. Holland, Stephanie S. G. Brown, Sarah Ball, Karen Dodd, Janet Carr
Summary: Individuals with Down syndrome are at risk for early onset Alzheimer's disease. Single point assessment can effectively diagnose acquired mild cognitive impairment (AMCI) in most individuals with Down syndrome. The prevalence of AMCI peaks at two age ranges, indicating that the risk for Alzheimer's disease onset may be influenced by other factors.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Neurosciences
Sung Woo Park, Mi Kyoung Seo, Roger S. McIntyre, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Seon-Cheol Park, Lyang Huh, Jung Goo Lee
NEUROSCIENCE LETTERS
(2018)
Article
Neurosciences
Mi Kyoung Seo, Jung Goo Lee, Sung Woo Park
NEUROSCIENCE LETTERS
(2019)
Correction
Neurosciences
Jung Goo Lee, Young Sup Woo, Sung Woo Park, Dae-Hyun Seog, Mi Kyoung Seo, Won-Myong Bahk
Article
Neurosciences
Jung Goo Lee, Young Sup Woo, Sung Woo Park, Dae-Hyun Seog, Mi Kyoung Seo, Won-Myong Bahk
Article
Multidisciplinary Sciences
Mi Kyoung Seo, Le Thi Hien, Min Kyung Park, Ah Jeong Choi, Dae-Hyun Seog, Seong-Ho Kim, Sung Woo Park, Jung Goo Lee
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Seon-gu Kim, Dae-Hyun Seog, Won-Myong Bahk, Seong-Ho Kim, Sung Woo Park, Jung Goo Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Ah Jeong Choi, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Summary: Research indicates that an enriched environment in early life may enhance the ability to cope with adult stress through epigenetic modification, preventing depression-like behavior induced by chronic stress and preserving expression and modification of the p11 gene. These findings demonstrate the positive effects of early-life environments on adult mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Young Sup Woo, Won-Myong Bahk, Jeong Seok Seo, Young-Min Park, Won Kim, Jong-Hyun Jeong, Se-Hoon Shim, Jung Goo Lee, Seung-Ho Jang, Chan-Mo Yang, Sheng-Min Wang, Myung Hun Jung, Hyung Mo Sung, Il Han Choo, Bo-Hyun Yoon, Sang-Yeol Lee, Duk-In Jon, Kyung Joon Min
Summary: This review compared the recommendations from the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) 2021 to four global clinical practice guidelines (CPGs) for depression. Despite some differences, the recommendations from KMAP-DD 2021 were similar to those from other CPGs. Although the KMAP-DD 2021 is an expert consensus-based guideline with inherent limitations, it can be helpful for Korean psychiatrists in making decisions in clinical settings, especially for some clinical situations lacking evidence from rigorously designed clinical trials.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Neurosciences
Jeong Seok Seo, Won-Myong Bahk, Young Sup Woo, Young-Min Park, Won Kim, Jong-Hyun Jeong, Se-Hoon Shim, Jung Goo Lee, Seung-Ho Jang, Chan-Mo Yang, Sheng-Min Wang, Myung Hun Jung, Hyung Mo Sung, Il Han Choo, Bo-Hyun Yoon, Sang-Yeol Lee, Duk-In Jon, Kyung Joon Min
Summary: The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) has undergone four revisions since its development in 2002, with little change in recent years due to a lack of new drug or treatment strategies. The questionnaire's overall structure was maintained, and recommended treatment strategies were derived statistically.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Review
Neurosciences
Jung Goo Lee, Young Sup Woo, Sung Woo Park, Dae-Hyun Seog, Mi Kyoung Seo, Won-Myong Bahk
Summary: Bipolar disorder is a mental illness characterized by extreme mood swings, but the reasons for its repeated episodes and the lack of effective treatments for both manic and depressive episodes are still unknown.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Jung An Lee, Sehoon Jeong, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Summary: In an animal model of chronic unpredictable stress-induced depression, chronic treatment with the mGlu2/3 receptor antagonist LY341495 showed antidepressant effects possibly through the activation of hippocampal mTORC1 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Young Sup Woo, Won-Myong Bahk, Jong-Hyun Jeong, Jung Goo Lee, Won Kim, InKi Sohn, Sung-Yong Park, Se-Hoon Shim, Jeong Seok Seo, I. L. Han Choo, Chan-Mo Yang, Myung Hun Jung, Duk-In Jon, Moon-Do Kim, Bo-Hyun Yoon
Summary: The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) has been revised to reflect recent progress in the treatment of bipolar disorder. The revised guidelines provide recommendations for the pharmacological treatment of manic episodes, depressive episodes, and mixed features. The recommendations take into account the evolution of social culture and healthcare system in Korea, as well as recent evidence regarding pharmacotherapy for bipolar disorder.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Seung-Ho Jang, Won-Myong Bahk, Young Sup Woo, Jeong Seok Seo, Young-Min Park, Won Kim, Jong-Hyun Jeong, Se-Hoon Shim, Jung Goo Lee, Duk-In Jon, Kyung Joon Min
Summary: The Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) is an expert consensus guideline for depressive disorder created in 2002 and has undergone four revisions. This study examined the changes in the KMAP-DD survey content and recommendations for each period. The results showed that in mild depressive symptoms, antidepressant (AD) monotherapy was preferred, but in severe depression or with psychotic features, a combination of AD and atypical antipsychotics (AD + AAP) was preferred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Jong-Hyun Jeong, Won-Myong Bahk, Young Sup Woo, Bo-Hyun Yoon, Jung Goo Lee, Won Kim, InKi Sohn, Sung -Yong Park, Se-Hoon Shim, Jeong Seok Seo, I. L. Han Choo, Chan-Mo Yang, Myung Hun Jung, Duk-In Jon, Moon-Doo Kim
Summary: The objective of this study was to compare the treatment recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2022 (KMAP-BP 2022) with other recently published guidelines. The KMAP-BP 2022 guidelines were similar to other guidelines, reflecting current changes in prescription patterns for bipolar disorder based on accumulated research data. Strong preference for combination therapy was characteristic of KMAP-BP 2022, predominantly in the treatment of psychotic mania, mixed mania, and psychotic depression.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Young Sup Woo, Jung Wan Hong, Se-Hoon Shim, Hyung Mo Sung, Jeong Seok Seo, Sung-Yong Park, Jung Goo Lee, Bo-Hyun Yoon, Won-Myong Bahk
Summary: This study examined the prevalence of adult ADHD and its association with common psychiatric conditions in a community sample in Korea. The results showed a significant association between ADHD and depression as well as bipolar disorder.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)