Article
Clinical Neurology
Florian Johannes Muecke, Marc Petrus Hendriks, Christian Guenther Bien, Philip Grewe
Summary: The study found a mismatch between subjective and objective memory functioning in patients with epilepsy, with depressive symptoms playing a crucial role in explaining this discrepancy. Moreover, the relationship between objective memory change and quality of life is mediated by subjective memory change and depressive mood.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Kuniyoshi Toyoshima, Takeshi Inoue, Jiro Masuya, Yota Fujimura, Shinji Higashi, Ichiro Kusumi
Summary: This study investigated the impact of stressful life events on functional disability and examined the mediating effects of depressive symptoms and subjective cognitive dysfunction. The results showed that negative stressful life events directly and indirectly influenced functional disability through depressive symptoms and subjective cognitive dysfunction. Positive stressful life events indirectly affected functional disability through depressive symptoms and subjective cognitive dysfunction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Deborah Pacifico, Serena Sabatini, Maddalena Fiordelli, Emiliano Albanese
Summary: The study found that both SCD and SMD were associated with poorer objective cognitive/memory performance, as well as greater disability and more depressive symptoms. Disability fully mediated the associations between poorer objective cognitive and memory performance with subjective cognitive and memory decline.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Qiongqiong Wu, Xiaoyi Wang, Ying Wang, Yu-Jun Long, Jing-Ping Zhao, Ren-Rong Wu
Summary: This review focuses on the causal mechanisms and treatment options for the negative symptoms and cognitive dysfunction in schizophrenia, providing insights into potential therapeutic strategies for the future.
NEUROSCIENCE BULLETIN
(2021)
Article
Psychology, Multidisciplinary
Mahmoud Mohamed Emam, Nasser Said Gomaa Abdelrasheed, Ehab Omara
Summary: This study examines the associations between Omani adolescents' depressive symptoms and negative cognition, emotional and behavioral difficulties, and negative life events. Findings show that emotional and behavioral difficulties and negative life events have direct effects on adolescents' depressive symptoms. Additionally, it is found that negative cognition may increase vulnerability to depression among Omani adolescents through emotional and behavioral difficulties and negative life events.
CURRENT PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Jonas Montvidas, Virginija Adomaitiene, Darius Leskauskas, Sonia Dollfus
Summary: This study found that there is a significant correlation between negative symptoms and patients' health-related quality of life (HRQoL), while cognitive deficits do not significantly correlate with HRQoL. The Self-evaluation of Negative Symptoms scale (SNS) can be used as a screening tool in clinical practice to predict the HRQoL of patients with schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yuri Sasaki, Yugo Shobugawa, Ikuma Nozaki, Daisuke Takagi, Yuiko Nagamine, Masafumi Funato, Yuki Chihara, Yuki Shirakura, Kay Thi Lwin, Poe Ei Zin, Thae Zarchi Bo, Tomofumi Sone, Hla Hla Win
Summary: This study investigated the association between objective and subjective SES with depressive symptoms in older adults in Myanmar. The findings revealed that only low subjective SES was significantly associated with depressive symptoms after adjusting for objective SES and other factors. This association was stronger in rural areas.
Article
Rheumatology
Sudha Raghunath, Emma K. Guymer, Yifat Glikmann-Johnston, Vera Golder, Rangi Kandane Rathnayake, Eric F. Morand, Julie C. Stout, Alberta Hoi
Summary: Cognitive symptoms are common in SLE patients, but they are not directly associated with objective cognitive dysfunction. Depression, anxiety, and fibromyalgia are more consistently related to patient-reported cognitive symptoms. These factors have a significant impact on the quality of life of patients. Understanding the discrepancy between patient-reported cognitive symptoms and cognitive test performance is crucial for improving care in this area of unmet need.
Article
Gastroenterology & Hepatology
Dami Ko, Mary S. Dietrich, Katherine A. Gifford, Sheila H. Ridner
Summary: This study found that there is a fair correlation between the subjective cognition assessments of liver transplant recipients and their caregivers and the objective cognitive assessments. Caregivers may provide more accurate estimation of cognitive functioning in liver transplant recipients compared to the recipients themselves.
LIVER TRANSPLANTATION
(2022)
Article
Clinical Neurology
Xiaosi Huang, Shunkai Lai, Xiaodan Lu, Ying Wang, Yiliang Zhang, Guanmao Chen, Pan Chen, Kaiwei Ye, Manying Duan, Kailin Song, Shuming Zhong, Yanbin Jia
Summary: This study reveals the features and correlation between cognitive impairments and brain biochemical abnormalities in depressed patients with gastrointestinal symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Isabel Jaramillo, Marlene Karl, Luisa Bergunde, Judith T. Mack, Victoria Weise, Kerstin Weidner, Wei Gao, Susann Steudte-Schmiedgen, Susan Garthus-Niegel
Summary: This study investigated the association between negative childbirth experiences and long-term glucocorticoids, and found that a negative objective birth experience was associated with an increased HairF/HairE ratio, which may be a biomarker for identifying women at risk for developing postpartum depression (PPD). Subjective birth experience was not directly related to hair cortisol concentrations, but was a significant predictor for PPD symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Health Care Sciences & Services
Sunhae Kim, Kounseok Lee
Summary: This study examined depressive symptoms among elderly individuals with subjective memory complaints (SMCs) through network analysis. The results showed that depressed mood and anhedonia were the most important factors in the subjective cognitive decline group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Psychiatry
Maria Recio-Barbero, Rafael Segarra, Arantzazu Zabala, Eduardo Gonzalez-Fraile, Ana Gonzalez-Pinto, Javier Ballesteros
Summary: There is currently insufficient evidence to support the use of alpha 7 nAChR agonists as an effective adjunct treatment for enhancing cognition and negative symptoms in patients with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Yanhui Li, Gurpreet Rekhi, Mei San Ang, Jimmy Lee
Summary: This study examines the association between Negative Symptoms (NS) dimensions and Health-related Quality of Life (HRQoL) in schizophrenia. The results show that lower severity of NS, specifically in the Motivation and Pleasure (MAP) dimension, and the asociality domain, is associated with higher HRQoL. Therefore, targeting NS, particularly MAP and asociality, is important for improving HRQoL in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Felix Brandl, Franziska Knolle, Mihai Avram, Claudia Leucht, Igor Yakushev, Josef Priller, Stefan Leucht, Sibylle Ziegler, Klaus Wunderlich, Christian Sorg
Summary: Negative symptoms in patients with schizophrenia are highly prevalent and debilitating. This study found that impaired model-free reward prediction influence is a mechanism for negative symptoms in schizophrenia, and it is associated with reduced associative striatum dopamine and executive dysfunction.
Article
Geriatrics & Gerontology
Hideaki Shimizu, Takaaki Mori, Taku Yoshida, Ayumi Tachibana, Tomoki Ozaki, Yuta Yoshino, Shinichiro Ochi, Naomi Sonobe, Teruhisa Matsumoto, Kenjiro Komori, Jun-ichi Iga, Toshiharu Ninomiya, Shu-ichi Ueno, Manabu Ikeda
Summary: A study shows that the prevalence of dementia is increasing in Japan, which has the world's highest ageing population. This suggests that factors beyond ageing are contributing to the rising number of older people with dementia. To control the increase in dementia cases, it is necessary to study the trends in incidence, mortality, and prognosis of dementia, as well as the factors that promote or protect against dementia, and develop preventive strategies.
Article
Psychiatry
Yu Funahashi, Yuta Yoshino, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study investigated the global expression changes of miRNA in plasma exosomes derived from treatment-resistant schizophrenia patients. The results showed significant upregulation of miR-675-3p expression after clozapine treatment.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Takashi Tsuboi, Yoshikazu Takaesu, Naomi Hasegawa, Shinichiro Ochi, Kentaro Fukumoto, Kazutaka Ohi, Hiroyuki Muraoka, Tsuyoshi Okada, Funitoshi Kodaka, Shun Igarashi, Hitoshi Iida, Hiroko Kashiwagi, Hikaru Hori, Kayo Ichihashi, Kazuyoshi Ogasawara, Naoki Hashimoto, Jun-Ichi Iga, Toshinori Nakamura, Masahide Usami, Tatsuya Nagasawa, Mikio Kido, Hiroshi Komatsu, Hirotaka Yamagata, Kiyokazu Atake, Ryuji Furihata, Saya Kikuchi, Tadasu Horai, Masahiro Takeshima, Yoji Hirano, Manabu Makinodan, Junya Matsumoto, Kenichiro Miura, Akitoyo Hishimoto, Shusuke Numata, Hisashi Yamada, Norio Yasui-Furukori, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The use of electroconvulsive therapy (ECT) may reduce the need for anxiolytic and sleep medication in patients with major depressive disorder (MDD). However, there was no significant difference in anxiolytic and sleep medication use between the ECT and non-ECT groups in patients with schizophrenia (SZ).
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Neurosciences
Rie Hosokawa, Yuta Yoshino, Yu Funahashi, Fumie Horiuchi, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study investigates the expression of miRNA and mRNA in peripheral blood to explore a diagnostic biomarker for autism spectrum disorder (ASD). The results suggest that upregulated expression of miR-15b-5p may serve as a useful diagnostic marker for ASD and it may regulate the expression of TGFBR3 mRNA.
Article
Multidisciplinary Sciences
Hirotaka Yamagata, Ryouichi Tsunedomi, Toshiharu Kamishikiryo, Ayumi Kobayashi, Tomoe Seki, Masaaki Kobayashi, Kosuke Hagiwara, Norihiro Yamada, Chong Chen, Shusaku Uchida, Hiroyuki Ogihara, Yoshihiko Hamamoto, Go Okada, Manabu Fuchikami, Jun-ichi Iga, Shusuke Numata, Makoto Kinoshita, Takahiro A. Kato, Ryota Hashimoto, Hiroaki Nagano, Shuichi Ueno, Yasumasa Okamoto, Tetsuro Ohmori, Shin Nakagawa
Summary: By studying biomarkers for predicting antidepressant responses, we identified genes associated with antidepressant responsiveness and confirmed their differential expression through molecular biology experiments. Further research indicated an association between antidepressant responses and inflammation, which could be valuable for future treatment strategies for depression.
Article
Neurosciences
Hitoshi Iida, Tsuyoshi Okada, Kiyotaka Nemoto, Naomi Hasegawa, Shusuke Numata, Kazuyoshi Ogasawara, Kenichiro Miura, Junya Matsumoto, Hikaru Hori, Jun-ichi Iga, Kayo Ichihashi, Naoki Hashimoto, Hisashi Yamada, Kazutaka Ohi, Norio Yasui-Furukori, Kentaro Fukumoto, Takashi Tsuboi, Masahide Usami, Ryuji Furihata, Yoshikazu Takaesu, Akitoyo Hishimoto, Hiroyuki Muraoka, Eiichi Katsumoto, Tatsuya Nagasawa, Shinichiro Ochi, Hiroshi Komatsu, Saya Kikuchi, Masahiro Takeshima, Toshiaki Onitsuka, Shinichiro Tamai, Chika Kubota, Ken Inada, Koichiro Watanabe, Hiroaki Kawasaki, Ryota Hashimoto
Summary: The EGUIDE project was launched in 2016 to disseminate, educate, and validate psychiatric clinical practice guidelines. This study compared the effectiveness of web-based courses and face-to-face courses offered by the project. The results showed that web-based courses were rated as more satisfying than expected and there were no significant differences in satisfaction and clinical knowledge between the two formats. This suggests that web-based courses could be widely adopted alongside face-to-face courses after the COVID-19 pandemic.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Urology & Nephrology
Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya
Summary: This study aimed to examine the associations between urinary albumin-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) levels with brain atrophy and white matter lesion volume (WMLV) in a large-scale community-dwelling older population of Japanese. The results showed that higher UACR levels were significantly associated with lower total brain volume-to-intracranial volume ratio (TBV/ICV) and higher WMLV-to-ICV ratio. Lower eGFR levels were associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. Higher UACR levels were also associated with lower regional brain volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio.
Article
Neurosciences
Hiroaki Mori, Yuta Yoshino, Jun-ichi Iga, Shinichiro Ochi, Yu Funahashi, Kiyohiro Yamazaki, Hiroshi Kumon, Yuki Ozaki, Shu-ichi Ueno
Summary: In this study, the gene expression levels in the brain of 3xTg-AD model mice were explored to understand the molecular pathological changes of Alzheimer's disease (AD) from early to late stages. The study found changes in immune response and GABAergic neurotransmission in the brain of the mice from early to late stages of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Toshiaki Onitsuka, Tsuyoshi Okada, Naomi Hasegawa, Takashi Tsuboi, Jun-ichi Iga, Norio Yasui-Furukori, Naoki Yamada, Hikaru Hori, Hiroyuki Muraoka, Kazutaka Ohi, Kazuyoshi Ogasawara, Shinichiro Ochi, Masahiro Takeshima, Kayo Ichihashi, Kentaro Fukumoto, Hitoshi Iida, Hisashi Yamada, Ryuji Furihata, Manabu Makinodan, Yoshikazu Takaesu, Shusuke Numata, Hiroshi Komatsu, Akitoyo Hishimoto, Mikio Kido, Kiyokazu Atake, Hirotaka Yamagata, Saya Kikuchi, Naoki Hashimoto, Masahide Usami, Eiichi Katsumoto, Takeshi Asami, Chika Kubota, Junya Matsumoto, Kenichiro Miura, Yoji Hirano, Koichiro Watanabe, Ken Inada, Ryota Hashimoto
Summary: This study investigated the use of psychotropic medications among schizophrenia patients in Japan who received long-acting injectable antipsychotics (LAIs) or oral antipsychotics (OAPs). The results showed that the LAI group had higher rates of polypharmacy antipsychotics, number of antipsychotics, and chlorpromazine equivalents compared to the non-LAI group. However, the LAI group had a lower rate of concomitant use of hypnotic and/or antianxiety medication than the non-LAI group. The study concluded that clinicians should consider monotherapy for the treatment of schizophrenia, especially by reducing concomitant use of antipsychotics in the LAI group and reducing hypnotic and/or antianxiety medication in the non-LAI group.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Naoki Hashimoto, Norio Yasui-Furukori, Naomi Hasegawa, Shuhei Ishikawa, Hikaru Hori, Hitoshi Iida, Kayo Ichihashi, Kenichiro Miura, Junya Matsumoto, Shusuke Numata, Fumitoshi Kodaka, Ryuji Furihata, Kazutaka Ohi, Kazuyoshi Ogasawara, Jun-ichi Iga, Hiroyuki Muraoka, Hiroshi Komatsu, Masahiro Takeshima, Kiyokazu Atake, Mikio Kido, Toshinori Nakamura, Taishiro Kishimoto, Akitoyo Hishimoto, Toshiaki Onitsuka, Tsuyoshi Okada, Shinichiro Ochi, Tatsuya Nagasawa, Manabu Makinodan, Hiroki Yamada, Takashi Tsuboi, Hisashi Yamada, Ken Inada, Koichiro Watanabe, Ryota Hashimoto
Summary: The study aimed to compare psychotropic prescriptions in Japan between hospital admission and discharge, aligning them with international standards and reducing facility differences. Patients who received monotherapy with the main drug at admission were likely to continue with monotherapy at discharge. Polypharmacy was more common in patients who switched from monotherapy to polypharmacy. Over 10% of patients had no changes in prescription throughout their hospital stay.
Article
Neurosciences
Hiroshi Kumon, Yuta Yoshino, Tomoki Ozaki, Yu Funahashi, Hiroaki Mori, Mariko Ueno, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study aimed to replicate previous research and focused on apoptotic-related gene expression changes in fetal brains exposed to haloperidol during pregnancy. Using RNA sequencing and qPCR methods, the up-regulation of Cdkn1a and Apaf1 mRNA expression in the hippocampus of offspring was successfully validated, and the dose-dependent upregulation of both mRNA expressions by haloperidol and aripiprazole was confirmed in in vitro experiments.
BRAIN RESEARCH BULLETIN
(2023)
Article
Geriatrics & Gerontology
Ayumi Tachibana, Jun-ichi Iga, Yasuko Tatewaki, Benjamin Thyreau, Hongkun Chen, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-ichi Ueno
Summary: The aim of this study was to determine the association between blood pressure (BP) and enlarged perivascular spaces (EPVS) volumes, and to examine the interactions of relevant factors. The study found a significant association between higher blood pressure levels and greater EPVS volumes in cognitively normal older people, and this association persisted even after excluding subjects with dementia.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Clinical Neurology
Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya
Summary: Low frequency of social contact is associated with brain atrophy, and depressive symptoms play a role in this relationship.
Article
Geriatrics & Gerontology
Taku Yoshida, Takaaki Mori, Hideaki Shimizu, Ayumi Tachibana, Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Yuki Ozaki, Kentaro Kawabe, Fumie Horiuchi, Kenjiro Komori, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study aimed to identify risk and protective factors for cognitive disorders and found that diabetes mellitus, low activities of daily living, and living alone are risk factors for cognitive decline, while exercise and drinking habits are protective factors.
Article
Geriatrics & Gerontology
Shogyoku Bun, Kouta Suzuki, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Masaru Mimura, JPSC-AD Study Grp
Summary: The association between decreased gait speed and impaired cognitive function was examined, with a focus on the influence of age and gender in the older population. Results showed that reduced gait speed was associated with increased odds of mild cognitive impairment (MCI), and this association may vary according to gender and age.
