Article
Geriatrics & Gerontology
Lisa T. Eyler, Farren B. S. Briggs, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit H. Mulsant, Sigfried Schouws, Nadine P. G. Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Martha Sajatovic
Summary: This study analyzed the symptom mixity in older-age bipolar disorder (OABD) and its association with everyday function. The results showed that mixed features are predominant in OABD and are associated with worse everyday function. Among those with mixed symptoms, the severity of depression is the main driver of poorer functioning.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Martha Sajatovic, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Farren B. S. Briggs, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit Mulsant, Sigfried Schouws, Nadine Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Betsy Wilson, Lisa T. Eyler
Summary: Literature on older-age bipolar disorder (OABD) is limited. This study analyzed data from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) and found that mood symptom severity was low among older individuals, but functioning was mildly impaired and associated with age and education level. Depressive symptoms were strongly linked to worse functioning in older individuals, highlighting the importance of effective treatments for BD depression in this population.
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ioanna Mylona, Georgios D. Floros
Summary: Recent clinical studies suggest that blocking shorter-wavelength blue light may benefit the treatment of bipolar disorder. This critical review aims to evaluate the quality of evidence supporting these claims and explore the underlying neurobiology, while introducing a common set of research criteria for the field.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Xiuhua Song, Yufang Feng, Lei Yi, Baoliang Zhong, Yi Li
Summary: The objective of this case-control study is to determine whether the blood thyroid hormone levels in bipolar disorder patients are associated with different types of first onset. The study found that thyroid dysfunction may be involved in the disease progression of bipolar disorder and correlated with the clinical symptoms in patients with depression or mania as the first episode.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Thomas T. Kim, Jay D. Amsterdam
Summary: This study compared the safety and effectiveness of MAOI therapy in patients with bipolar depression versus unipolar depression. The results showed that patients with bipolar depression had lower post-treatment clinical global impressions/severity scores compared to patients with unipolar depression.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Editorial Material
Biochemistry & Molecular Biology
C. Liu, D. Saffen, T. G. Schulze, M. Burmeister, P. C. Sham, Y-g Yao, P-H Kuo, C. Chen, Y. An, J. Dai, W. Yue, M. X. Li, H. Xue, B. Su, L. Chen, Y. Shi, M. Qiao, T. Liu, K. Xia, R. C. K. Chan
MOLECULAR PSYCHIATRY
(2016)
Article
Biochemistry & Molecular Biology
Jinsong Tang, Yu Fan, Hong Li, Qun Xiang, Deng-Feng Zhang, Zongchang Li, Ying He, Yanhui Liao, Ya Wang, Fan He, Fengyu Zhang, Yin Yao Shugart, Chunyu Liu, Yanqing Tang, Raymond C. K. Chan, Chuan-Yue Wang, Yong-Gang Yao, Xiaogang Chen
JOURNAL OF GENETICS AND GENOMICS
(2017)
Article
Biochemistry & Molecular Biology
Jinchen Li, Lin Wang, Hui Guo, Leisheng Shi, Kun Zhang, Meina Tang, Shanshan Hu, Shanshan Dong, Yanling Liu, Tianyun Wang, Ping Yu, Xin He, Zhengmao Hu, Jinping Zhao, Chunyu Liu, Zhong Sheng Sun, Kun Xia
MOLECULAR PSYCHIATRY
(2017)
Article
Biochemistry & Molecular Biology
Jinchen Li, Shanshan Hu, Kun Zhang, Leisheng Shi, Yi Zhang, Tingting Zhao, Lin Wang, Xin He, Kun Xia, Chunyu Liu, Zhongsheng Sun
MOLECULAR PSYCHIATRY
(2019)
Review
Biochemistry & Molecular Biology
Tanya Horwitz, Katie Lam, Yu Chen, Yan Xia, Chunyu Liu
MOLECULAR PSYCHIATRY
(2019)
Article
Multidisciplinary Sciences
Michael J. Gandal, Jillian R. Haney, Neelroop N. Parikshak, Virpi Leppa, Gokul Ramaswami, Chris Hartl, Andrew J. Schork, Vivek Appadurai, Alfonso Buil, Thomas M. Werge, Chunyu Liu, Kevin P. White, Steve Horvath, Daniel H. Geschwind
Article
Psychiatry
Arisoy Ozden, Halaris Angelos, Aricioglu Feyza, Wild Elizabeth, Piletz John
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Article
Microbiology
Fernando S. Olimpio, Fernando Sa Del Fiol, Renata Lima, Karina S. Rosa, Guilherme A. Roque, Cintia V. Santos, John Piletz
CURRENT MICROBIOLOGY
(2020)
Article
Biochemical Research Methods
Lulu Chen, Chiung-Ting Wu, Chia-Hsiang Lin, Rujia Dai, Chunyu Liu, Robert Clarke, Guoqiang Yu, Jennifer E. Van Eyk, David M. Herrington, Yue Wang
Summary: The study introduces a new deconvolution method called swCAM, which can estimate subtype proportions and subtype-specific (STS) expressions in individual samples from bulk tissue data. The method uses a regularized matrix factorization problem to accurately estimate STS expressions in individual samples and successfully extract co-expression networks in specific subtypes.
Article
Biochemistry & Molecular Biology
Kangli Wang, Rujia Dai, Yan Xia, Jianghua Tian, Chuan Jiao, Tatiana Mikhailova, Chunling Zhang, Chao Chen, Chunyu Liu
Summary: The study showed that DNA methylation and gene expression are coordinated across different human tissues and developmental stages, with correlations being tissue- and development-specific. These correlations are important for cellular functions, complex traits, and human diseases, highlighting the diverse roles of genetic and epigenetic factors in regulating gene expression.
Article
Psychiatry
Qingtuan Meng, Wendiao Zhang, Xuan Wang, Chuan Jiao, Sheng Xu, Chunyu Liu, Beisha Tang, Chao Chen
Summary: This study utilizes hFOs to uncover the connection between VPA exposure and ASD pathogenesis, and finds that VPA affects the expression of genes involved in important pathways such as neural development and synaptic transmission. These findings are valuable for understanding the etiology of ASD and identifying potential therapeutic targets.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Eunice Wm Chin, Qi Ma, Hongyu Ruan, Camille Chin, Aditya Somasundaram, Chunling Zhang, Chunyu Liu, Martin D. Lewis, Melissa White, Tracey L. Smith, Malcolm Battersby, Wei-Dong Yao, Xin-Yun Lu, Wadih Arap, Julio Licinio, Ma-Li Wong
Summary: Synaptic dysfunction is a manifestation of various disorders. This study focuses on the role of PHD finger protein 21B (Phf21b) in synaptic processes and identifies Phf21b as an important regulator of synaptic plasticity-related genes. The Phf21b-deficient mouse model exhibits impaired social memory and reduced expression of synaptic proteins, providing insights into potential therapeutic targets for neurobehavioral dysfunction.
Review
Biochemistry & Molecular Biology
Wendiao Zhang, Jiamei Jiang, Zhenhong Xu, Hongye Yan, Beisha Tang, Chunyu Liu, Chao Chen, Qingtuan Meng
Summary: This review summarizes the methods used to generate microglia-containing human brain organoids (MC-HBOs) and discusses their applications in disease modeling and functional studies.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Wendiao Zhang, Ming Zhang, Zhenhong Xu, Hongye Yan, Huimin Wang, Jiamei Jiang, Juan Wan, Beisha Tang, Chunyu Liu, Chao Chen, Qingtuan Meng
Summary: This study utilized transcriptome-wide association studies and multi-omics analyses to identify the role of PCCB gene in schizophrenia risk through regulating GABAergic pathways.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
John E. Piletz, Jennifer Drivon, John Eisenga, Will Buck, Sabrina Yen, Megan McLin, William Meruvia, Carolina Amaral, Kellie Brue
