Article
Psychiatry
Qian Zhang, Yajie Wan, Xinzhe Du, Yao Gao, Xiao Wang, Kewen Wu, Xiaohu Zheng, Yu Wang, Cheng Zhao, Li Li, Xianju Guo, Xinrong Li, Sha Liu, Yong Xu
Summary: This study explored the relationship between polymorphisms in the NPY gene and antipsychotic drug response in the Chinese population. The results did not find a significant association between the gene polymorphisms and treatment response. This suggests that there may not be a clear relationship between the gene polymorphisms and the efficacy of antipsychotic drugs in patients with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mingming Li, Yuhan Zhang, Aopeng Zhang, He Cai, Rui Zhang, Ran Cheng, Tao Hu
Summary: This study found that single gene polymorphisms in A20 and IL-10 genes were not associated with the risk of periodontitis. NF-kappa B1 gene polymorphism indirectly affects susceptibility to periodontitis. The combined effect of anti-inflammatory gene polymorphisms (A20 and IL-10) correlated with the decreased risk of periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Alessandro Gialluisi, Till F. M. Andlauer, Nazanin Mirza-Schreiber, Kristina Moll, Jessica Becker, Per Hoffmann, Kerstin U. Ludwig, Darina Czamara, Beate St Pourcain, Ferenc Honbolygo, Denes Toth, Valeria Csepe, Guillaume Huguet, Yves Chaix, Stephanie Iannuzzi, Jean-Francois Demonet, Andrew P. Morris, Jacqueline Hulslander, Erik G. Willcutt, John C. DeFries, Richard K. Olson, Shelley D. Smith, Bruce F. Pennington, Anniek Vaessen, Urs Maurer, Heikki Lyytinen, Myriam Peyrard-Janvid, Paavo H. T. Leppanen, Daniel Brandeis, Milene Bonte, John F. Stein, Joel B. Talcott, Fabien Fauchereau, Arndt Wilcke, Holger Kirsten, Bent Mueller, Clyde Francks, Thomas Bourgeron, Anthony P. Monaco, Franck Ramus, Karin Landerl, Juha Kere, Thomas S. Scerri, Silvia Paracchini, Simon E. Fisher, Johannes Schumacher, Markus M. Noethen, Bertram Mueller-Myhsok, Gerd Schulte-Koerne
Summary: This study highlights the significant contribution of common genetic variants to dyslexia risk, as well as novel genomic overlaps with psychiatric conditions like bipolar disorder, schizophrenia, and cross-disorder susceptibility. Additionally, it revealed shared genetic foundations with a neural correlate previously implicated in dyslexia by neuroimaging evidence.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Ya-Ching Chang, Lung-An Hsu, Yu-Lin Ko
Summary: This study investigates the association between PCSK9 E670G polymorphism and Lp(a) levels, and confirms a causal relationship between plasma PCSK9 levels and Lp(a) concentrations through MR analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Guenther Silbernagel, Yan Q. Chen, Martin Rief, Marcus E. Kleber, Michael M. Hoffmann, Tatjana Stojakovic, Andreas Stang, Mark A. Sarzynski, Claude Bouchard, Winfried Maerz, Yue-Wei Qian, Hubert Scharnagl, Robert J. Konrad
Summary: Apolipoprotein C-II (ApoC-II) has an inverse J-shaped relationship with cardiovascular mortality, with the lowest risk observed in the middle quintile. Increasing low circulating ApoC-II levels may reduce cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, Research & Experimental
Jianxin Dong, Miao Wang, Jie Gao, Jie Liu, Yan Chen
Summary: The study found that the expression levels of CGI-58 and LPL in the placenta were significantly lower in patients with preeclampsia compared to the control group, and the lipid levels in these patients were abnormal. The expression of CGI-58 and LPL was associated with the pathogenesis of preeclampsia and maternal lipid levels, with a decrease in expression levels increasing the risk of preeclampsia.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Behavioral Sciences
Przemyslaw Zakowicz, Joanna Pawlak, Pawel Kapelski, Monika Wilkosc-Debczynska, Agnieszka Szalkowska, Joanna Twarowska-Hauser, Janusz Rybakowski, Maria Skibinska
Summary: This study found that cognitive deficits in patients with schizophrenia are associated with genetic variations in the inflammatory response, particularly the functional polymorphisms of the IL10 gene. Recent-onset patients performed better in cognitive tests. These results suggest that the role of cytokines in schizophrenia should be further investigated from the perspective of pro-/anti-inflammatory imbalance.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Yong Wang, Hongwei Chen, Chao Hang, Ying Chen, Jun Gao, Dexin Qiu
Summary: This study investigated the relationship between polymorphism and mRNA expression of the LPL gene with intramuscular fat (IMF) deposition in Baicheng oil chicken (BOC) and Three-yellow Chicken (TYC). The results showed that BOC had higher IMF contents, and the AA genotype was significantly associated with IMF content in TYC's leg muscle. Additionally, mRNA expression of both chest muscle (CM) and leg muscle (LM) was higher in BOC, and there was a positive correlation between CM and LM in both BOC and TYC.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Karla Garay-Garcia, Paula Gaete, Carlos O. Mendivil
Summary: This report presents three cases of severe hypertriglyceridemia in adult patients from Quito, Ecuador, all of which were associated with LMF1 gene variants. Two patients presented with acute pancreatitis, while one patient was asymptomatic but had significantly elevated triglyceride levels. The findings suggest that LMF1 gene may be a common cause of severe hypertriglyceridemia in Latin-American patients.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Neel Mehta, Renald Gilbert, Parminder S. Chahal, Maria J. Moreno, Nasha Nassoury, Nathalie Coulombe, Viktoria Lytvyn, Mario Mercier, Dorothy Fatehi, Wendy Lin, Emily M. Harvey, Lin-Hua Zhang, Nazila Nazemi-Moghaddam, Seyyed Mehdy Elahi, Colin J. D. Ross, Danica B. Stanimirovic, Michael R. Hayden
Summary: This study aimed to develop a more efficacious AAV gene therapy vector for the treatment of LPLD. The researchers identified AAV8 pVR59 as a superior vector compared to AAV1 (Glybera), with significantly better therapeutic effects at lower doses. AAV8 pVR59 treatment led to long-term correction of LPLD and improvement in pathology.
HUMAN GENE THERAPY
(2023)
Article
Multidisciplinary Sciences
Yingli Fu, Xiaojun Ren, Wei Bai, Qiong Yu, Yaoyao Sun, Yaqin Yu, Na Zhou
Summary: This study identified a potential association between CMIP gene variant and schizophrenia risk in the female Han Chinese population, with rs287112 allele frequency showing significant difference in patients compared to healthy controls. The haplotype TTGT of rs12925980-rs2287112-rs3751859-rs77700579 was associated with lower risk of schizophrenia, although not surviving false discovery rate correction.
Article
Genetics & Heredity
Diana Z. Paderina, Anastasiia S. Boiko, Ivan Pozhidaev, Irina A. Mednova, Anastasia A. Goncharova, Anna Bocharova, Olga Yu Fedorenko, Elena G. Kornetova, Arkadiy Semke, Nikolay A. Bokhan, Anton J. M. Loonen, Svetlana A. Ivanova
Summary: The study found that the functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia.
Article
Genetics & Heredity
Khalid Al-Waili, Khalid Al-Rasadi, Muna Al-Bulushi, Mohammed Habais, Abdullah Al-Mujaini, Saif Al-Yaarubi, Antoine Rimbert, Razan Zadjali, Pegah Moradi Khaniabadi, Hamida Al-Barwani, Sana Hasary, Zayana M. Al-Dahmani, Hala Al-Badi, Almundher Al-Maawali, Fahad Zadjali
Summary: This study identified novel genetic mutations in F-HTG patients of Arab ancestry in Oman, suggesting a founder effect and genetic uniqueness in this population. These findings highlight the importance of further analysis and counseling for F-HTG patients in the Middle East, particularly in populations with high rates of consanguinity.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Ryuichi Mashima, Shuji Takada
Summary: This review summarizes the current research progress on Lysosomal Acid Lipase Deficiency (LAL-D), including genetics, screening methods, the tertiary structure of human LAL enzyme, and preclinical studies for the development of new therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Lin Fan, Yiwen You, Yao Fan, Chong Shen, Yong Xue
Summary: The study found a significant association between the ApoA1 gene rs5072 variant and dyslipidemia in schizophrenia patients treated with antipsychotic drugs, potentially increasing susceptibility to lipid metabolism disorders.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Medicine, General & Internal
Lilin Gong, Rong Li, Wei Ren, Zengchan Wang, Zhihong Wang, Maosheng Yang, Suhua Zhang
JOURNAL OF KOREAN MEDICAL SCIENCE
(2017)
Review
Orthopedics
Lun-li Xie, Jun Zhu, Mao-sheng Yang, Chang-yuan Yang, Shun-hong Luo, Yu Xie, Dan Pu
ORTHOPAEDIC SURGERY
(2017)
Review
Urology & Nephrology
Yan Liu, Mao-Sheng Yang, Jian-Yong Yuan
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2013)
Article
Biochemistry & Molecular Biology
Cui Xie, Xiao Feng Liu, Mao Sheng Yang
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Biochemistry & Molecular Biology
Xiao Yun Bao, Bin Peng, Mao Sheng Yang
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Multidisciplinary Sciences
Gui Jv Chen, Mao Sheng Yang
Article
Multidisciplinary Sciences
Xue Li, Mao Sheng Yang
Article
Pediatrics
Shuo Wang, Runmei Zou, Hong Cai, Yuwen Wang, Yiyi Ding, Chuanmei Tan, Maosheng Yang, Fang Li, Cheng Wang
JOURNAL OF PEDIATRICS
(2020)
Article
Oncology
Jingjing Li, Ting Chu, Maosheng Yang
Summary: Oleic acid has effects on the proliferation and migration of vascular smooth muscle cells (VSMCs), possibly through the HGF and p38 MAPK pathways. These findings suggest that oleic acid, HGF, and p38 MAPK may be potential therapeutic targets for atherosclerosis treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Letter
Surgery
Huaqing Wang, Shunhong Luo, Lunli Xie, Maosheng Yang
ASIAN JOURNAL OF SURGERY
(2022)
Article
Medicine, Research & Experimental
Ting Chu, Maosheng Yang
Summary: This article aims to understand and reveal the nature of human disease. It hypothesizes that disease is a form of biodiversity and discusses its implications for medical development and education.
MEDICAL HYPOTHESES
(2022)
Article
Medicine, Research & Experimental
Ting Chu, Maosheng Yang
Summary: The main purpose of this study is to propose a novel approach of cellular transformation for the treatment of human diseases. This hypothesis has the potential to significantly impact disease treatment, medical education, and life science research.
MEDICAL HYPOTHESES
(2022)
Review
Endocrinology & Metabolism
Ting Chu, Mao Sheng Yang
Summary: Roles of different types of adipose tissues in energy metabolism and disease onset have been established. Understanding the biotransformations and molecular mechanisms of white, brown and beige fat cells is crucial for studying pathogenesis and prevention strategies of related diseases.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Medicine, Research & Experimental
Maosheng Yang
Summary: Chromosome abnormalities play a crucial role in diseases, developmental abnormalities, and reproductive medicine. This article proposes a hypothesis called the law of precise matching and assembly chromosomes, which offers valuable insights into genetics, reproduction and development, medicine, species evolution, and can help unravel the molecular mechanisms of chromosome abnormalities. This hypothesis also has the potential to address birth defects, spontaneous abortions, and infertility issues in humans, and can contribute to the revision of genetic and medical textbooks as well as the training of future talent.
MEDICAL HYPOTHESES
(2023)
Article
Medicine, Research & Experimental
Maosheng Yang
Summary: The reproduction and evolution of organisms is an eternal issue worthy of research or exploration. This work proposes oocytes as a promising target for the study of reproductive biology and medicine. The hypothesis suggests that studying oocytes can help reveal their development/maturation process, explain evolutionary differences, develop novel assisted reproductive technologies (ART), and solve human infertility.
MEDICAL HYPOTHESES
(2023)