Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody

Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis

(2010) Judy Young et al.   CYTOKINE

Template Proteogenomics: Sequencing Whole Proteins Using an Imperfect Database

(2010) Natalie E. Castellana et al.   MOLECULAR & CELLULAR PROTEOMICS

Novel therapeutic targets along the Th17 pathway

(2009) Wenjun Ouyang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

(2009) Eugene Y Chiang et al.   NATURE MEDICINE

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

Antibody diversification by somatic mutation: from Burnet onwards

(2008) Michael S Neuberger   IMMUNOLOGY AND CELL BIOLOGY

Automated de novo protein sequencing of monoclonal antibodies

(2008) Nuno Bandeira et al.   NATURE BIOTECHNOLOGY