Journal
PROTEOMICS
Volume 9, Issue 20, Pages 4627-4631Publisher
WILEY-BLACKWELL
DOI: 10.1002/pmic.200900152
Keywords
Algorithm; Candida albicans; MALDI-TOF MS; Microbiology; Proteome profiling; Target for drugs
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MALDI-TOF MS can be used for the identification of microorganism species. We have extended its application to a novel assay of Candida albicans susceptibility to fluconazole, based on monitoring modifications of the proteome of yeast cells grown in the presence of varying drug concentrations. The method was accurate, and reliable, and showed full agreement with the Clinical Laboratory Standards Institute's reference method. This proof-of-concept demonstration highlights the potential for this approach to test other pathogens.
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