Virtual screening on an α-helix to β-strand switchable region of the FGFR2 extracellular domain revealed positive and negative modulators

Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling

(2013) Corentin Herbert et al.   CANCER CELL

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

A Strategy Combining Differential Low-Throughput Screening and Virtual Screening (DLS-VS) Accelerating the Discovery of new Modulators for the Orphan GPR34 Receptor

(2013) Constantino Diaz et al.   Molecular Informatics

The MULTICOM toolbox for protein structure prediction

(2012) Jianlin Cheng et al.   BMC BIOINFORMATICS

An α Helix to β Barrel Domain Switch Transforms the Transcription Factor RfaH into a Translation Factor

(2012) Björn M. Burmann et al.   CELL

Potential and Limitations of Ensemble Docking

(2012) Oliver Korb et al.   Journal of Chemical Information and Modeling

Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models

(2012) J. M. Gozgit et al.   MOLECULAR CANCER THERAPEUTICS

High-resolution structure of infectious prion protein: the final frontier

(2012) Rodrigo Diaz-Espinoza et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutational Tipping Points for Switching Protein Folds and Functions

(2012) Yanan He et al.   STRUCTURE

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

(2012) V. Guagnano et al.   Cancer Discovery

“Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

(2011) Michael R. Wood et al.   BIOCHEMISTRY

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

(2011) Bruce J. Melancon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

(2011) M. Squires et al.   MOLECULAR CANCER THERAPEUTICS

Drug discovery and the human kinome: Recent trends

(2011) Richard Eglen et al.   PHARMACOLOGY & THERAPEUTICS

Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences

(2011) W. J. Anderson et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Protein stability, flexibility and function

(2010) Kaare Teilum et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors

(2010) Anita Büttner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Statistical analysis and molecular dynamics simulations of ambivalent α -helices

(2010) Nicholus Bhattacharjee et al.   BMC BIOINFORMATICS

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain

(2010) Robert OJ Weinzierl   BMC BIOLOGY

GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

(2010) A. Bai et al.   CANCER RESEARCH

Proteins that switch folds

(2010) Philip N Bryan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics

(2010) Masaru Katoh   Expert Review of Anticancer Therapy

The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

(2010) Dene R. Littler et al.   FEBS LETTERS

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

(2010) Albane le Maire et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides

(2010) Malgorzata Broncel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A sequence-based hybrid predictor for identifying conformationally ambivalent regions in proteins

(2009) Yu-Cheng Liu et al.   BMC GENOMICS

Prion Protein Misfolding

(2009) L. Kupfer et al.   CURRENT MOLECULAR MEDICINE

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

A minimal sequence code for switching protein structure and function

(2009) Patrick A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Secondary structure conversions of Mycobacterium tuberculosis ribonucleotide reductase protein R2 under varying pH and temperature conditions

(2008) Elka R. Georgieva et al.   BIOPHYSICAL CHEMISTRY

FGFR2-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival

(2008) K. Kunii et al.   CANCER RESEARCH

The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching

(2008) John J. Skinner et al.   JOURNAL OF CELL BIOLOGY

Improving database enrichment through ensemble docking

(2008) Shashidhar Rao et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A thermodynamic approach to the conformational preferences of the 180-195 segment derived from the human prion protein α2-helix

(2008) Luisa Ronga et al.   JOURNAL OF PEPTIDE SCIENCE

Interconversion between two unrelated protein folds in the lymphotactin native state

(2008) Robbyn L. Tuinstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ordered conformational change in the protein backbone: Prediction of conformationally variable positions from sequence and low-resolution structural data

(2008) Igor B. Kuznetsov   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein Metamorphosis: The Two-State Behavior of Mad2

(2008) Xuelian Luo et al.   STRUCTURE