Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein-Evidence for a common hot spot site at the interface and its functional relevance

Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1

(2013) Yu Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

From prediction to experimental validation: desmoglein 2 is a functionally relevant substrate of matriptase in epithelial cells and their reciprocal relationship is important for cell adhesion

(2012) Vinita Wadhawan et al.   BIOCHEMICAL JOURNAL

The identification of short linear motif-mediated interfaces within the human interactome

(2012) R. J. Weatheritt et al.   BIOINFORMATICS

Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas

(2012) Liang Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD

(2012) Pan Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Structure-based prediction of protein–protein interactions on a genome-wide scale

(2012) Qiangfeng Cliff Zhang et al.   NATURE

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

(2012) Duygu Kuzuoğlu-Öztürk et al.   NUCLEIC ACIDS RESEARCH

Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity

(2012) C Zhen et al.   ONCOGENE

Direct Ubiquitin Independent Recognition and Degradation of a Folded Protein by the Eukaryotic Proteasomes-Origin of Intrinsic Degradation Signals

(2012) Amit Kumar Singh Gautam et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM

(2011) Nurcan Tuncbag et al.   Nature Protocols

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

(2011) D. Cardinale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma

(2011) Wei Wang et al.   TUMOR BIOLOGY

Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer

(2010) Shanhong Tang et al.   CANCER BIOLOGY & THERAPY

Gankyrin promotes the proliferation of human pancreatic cancer

(2010) Yun Meng et al.   CANCER LETTERS

Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

(2010) Jiang-Hong Man et al.   JOURNAL OF CLINICAL INVESTIGATION

Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?

(2010) Nir London et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Assembly, structure, and function of the 26S proteasome

(2010) Lynn Bedford et al.   TRENDS IN CELL BIOLOGY

Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1

(2009) Jian-Wei Wang et al.   CANCER LETTERS

Functional characterization of human oncoprotein gankyrin in Zebrafish

(2009) So Yeon Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Chaperone-mediated pathway of proteasome regulatory particle assembly

(2009) Jeroen Roelofs et al.   NATURE

A Sequence and Structure Based Method to Predict Putative Substrates, Functions and Regulatory Networks of Endo Proteases

(2009) Prasanna Venkatraman et al.   PLoS One

Protein–protein interaction networks: how can a hub protein bind so many different partners?

(2009) Chung-Jung Tsai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human Cancer Protein-Protein Interaction Network: A Structural Perspective

(2009) Gozde Kar et al.   PLoS Computational Biology

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer

(2008) Darinka Todorova Petrova et al.   CLINICAL BIOCHEMISTRY

High confidence determination of specific protein–protein interactions using quantitative mass spectrometry

(2008) Michiel Vermeulen et al.   CURRENT OPINION IN BIOTECHNOLOGY