Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications

Alternatively folded proteins with unexpected beneficial functions: Figure 1

(2012) Soyoung Min et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure and Stability Analysis of Cytotoxic Complex of Camel α-Lactalbumin and Unsaturated Fatty Acids Produced at High Temperature

(2012) Maliheh S. Atri et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Protein–surfactant interactions: A tale of many states

(2011) Daniel Otzen   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cytotoxic complexes of sodium oleate with β-lactoglobulin

(2011) Kamila Lišková et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

The toxicity of bovine α-lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer-derived primary cells

(2011) Christel Rothe Brinkmann et al.   FEBS Journal

Prediction of protein secondary structure from circular dichroism using theoretically derived spectra

(2011) Caroline Louis-Jeune et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

α-Lactalbumin Forms with Oleic Acid a High Molecular Weight Complex Displaying Cytotoxic Activity

(2010) Barbara Spolaore et al.   BIOCHEMISTRY

Protein Chemical Modification on Endogenous Amino Acids

(2010) Emmanuel Baslé et al.   CHEMISTRY & BIOLOGY

Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes

(2010) Ann-Kristin Mossberg et al.   FEBS Journal

Effect of Denaturation of α-Lactalbumin on the Formation of BAMLET (Bovine α-Lactalbumin Made Lethal to Tumor Cells)

(2010) Kamila Lišková et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Interaction of Equine Lysozyme:Oleic Acid Complexes with Lipid Membranes Suggests a Cargo Off-Loading Mechanism

(2010) Søren B. Nielsen et al.   JOURNAL OF MOLECULAR BIOLOGY

Two modes of fatty acid binding to bovine β-lactoglobulin-crystallographic and spectroscopic studies

(2010) Joanna Loch et al.   JOURNAL OF MOLECULAR RECOGNITION

Lipoprotein Complex of Equine Lysozyme with Oleic Acid (ELOA) Interactions with the Plasma Membrane of Live Cells

(2010) Vladana Vukojević et al.   LANGMUIR

BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells

(2010) P. Rammer et al.   MOLECULAR CANCER THERAPEUTICS

The oleic acid complexes of proteolytic fragments of α-lactalbumin display apoptotic activity

(2009) Serena Tolin et al.   FEBS Journal

Protein oligomerization induced by oleic acid at the solid-liquid interface - equine lysozyme cytotoxic complexes

(2009) Kristina Wilhelm et al.   FEBS Journal

α-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding

(2009) Jenny Pettersson-Kastberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Changes in Proteasome Structure and Function Caused by HAMLET in Tumor Cells

(2009) Lotta Gustafsson et al.   PLoS One

Can misfolded proteins be beneficial? The HAMLET case

(2008) Jenny Pettersson-Kastberg et al.   ANNALS OF MEDICINE

Who Is Mr. HAMLET? Interaction of Human α-Lactalbumin with Monomeric Oleic Acid†

(2008) Ekaterina L. Knyazeva et al.   BIOCHEMISTRY

Interaction of fatty acid with myoglobin

(2008) Renuka Sriram et al.   FEBS LETTERS

HAMLET (human α-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death

(2008) Sonja Aits et al.   INTERNATIONAL JOURNAL OF CANCER