Why are polar residues within the membrane core evolutionary conserved?

MPRAP: An accessibility predictor for a-helical transmem-brane proteins that performs well inside and outside the membrane

(2010) Kristoffer Illergård et al.   BMC BIOINFORMATICS

Architecture of helix bundle membrane proteins: An analysis of cytochrome c oxidase from bovine mitochondria

(2010) Erik Wallin et al.   PROTEIN SCIENCE

X-ray structure breakthroughs in the GPCR transmembrane region

(2009) Sid Topiol et al.   BIOCHEMICAL PHARMACOLOGY

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

(2009) Markus Almén et al.   BMC BIOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins

(2009) A. Oberai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OCTOPUS: improving topology prediction by two-track ANN-based preference scores and an extended topological grammar

(2008) Håkan Viklund et al.   BIOINFORMATICS

Structural insights into ABC transporter mechanism

(2008) Michael L Oldham et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Coils in the Membrane Core Are Conserved and Functionally Important

(2008) Anni Kauko et al.   JOURNAL OF MOLECULAR BIOLOGY

Salt-bridge Dynamics Control Substrate-induced Conformational Change in the Membrane Transporter GlpT

(2008) Christopher J. Law et al.   JOURNAL OF MOLECULAR BIOLOGY

Helix dynamics in a membrane transport protein: comparative simulations of the glycerol-3-phosphate transporter and its constituent helices

(2008) Robert S. G. D'rozario et al.   MOLECULAR MEMBRANE BIOLOGY

Prediction of membrane-protein topology from first principles

(2008) A. Bernsel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High tolerance for ionizable residues in the hydrophobic interior of proteins

(2008) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating the length of transmembrane helices using Z-coordinate predictions

(2007) Costas Papaloukas et al.   PROTEIN SCIENCE