Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire

Endocannabinoid Enzyme Engineering: Soluble Human Thio-Monoacylglycerol Lipase (sol-S-hMGL)

(2012) Ioannis Karageorgos et al.   ACS Chemical Neuroscience

Measurements and Implications of the Membrane Dipole Potential

(2012) Liguo Wang   Annual Review of Biochemistry

Monoacylglycerol lipase - a target for drug development?

(2012) CJ Fowler   BRITISH JOURNAL OF PHARMACOLOGY

Hybrid approaches to molecular simulation

(2012) Bosco K Ho et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Drug discovery for a new generation of covalent drugs

(2012) Amit S Kalgutkar et al.   Expert Opinion on Drug Discovery

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

(2012) Sudeshna Ghosh et al.   LIFE SCIENCES

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy

(2011) B. Wesley Trotter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats

(2011) Martin A Sticht et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

(2011) Alpeshkumar K. Malde et al.   Journal of Chemical Theory and Computation

On the Solution Conformation and Dynamics of the HIV-1 Viral Infectivity Factor

(2011) Sean R. Marcsisin et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice

(2011) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of the endocannabinoid system in the neuroendocrine regulation of energy balance

(2011) Francisco Javier Bermudez-Silva et al.   JOURNAL OF PSYCHOPHARMACOLOGY

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

(2011) Natale R. Sciolino et al.   PHARMACOLOGICAL RESEARCH

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

(2011) Céline Schalk-Hihi et al.   PROTEIN SCIENCE

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

(2010) Sean R. Marcsisin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

(2010) Christine M. Hebling et al.   ANALYTICAL CHEMISTRY

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simulating POPC and POPC/POPG Bilayers: Conserved Packing and Altered Surface Reactivity

(2010) Lorant Janosi et al.   Journal of Chemical Theory and Computation

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Solvent-induced lid opening in lipases: A molecular dynamics study

(2010) Sascha Rehm et al.   PROTEIN SCIENCE

The nanodisc: a novel tool for membrane protein studies

(2009) Jonas Borch et al.   BIOLOGICAL CHEMISTRY

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

(2009) Geoffray Labar et al.   CHEMBIOCHEM

Lipid Models for United-Atom Molecular Dynamics Simulations of Proteins

(2009) Andreas Kukol   Journal of Chemical Theory and Computation

Refined homology model of monoacylglycerol lipase: toward a selective inhibitor

(2009) Anna L. Bowman et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structural Basis for Human Monoglyceride Lipase Inhibition

(2009) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

α/βHydrolase Fold: An Update

(2009) David L. Ollis et al.   PROTEIN AND PEPTIDE LETTERS

Lipases at interfaces: A review

(2008) P. Reis et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract

(2008) Marnie Duncan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Covalent Inhibitors of Human Monoacylglycerol Lipase: Ligand-Assisted Characterization of the Catalytic Site by Mass Spectrometry and Mutational Analysis

(2008) Nikolai Zvonok et al.   CHEMISTRY & BIOLOGY

Membrane proteins: molecular dynamics simulations

(2008) E LINDAHL et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Full Mass Spectrometric Characterization of Human Monoacylglycerol Lipase Generated by Large-Scale Expression and Single-Step Purification

(2008) Nikolai Zvonok et al.   JOURNAL OF PROTEOME RESEARCH

The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation

(2007) F Comelli et al.   BRITISH JOURNAL OF PHARMACOLOGY