Converting a protein into a switch for biosensing and functional regulation

Folding-Based Electrochemical Biosensors: The Case for Responsive Nucleic Acid Architectures

(2010) Arica A. Lubin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rational Conversion of Affinity Reagents into Label-Free Sensors for Peptide Motifs by Designed Allostery

(2010) Jin Huang et al.   ACS Chemical Biology

Critical aspects of biointerface design and their impact on biosensor development

(2010) Stella H. North et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure-switching biosensors: inspired by Nature

(2010) Alexis Vallée-Bélisle et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Proteins that switch folds

(2010) Philip N Bryan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure-Based Design of a Photocontrolled DNA Binding Protein

(2010) Stacy-Anne Morgan et al.   JOURNAL OF MOLECULAR BIOLOGY

A photoswitchable DNA-binding protein based on a truncated GCN4-photoactive yellow protein chimera

(2010) Stacy-Anne Morgan et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Engineering an artificial zymogen by alternate frame protein folding

(2010) D. M. Mitrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor

(2010) M. Fosbrink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the mechanism of protein fold-switching by a molecular sensor

(2010) Margaret M. Stratton et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

Exploiting Binding-Induced Changes in Probe Flexibility for the Optimization of Electrochemical Biosensors

(2009) Ryan J. White et al.   ANALYTICAL CHEMISTRY

Structural and Thermodynamic Analysis of a Conformationally Strained Circular Permutant of Barnase†

(2009) James S. Butler et al.   BIOCHEMISTRY

Beyond Molecular Beacons: Optical Sensors Based on the Binding-Induced Folding of Proteins and Polypeptides

(2009) Kenneth J. Oh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Directed evolution: new parts and optimized function

(2009) Michael J Dougherty et al.   CURRENT OPINION IN BIOTECHNOLOGY

Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules

(2009) Shohei Koide   CURRENT OPINION IN BIOTECHNOLOGY

Designing switchable enzymes

(2009) Marc Ostermeier   CURRENT OPINION IN STRUCTURAL BIOLOGY

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bridging the gap: From protein misfolding to protein misfolding diseases

(2009) Leila M. Luheshi et al.   FEBS LETTERS

Structural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface Evolution

(2009) Jin Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct Observation of Tug-of-War during the Folding of a Mutually Exclusive Protein

(2009) Qing Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Semisynthetic Fluorescent Sensor Proteins Based on Self-Labeling Protein Tags

(2009) Matthias A. Brun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational design of ligand binding is not a solved problem

(2009) B. Schreier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors

(2009) A. Vallee-Belisle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Genetically Encoded Biosensors Using Firefly Luciferase

(2008) Frank Fan et al.   ACS Chemical Biology

Design and Characterization of an HIV-Specific Ribonuclease Zymogen

(2008) Rebecca F. Turcotte et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Molecular biosensing system based on intrinsically disordered proteins

(2008) Kyle A. Cissell et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Biosensor technology: Technology push versus market pull

(2008) John H.T. Luong et al.   BIOTECHNOLOGY ADVANCES

Effect of Interdomain Linker Length on an Antagonistic Folding–Unfolding Equilibrium between Two Protein Domains

(2008) Thomas A. Cutler et al.   JOURNAL OF MOLECULAR BIOLOGY

Linking the functions of unrelated proteins using a novel directed evolution domain insertion method

(2008) Wayne R. Edwards et al.   NUCLEIC ACIDS RESEARCH

Design of protein function leaps by directed domain interface evolution

(2008) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genetically encoded fluorescent sensor of ERK activity

(2008) C. D. Harvey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interconversion between two unrelated protein folds in the lymphotactin native state

(2008) Robbyn L. Tuinstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-activated DNA binding in a designed allosteric protein

(2008) D. Strickland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

(2008) C. G. Roessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomolecule Immobilization in Biosensor Development: Tailored Strategies Based on Affinity Interactions

(2008) B. Prieto-Simon et al.   PROTEIN AND PEPTIDE LETTERS

Construction of a fluorescent biosensor family

(2002) Robert M. De Lorimier et al.   PROTEIN SCIENCE