Extension of in vivo half-life of biologically active peptides via chemical conjugation to XTEN protein polymer

A Long-Acting Human Growth Hormone With Delayed Clearance (VRS-317): Results of a Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Growth Hormone–Deficient Adults

(2013) Kevin C. J. Yuen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High Molecular Weight Polyethylene Glycol Cellular Distribution and PEG-associated Cytoplasmic Vacuolation Is Molecular Weight Dependent and Does Not Require Conjugation to Proteins

(2013) Daniel G. Rudmann et al.   TOXICOLOGIC PATHOLOGY

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life

(2012) Jeffrey L. Cleland et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn’s Disease Model

(2012) Susan E. Alters et al.   PLoS One

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

Elucidation of PEGylation site with a combined approach of in-source fragmentation and CID MS/MS

(2010) Xiaojun Lu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Gcg-XTEN: An Improved Glucagon Capable of Preventing Hypoglycemia without Increasing Baseline Blood Glucose

(2010) Nathan C. Geething et al.   PLoS One

PEG-modified biopharmaceuticals

(2009) Pascal Bailon et al.   Expert Opinion on Drug Delivery

Emerging PEGylated drugs

(2009) Jung Seok Kang et al.   EXPERT OPINION ON EMERGING DRUGS

Teduglutide, a novel mucosally active analog of glucagon-like peptide-2 (GLP-2) for the treatment of moderate to severe Crohnʼs disease

(2009) Alan L. Buchman et al.   INFLAMMATORY BOWEL DISEASES

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

(2009) Volker Schellenberger et al.   NATURE BIOTECHNOLOGY

Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates

(2008) Dhanashri Bagal et al.   ANALYTICAL CHEMISTRY

Characterization of Poly(ethylene glycol) and PEGylated Products by LC/MS with Postcolumn Addition of Amines

(2008) Lihua Huang et al.   ANALYTICAL CHEMISTRY

Advances in PEGylation of important biotech molecules: delivery aspects

(2008) Sinéad M Ryan et al.   Expert Opinion on Drug Delivery

The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics

(2008) C.Simone Fishburn   JOURNAL OF PHARMACEUTICAL SCIENCES