Protein engineering methods applied to membrane protein targets

Transmembrane Protein Aptamers That Inhibit CCR5 Expression and HIV Coreceptor Function

(2012) E. H. Scheideman et al.   JOURNAL OF VIROLOGY

Computational Design of Membrane Proteins

(2012) Jose Manuel Perez-Aguilar et al.   STRUCTURE

Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor

(2011) Ethan B. Van Arnam et al.   ACS Chemical Biology

Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations

(2011) Alan Grossfield   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor

(2011) Tanxing Cui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans

(2011) David Salom et al.   FASEB JOURNAL

Evolution of Three Human GPCRs for Higher Expression and Stability

(2011) Igor Dodevski et al.   JOURNAL OF MOLECULAR BIOLOGY

The Scope of Phage Display for Membrane Proteins

(2011) Rosemarie Vithayathil et al.   JOURNAL OF MOLECULAR BIOLOGY

Solubilization of a Membrane Protein by Combinatorial Supercharging

(2010) Agnes Hajduczki et al.   ACS Chemical Biology

Specificity for Homooligomer versus Heterooligomer Formation in Integrin Transmembrane Helices

(2010) Hua Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

De Novo Design and Molecular Assembly of a Transmembrane Diporphyrin-Binding Protein Complex

(2010) Ivan V. Korendovych et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

(2010) Mikhail G Shapiro et al.   NATURE BIOTECHNOLOGY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor

(2010) Tobin J. Cammett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering

(2010) S. A. Marlatt et al.   PROTEIN ENGINEERING DESIGN & SELECTION

X-ray structure breakthroughs in the GPCR transmembrane region

(2009) Sid Topiol et al.   BIOCHEMICAL PHARMACOLOGY

Engineering next generation proteases

(2009) Mark Pogson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor   Receptor

(2009) K. Talbert-Slagle et al.   JOURNAL OF VIROLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Prediction of membrane protein structures with complex topologies using limited constraints

(2009) P. Barth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection and characterization of DARPins specific for the neurotensin receptor 1

(2009) P. Milovnik et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Interaction and conformational dynamics of membrane-spanning protein helices

(2009) Dieter Langosch et al.   PROTEIN SCIENCE

The Single Transmembrane Domains of Human Receptor Tyrosine Kinases Encode Self-Interactions

(2009) C. Finger et al.   Science Signaling

Membrane protein expression: no cells required

(2009) Federico Katzen et al.   TRENDS IN BIOTECHNOLOGY

Computationally Designed Peptide Inhibitors of Protein−Protein Interactions in Membranes†

(2008) Gregory A. Caputo et al.   BIOCHEMISTRY

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

(2008) C. A. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-Protein Interactions in the Membrane: Sequence, Structural, and Biological Motifs

(2008) David T. Moore et al.   STRUCTURE

The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango

(2008) Kristina Talbert-Slagle et al.   VIROLOGY

Heterologous GPCR Expression: A Bottleneck to Obtaining Crystal Structures

(2007) Emily C. McCusker et al.   BIOTECHNOLOGY PROGRESS