Article
Obstetrics & Gynecology
Jordi Ribas-Maynou, Sergi Novo, Albert Salas-Huetos, Sergi Rovira, Marta Antich, Marc Yeste
Summary: This study found that defects in sperm chromatin protamination and condensation can have an impact on ICSI outcomes. Sperm protamination is related to fertilization rates and the in vitro capacity of sperm to condense their chromatin is linked to blastocyst rates, with these associations being more apparent in women.
HUMAN REPRODUCTION
(2023)
Article
Andrology
Riffat Bibi, Sarwat Jahan, Suhail Razak, Mohammad Eid Hammadeh, Ali Almajwal, Houda Amor
Summary: This study aims to identify functional tests in semen that are associated with DNA damage and chromatin maturity, in order to predict outcomes in assisted reproduction. The results suggest that male factor infertility is associated with higher levels of DNA fragmentation and chromatin decondensation in sperm. Additionally, there is a positive correlation between fertilization rate and live birth rate with sperm concentration, motility, vitality, and normal morphology, while there is a negative correlation between sperm DNA fragmentation index and chromatin maturity. However, no correlation was found between embryo aneuploidy and sperm DNA fragmentation or chromatin maturity.
Article
Multidisciplinary Sciences
Yoon Hee Jung, Hsiao-Lin Wang, Daniel Ruiz, Brianna J. Bixler, Hannah Linsenbaum, Jian-Feng Xiang, Samantha Forestier, Andrew M. Shafik, Peng Jin, Victor G. Corces
Summary: This study demonstrates that exposure of pregnant mice to bisphenol A (BPA) can lead to transgenerational transmission of obesity in F2 progeny up to the F6 generation. Chromatin accessibility analysis reveals alterations near binding motifs for CCCTC-binding factor (CTCF) at two cis-regulatory elements of the Fto gene, which correlate with the transmission of obesity. The interaction between these cis-regulatory elements and the Irx3 and Irx5 genes, involved in the differentiation of appetite-controlling neurons, is increased in sperm of obese mice. Deletion of the CTCF site in Fto results in mice that have normal food intake and fail to become obese when ancestrally exposed to BPA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Jonathan Kiwitt-Cardenas, Evdochia Adoamnei, Julian J. Arense-Gonzalo, Laura Sarabia-Cos, Fernando Vela-Soria, Mariana F. Fernandez, Jaime Gosalvez, Jaime Mendiola, Alberto M. Torres-Cantero
Summary: A study conducted with university students in the region of Murcia, Spain, found a significant positive association between urinary BPA concentrations and sperm DNA fragmentation in men with a high SDF index. However, further research is needed to confirm these results and draw conclusions in other male populations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Developmental Biology
Gina Esther Merges, Julia Meier, Simon Schneider, Alexander Kruse, Andreas Christian Frobius, Gregor Kirfel, Klaus Steger, Lena Arevalo, Hubert Schorle
Summary: During spermiogenesis, the expression ratio of protamine 1 (PRM1) and protamine 2 (PRM2) is crucial for fertility. This study generated Prm1-deficient mice using CRISPR-Cas9 gene editing and found that Prm1(+/-) mice had reduced fertility while Prm1(-/-) mice were infertile. Both Prm1(+/-) and Prm1(-/-) mice had high levels of incompletely processed PRM2 in their sperm, leading to DNA damage and increased histone retention.
Article
Genetics & Heredity
Danling Zhu, Zhe Wu
Summary: This study reveals the extensive reprogramming of H3K27me3 and H3K4me3 during Arabidopsis male gametophyte development. It leads to widespread chromatin bivalency and selective removal of H3K27me3 marks from key developmental regulators in sperm.
Review
Endocrinology & Metabolism
Lindsay Moritz, Saher Sue Hammoud
Summary: This article explores the molecular mechanisms underlying male fertility and the process of chromatin remodeling. It points out the current gaps in understanding of the chromatin remodeling process and suggests future research directions to enhance our knowledge of the histone-to-protamine exchange and the etiology of idiopathic male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alberto de la Iglesia, Paula Jauregi, Meritxell Jodar, Ferran Barrachina, Lukas Ded, Carme Mallofre, Leonardo Rodriguez-Carunchio, Juan Manuel Corral, Josep Lluis Ballesca, Katerina Komrskova, Judit Castillo, Rafael Oliva
Summary: The study reveals the dual behavior of H4K5bu and H4K5ac in human spermatogenesis, with both modifications present at different stages of sperm development. These modifications remain stable under different testicular pathologies and are retained in ejaculated sperm. However, no direct association between these modifications and sperm quality was observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Timofey Lebedev, Rubina Kousar, Bbumba Patrick, Muhammad Usama, Meng-Kuei Lee, Ming Tan, Xing-Guo Li
Summary: Epigenetic remodeling and metabolic reprogramming are two highly intertwined cancer hallmarks. Recent studies have shown that the interplay between epigenetic regulation and metabolic rewiring can be targeted as a potential Achilles' heel in cancer. This review explores the immunomodulatory role of ARID1A and summarizes the advances in targeting ARID1A-deficient cancers to improve patient outcome by harnessing the immune-metabolic vulnerability.
Article
Agriculture, Dairy & Animal Science
F. Alfadel, N. Yimer, M. W. H. Hiew
Summary: Bull breeding potential fertility can be predicted by bull breeding soundness evaluation (BBSE), but traditional semen evaluation methods may affect its reliability. This study found that the degree of sperm protamination is correlated with the main parameters of BBSE. Three different methods for protamine assessment showed significant differences among bulls and a negative correlation with semen quality parameters. Among the three tests, AB staining was the cheapest and easiest method, providing an objective assessment of sperm protamination.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Endocrinology & Metabolism
Ruban Dhaliwal, Rocio Pereira, Alicia M. Diaz-Thomas, Camille E. Powe, Licy L. Yanes Cardozo, Joshua J. Joseph
Summary: The Endocrine Society identifies racism as the underlying cause of health disparities affecting racial/ethnic minority communities worldwide. Their policy aims to address this issue by educating and engaging healthcare professionals, researchers, educators, policymakers, and leaders to promote an equitable and diverse healthcare system.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Bruno Garcia Montagnini, Simone Forcato, Karine Vandressa Pernoncine, Mariana Cunha Monteiro, Marina Rangel Ferro Pereira, Nathalia Orlandini Costa, Estefania Gastadello Moreira, Janete Aparecida Anselmo-Franci, Daniela Cristina Ceccatto Gerardin
Summary: The study found that TCS may act as an endocrine disruptor for the reproductive system. Exposure to TCS was shown to decrease sperm viability and motility, potentially related to the programming of reproductive cells during fetal/neonatal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Marc Llavanera, Jordi Ribas-Maynou, Ariadna Delgado-Bermudez, Sandra Recuero, Rodrigo Muino, Carlos O. Hidalgo, Carolina Tamargo, Sergi Bonet, Yentel Mateo-Otero, Marc Yeste
Summary: The study established a flow cytometry method for evaluating chromatin condensation and sperm viability in bulls, and found that CMA3/Yo-Pro-1 staining was more predictive of in vivo fertility compared to conventional sperm parameters. This indicates the potential for improving the efficiency of the dairy breeding industry.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Dalen Zuidema, Karl Kerns, Peter Sutovsky
Summary: Artificial insemination technology plays a crucial role in livestock production worldwide, allowing for rapid genetic improvement. Over the past six decades, continuous improvements have been made in areas such as semen analysis, sperm selection, sexing technologies, and semen storage methods. Future work will focus on refining protocols and increasing pregnancy rates in all livestock species.
Article
Oncology
Aniket Patankar, Rahul Gajbhiye, Suchitra Surve, Priyanka Parte
Summary: The presence of TH2B in mature sperm is intriguing as mature human sperm are transcriptionally and translationally inactive. ChIP-seq analysis revealed the genome-wide localization of TH2B in sperm of fertile men, showing its association with multiple genes and chromosome regions involved in sperm function and embryo development. Altered expression of TH2B associated genes in infertile individuals with sperm chromatin compaction defects suggests a role of TH2B in transcriptional regulation and abnormal nuclear remodeling during spermiogenesis.
CLINICAL EPIGENETICS
(2021)