Article
Oncology
Shauna R. Campbell, Martin C. Tom, Shree Agrawal, Jason A. Efstathiou, Jeff M. Michalski, Matthew C. Abramowitz, Alan Pollack, Daniel E. Spratt, Jason W. D. Hearn, Kevin L. Stephans, Tianming Gao, Jianbo Li, Rahul D. Tendulkar
Summary: PSA kinetics after salvage radiotherapy are strongly associated with the risk of prostate cancer recurrence, providing valuable information for clinical management decisions.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Andrology
Dan Bee Lee, Jae Yeon Kim, Won Hoon Song, Jong Kil Nam, Hyun Jung Lee, Tae Un Kim, Sung-Woo Park
Summary: Persistent levels of PSA after radical prostatectomy are associated with worse metastasis-free survival. In patients with persistent NA levels postoperatively, the %rPSA can be used as a valuable predictor of metastasis, while postoperative fPSA levels do not provide relevant information.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Multidisciplinary Sciences
Xiangyang Yu, Feng Wang, Longjun Yang, Kai Ma, Xiaotong Guo, Lixu Wang, Longde Du, Xin Yu, Shengcheng Lin, Hua Xiao, Zhilin Sui, Lanjun Zhang, Zhentao Yu
Summary: In this study, nomograms were developed to predict disease-free survival (DFS) and overall survival (OS) for patients who underwent pneumonectomy for primary lung cancer. The nomograms showed good discrimination accuracy and clinical utility. They can assist in identifying high-risk patients and developing personalized treatment strategies to improve survival.
Article
Endocrinology & Metabolism
Zhengqing Song, Lisha Cheng, Lili Lu, Weiqi Lu, Yuhong Zhou, Zhiming Wang
Summary: This study aimed to develop and validate practical nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) in synovial sarcoma (SyS) patients. The nomograms demonstrated higher predictive accuracy and clinical value than the AJCC staging system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yiming Shao, Zhonghao Wang, Xiaoya Shi, Yexin Wang
Summary: Currently, there is no established survival prediction model for non-metastatic primary malignant bone tumors of the spine (PMBS) patients. Further exploration of the clinical features and prognostic limitations of PMBS patients is needed.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Michelle S. Chen, Lauren E. Howard, Shannon Stock, Anna Dolgner, Stephen J. Freedland, William Aronson, Martha Terris, Zachary Klaassen, Christopher Kane, Christopher Amling, Matthew Cooperberg, Timothy J. Daskivich
Summary: The study aimed to validate the Prostate Cancer Comorbidity Index (PCCI) score in predicting other-cause mortality (OCM) and cancer outcomes in prostate cancer patients receiving hormone therapy. Through follow-up and assessment of 4857 patients, the study found that higher PCCI scores were associated with increased risk of OCM and worse cancer outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Yuan Zhou, Changming Lin, Lian Zhu, Rentao Zhang, Lei Cheng, Yuanyuan Chang
Summary: This study established predictive models and a scoring system to predict the survival rate of prostate cancer patients. These tools can help clinicians individually assess the survival status of patients and contribute to clinical decisions.
Article
Urology & Nephrology
Patrick-Julien Treacy, Ugo G. Falagario, Francois Magniez, Parita Ratnani, Ethan Wajswol, Alberto Martini, Ivan Jambor, Peter Wiklund, Imad Bentellis, Flora Barthe, Natasha Kyprianou, Matthieu Durand, Daniel Steffens, Sascha Karunaratne, Scott Leslie, Ruban Thanigasalam, Ash Tewari
Summary: This study aimed to evaluate the genomic risk of patients with persistent prostate specific antigen (PSA) using mRNA expression analysis and a validated prognostic genomic-risk classifier. The findings revealed unique genomic features of patients with persistent PSA and confirmed that this condition is associated with a worse prognosis.
MINERVA UROLOGY AND NEPHROLOGY
(2023)
Article
Oncology
Zhen Yang, Guangjun Shi, Ping Zhang
Summary: This study aimed to develop nomograms to predict survival outcomes in patients with pancreatic adenosquamous carcinoma (PASC). Data from the SEER database were analyzed, and prediction models were constructed based on the identified predictors. The nomograms provide a useful tool for calculating individualized survival estimates and assisting in risk stratification and clinical decision-making.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Philipp Mandel, Benedikt Hoeh, Felix Preisser, Mike Wenzel, Clara Humke, Maria-Noemi Welte, Inga Jerrentrup, Jens Koellermann, Peter Wild, Derya Tilki, Alexander Haese, Andreas Becker, Frederik C. Roos, Felix K. H. Chun, Luis A. Kluth
Summary: The study revealed a significant positive correlation between preoperative PSA and tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This finding could help estimate tumor burden before RP and in cases of biochemical recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Qiu Dong, Xiaoting Wu, Wenyi Gan, Tsz Ngai Mok, Juan Shen, Zhengang Zha, Junyuan Chen
Summary: This study establishes two web-based nomograms to estimate the risk and prognosis of bone metastasis (BM) in prostate adenocarcinoma (PA) patients. The nomograms were validated using various analyses and were found to effectively predict risk and prognosis of BM. The study's findings can assist clinicians in optimizing treatment programs and improving patients' prognoses.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Scott A. Greenberg, Samuel L. Washington, Peter E. Lonergan, Janet E. Cowan, Avi S. Baskin, Hao G. Nguyen, Anobel Y. Odisho, Jeffry P. Simko, Peter R. Carroll
Summary: The study found that the presence of benign glandular tissue at the surgical margin after radical prostatectomy was not associated with an increased risk of malignancy at the surgical margin, detectable PSA, biochemical recurrence, or progression after detectable PSA.
JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Fangxu Yin, Song Wang, Chong Hou, Yiyuan Zhang, Zhenlin Yang, Xiaohong Wang
Summary: This study developed two accurate prediction models for survival outcomes in locally advanced breast cancer patients, which were more accurate than conventional TNM staging. These models can guide clinical decision-making and treatment planning for these patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Jianying Yi, Zhili Liu, Lu Wang, Xingxin Zhang, Lili Pi, Chunlei Zhou, Hong Mu
Summary: The study aimed to establish and validate individualized nomograms for predicting overall survival and cancer-specific survival in cervical cancer patients with lymph node metastasis. The results showed that tumor size, log odds of positive lymph nodes, radiotherapy, surgery, T stage, histology, and grade were significant independent predictors for survival. The nomograms exhibited good consistency between predictions and actual observations, with high C-index values. The study concluded that these nomograms can assist clinicians in decision-making and personalized treatment planning.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Peng Wen, Jiao Wen, Xiaolong Huang, Fengze Wang
Summary: This study successfully constructed two nomogram models to predict overall survival (OS) and cancer-specific survival (CSS) of bladder cancer patients, which have clinical significance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ronald de Wit, Stephen J. Freedland, Stephane Oudard, Georgi Marinov, Philippe Capart, Austin J. Combest, Ryan Peterson, Ayse Ozatilgan, Alicia K. Morgans
Summary: This study compared the characteristics and treatment patterns of real-world prostate cancer patients with those of the population in the CARD study, and found that the treatment responses were similar in both populations.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
John M. Masterson, Michael Luu, Aurash Naser-Tavakolian, Stephen J. Freedland, Howard Sandler, Zachary S. Zumsteg, Timothy J. Daskivich
Summary: The number and density of metastatic lymph nodes on lymphadenectomy predict mortality in prostate cancer. The study found that the impact of lymph node density on overall mortality is negligible in patients with 3 or fewer metastatic lymph nodes, who make up the majority of patients with metastatic lymph nodes. Pathological nodal staging should primarily focus on the count of lymph nodes rather than density.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Sanjay Das, Lin Gu, Claire Trustram Eve, Joshua Parrish, Amanda M. De Hoedt, Chad Mckee, William Aronson, Stephen J. Freedland, Stephen B. Williams
Summary: In this study, we evaluated the outcomes of bladder cancer in 378 NMIBC patients and compared the differences between BLC and white light alone. The results showed that BLC significantly reduced the risk of recurrence compared to white light alone, and there was no difference in outcomes between Black and White race.
CLINICAL GENITOURINARY CANCER
(2023)
Letter
Medicine, General & Internal
Farnoosh Nik-Ahd, Amanda De Hoedt, Christi Butler, Jennifer T. Anger, Peter R. Carroll, Matthew R. Cooperberg, Stephen J. Freedland
Summary: This case series examined the frequency of prostate cancer diagnoses in transgender women receiving care at the Veterans Affairs health system.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Farnoosh Nik-Ahd, Justin Waller, Amanda M. DeHoedt, Maurice M. Garcia, Jane C. Figueiredo, Peter R. Carroll, Matthew R. Cooperberg, Stephen J. Freedland
Summary: The study aimed to explore the sensitivity and specificity of five commonly used ICD codes in identifying transgender patients, specifically transgender women, using data from the Veterans Affairs. The results showed that these ICD codes are highly sensitive in identifying transgender patients, and the combination with orchiectomy is extremely sensitive in identifying transgender women.
JOURNAL OF SEXUAL MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Sanjay Das, Jun Gong, Stephen J. Freedland
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Paige K. Kuhlmann, Taofik Oyekunle, Zachary Klaassen, Christopher L. Amling, William J. Aronson, Matthew R. Cooperberg, Christopher J. Kane, Martha K. Terris, Stephen J. Freedland
Summary: This study aimed to provide data support for the choice between active surveillance (AS) and treatment for men with favorable intermediate risk (FIR) prostate cancer. By retrospectively reviewing data from a cohort of men undergoing radical prostatectomy (RP), the theoretical risk of prostate cancer-specific mortality (PCSM) with AS was estimated and compared to RP. The results showed that even with a 1.25x to 2x increased risk of PCSM compared to RP, the risk of death for FIR men choosing AS is still low, up to 15 years.
Article
Biochemical Research Methods
Celina H. Shirazipour, Rachel M. Ruggieri-Bacani, Laura Lockshon, Christopher Waring, Aubrey Jarman, Novalyn Cruz, Catherine Bresee, Angela J. Fong, Pao-Hwa Lin, Gillian Gresham, Arash Asher, Stephen J. Freedland
Summary: This study aims to investigate the feasibility of personalized Zoom-delivered exercise training for breast and prostate cancer survivors, as well as the preliminary efficacy of participation on various health indicators. A 24-week feasibility study will be conducted, involving virtual personal training via Zoom and follow-up exercise using recorded sessions. Physical assessments and surveys will be conducted at multiple time points. Further research is needed to understand the feasibility and effectiveness of virtual exercise programming.
METHODS AND PROTOCOLS
(2023)
Article
Oncology
Xudong Ni, Michael Luu, Weiwei Ma, Tingwei Zhang, Yu Wei, Stephen J. Freedland, Dingwei Ye, Timothy J. Daskivich, Yao Zhu
Summary: Asian males with de novo metastatic prostate cancer have better overall survival and cancer-specific survival compared to white males across different treatment regimens.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Review
Oncology
Neal D. Shore, Judd W. Moul, Kenneth J. Pienta, Johannes Czernin, Martin T. King, Stephen J. Freedland
Summary: Risk stratification is crucial for the management of patients with biochemical recurrence, as it guides the selection of treatment strategies and estimation of adverse events.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Sanjay Das, Nadine A. Friedrich, James Daniels, G. Cecilia Galvan, Jun Gong, Edwin Posadas, William Aronson, Stephen J. Freedland
Summary: This study compares public interest in FDA-approved drugs for advanced prostate cancer and finds that Bicalutamide remains relatively popular, especially among lower-income individuals, those without health insurance, and in states that did not expand Medicaid.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Meeting Abstract
Oncology
Nischal Mahaveer Chand, Poornima K. Tekumalla, Albert Dobi, Amina Ali, Gregory M. Miller, Juan J. Aristizabal-Henao, Elder Granger, Stephen J. Freedland, Shiv Srivastava, Jose Arturo Rodriguez Rivera, Arturo Mendoza, David G. McLeod, Niven R. Narain, Michael A. Kiebish
Meeting Abstract
Oncology
Brandon Noorvash, Carolina Raines, Edwin Melencio Posadas, Howard M. Sandler, Stephen J. Freedland, Gillian Gresham
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Urology & Nephrology
Jun Gong, Daniel M. Kim, Michael R. Freeman, Hyung Kim, Leigh Ellis, Bethany Smith, Dan Theodorescu, Edwin Posadas, Robert Figlin, Neil Bhowmick, Stephen J. Freedland
Summary: Black men with prostate cancer have biologically distinct cancers compared to white men, including genetic alterations, protein differences, and tumor microenvironment. Socioeconomic status partially explains the disparities, but not completely. Further research on these biological differences can guide efforts to improve treatment outcomes for Black men.
NATURE REVIEWS UROLOGY
(2023)
Article
Urology & Nephrology
Stephen J. Freedland, Sandhya Nair, Xiwu Lin, Lawrence Karsh, Christopher Pieczonka, Ravi Potluri, Sabine D. Brookman-May, Suneel D. Mundle, Sarah Fleming, Neeraj Agarwal
Summary: This study evaluated patient characteristics, treatment patterns, and outcomes in men with localized or locally advanced prostate cancer using real-world data.
WORLD JOURNAL OF UROLOGY
(2023)