Article
Biochemistry & Molecular Biology
Chen Xie, Pen-Jen Lin, Jijun Hao
Summary: PDE4D is highly expressed in chemo-resistant prostate cancer cells, and inhibiting PDE4D with Eggmanone effectively reduces invasion, proliferation, and induces cell death in these cells. Eggmanone also enhances docetaxel cytotoxicity and down-regulates CSC marker gene expression, attenuating sphere formation in chemo-resistant prostate cancer cells.
Review
Cell Biology
Morgan Brisset, Patrick Mehlen, Olivier Meurette, Frederic Hollande
Summary: The heterogeneity of cancer cells plays a significant role in therapeutic failure and post-treatment recurrence. Targeting specific subpopulations responsible for chemoresistance and recurrence may improve treatment outcomes in cancer patients. However, the complexity and incomplete understanding of tumor cell subpopulations make it challenging to achieve this.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Fabrizio Fontana, Martina Anselmi, Patrizia Limonta
Summary: It has been found that obesity is associated with a higher risk of prostate cancer. The interaction between adipose tissue and prostate cancer is not fully understood. This study showed that adipocyte conditioned media can induce stemness properties in prostate cancer cells and promote certain gene expressions. Furthermore, exposure to adipocyte conditioned media led to partial epithelial-to-mesenchymal transition in the cancer cells, resulting in enhanced tumor aggressiveness and chemoresistance.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Linxiang Lan, Axel Behrens
Summary: The hierarchy of heterogeneous tumor cell populations, with a small population of cancer stem cells (CSCs) at the top, is explained by the CSC model. These CSCs have the ability to self-renew and generate other cancer cell populations, similar to the function of normal adult stem cells. However, controversies exist regarding the existence and identification of CSCs, which may be attributed to technical differences in experimentation, CSC niche-dependency and plasticity, and CSC heterogeneity itself.
Article
Oncology
Kyosuke Agawa, Kimihiro Yamashita, Akio Nakagawa, Kouta Yamada, Akihiro Watanabe, Junko Mukohyama, Masafumi Saito, Mitsugu Fujita, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
Summary: This study aimed to investigate the relationship between the expression levels of CSC markers in biopsy specimens prior to FP-NAC and the pathological responses in ESCC patients. The results suggest that CD44(high)/CD24(low) expression may serve as an independent predictor of FP-NAC resistance and poor prognosis in ESCC patients.
ANTICANCER RESEARCH
(2021)
Review
Oncology
Giuseppe Bronte, Antonio Domenico Procopio, Laura Graciotti
Summary: The high mortality rate of malignant pleural mesothelioma has led to the study of chemoresistance mechanisms, with the CSC model explaining this phenomenon. Identifying CSCs has potential to lead to new treatment methods.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Cell Biology
Justin W. Magrath, Hong-Jun Kang, Alifiani Hartono, Madelyn Espinosa-Cotton, Romel Somwar, Marc Ladanyi, Nai-Kong Cheung, Sean B. Lee
Summary: This study found that elevated levels of stemness markers are associated with worse survival and metastasis in DSRCT patients. Additionally, they developed the first in vitro DSRCT CSC model, which showed resistance to chemotherapy. These findings provide important tools for further investigation of the DSRCT subpopulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Joanna Radzikowska, Anna M. Czarnecka, Teresa Klepacka, Magdalena Rychlowska-Pruszynska, Anna Raciborska, Bozenna Dembowska-Baginska, Maciej Pronicki, Andrzej Kukwa, Wojciech Fendler, Urszula Smyczynska, Wojciech Kukwa, Antoni Krzeski
Summary: This study aimed to assess the expression and prognostic role of cancer stem cell (CSC) markers in pediatric rhabdomyosarcoma (RMS). The expression of selected CSC markers was confirmed in RMS tissue, but no significant correlation was found with clinical and pathological prognostic factors. Further studies are needed to fully understand the relevance of these CSC markers in RMS carcinogenesis.
Article
Plant Sciences
Yanhua Chen, Qianqian Zhou, Hong Zhang, Linfan Xu, Lianheng Lu, Bing Shu, Lihong Zhou, Fuwen Yuan
Summary: This study aims to explore the anti-tumor role and potential mechanism of Qingdai Decoction (QDT) on prostate cancer. The results showed that QDT can repress cancer growth in advanced prostate cancer models in an androgen receptor independent manner by targeting NOS3, TGFB1, and NCOA2.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Hematology
Jan K. Rudzinski, Natasha P. Govindasamy, Amir Asgari, Max S. Saito, John D. Lewis, Paul Jurasz
Summary: The study found that CD133+/CD44+ and CD133+/CD44-PCSCs have the highest platelet aggregation potency, which may be attributed to their increased prothrombin expression. Platelet-derived SDF-1 alpha stimulates PCSC invasion, and disruption of the SDF-1 alpha:CXCR4 pathway can reduce platelet-induced PCSC invasion.
THROMBOSIS RESEARCH
(2021)
Article
Medicine, Research & Experimental
Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew, Heather M. O'Hagan
Summary: This study reveals the impact of platinum-based chemotherapy on metabolic pathways and identifies key targets that can be therapeutically exploited to inhibit platinum-induced enrichment of OCSCs, ultimately improving the survival of OC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Zhao-liang Yu, Yu-feng Chen, Bin Zheng, Ze-rong Cai, Yi-feng Zou, Jia Ke, Ping Lan, Feng Gao, Xiao-jian
Summary: The study reveals the critical role of TMEM17 in colorectal cancer, showing that TMEM17 depletion can suppress the proliferation of CRC cells and increase sensitivity to chemotherapy drugs. Enrichment analysis indicates that TMEM17 expression is associated with the activation of the Wnt/beta-catenin pathway, and clinical samples show higher TMEM17 expression in tumors is associated with poor survival in CRC patients.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Meghan E. McLean, Maya R. MacLean, Hannah F. Cahill, Raj Pranap Arun, Olivia L. Walker, Marie-Claire D. Wasson, Wasundara Fernando, Jaganathan Venkatesh, Paola Marcato
Summary: This article provides a review of the role of ALDH1A3 in normal physiology, cancer, and other diseases, as well as the potential of targeting ALDH1A3 with non-specific and specific inhibitors.
Article
Medicine, Research & Experimental
Panpan Zhan, Xiong Shu, Meng Chen, Lixin Sun, Long Yu, Jun Liu, Lichao Sun, Zhihua Yang, Yuliang Ran
Summary: This study demonstrates that miR-98 inhibits gastric cancer cell stemness and chemoresistance by targeting BCAT1, indicating that the miR-98/BCAT1 axis may serve as a potential therapeutic target in gastric cancer.
Review
Oncology
Samantha Gogola, Michael Rejzer, Hisham F. F. Bahmad, Ferial Alloush, Yumna Omarzai, Robert Poppiti
Summary: The standard of care therapy for early prostate cancer includes external beam radiation therapy, brachytherapy, radical prostatectomy, active surveillance, or a combination approach. Androgen deprivation therapy is considered for advanced disease. However, many patients eventually develop castration-resistant prostate cancer, leading to the development of targeted therapies, including prostate cancer stem cell-targeted therapies. In this review, the mechanisms of action of PCSC-targeted therapies are summarized and future development is discussed.
Article
Cell Biology
Neslisah Barlak, Ozel Capik, Fatma Sanli, Ahsen Kilic, Abdulmelik Aytatli, Aysenur Yazici, Serkan Ortucu, Michael Ittmann, Omer Faruk Karatas
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Medicine, Research & Experimental
Ahsen Kilic, Neslisah Barlak, Fatma Sanli, Abdulmelik Aytatli, Ozel Capik, Omer F. Karatas
Article
Biochemistry & Molecular Biology
Mehmet Bugrahan Duz, Omer Faruk Karatas
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Chemistry, Medicinal
Derya Anil Aktas, Gokcen Akinalp, Fatma Sanli, Mehmet Ali Yucel, Nicola Gambacorta, Orazio Nicolotti, Omer Faruk Karatas, Oztekin Algul, Serdar Burmaoglu
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Otorhinolaryngology
Omer Faruk Karatas, Ozel Capik, Neslisah Barlak, Elanur Aydin Karatas
Summary: The study identified that the majority of upregulated genes in HNSC are located at chromosome 3q, with DHX36, OPA1, and SENP2 genes potentially being disrupted through mechanisms such as DNA amplification, transcriptional, and posttranscriptional regulation, and may be involved in HNSC carcinogenesis, tumor progression, and induction of angiogenic pathways.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Neslisah Barlak, Ozel Capik, Fatma Sanli, Omer Faruk Karatas
Article
Dentistry, Oral Surgery & Medicine
Rasim Gumus, Ozel Capik, Betul Gundogdu, Arzu Tatar, Konca Altinkaynak, Ozlem Ozdemir Tozlu, Omer Faruk Karatas
Summary: This study found that vitamin D deficiency (VDD) and high cholesterol (HC) co-exist in oral squamous cell carcinoma (OSCC) patients, and their collaboration contributes to tumor formation by modulating glycolysis.
Article
Oncology
Abdulmelik Aytatli, Neslisah Barlak, Fatma Sanli, Hasan Onur Caglar, Betul Gundogdu, Arzu Tatar, Michael Ittmann, Omer Faruk Karatas
Summary: The study showed that the FGFR/Akt/SOX2 axis was overexpressed in tumor tissues compared to normal tissues, and AZD4547 effectively suppressed the expression of FGFR and its downstream targets in recombinant FGF2 treated HNSCC cells. Additionally, AZD4547 reduced the viability, migration, and colony forming capacity of HNSCC cells, with a potentiated impact when co-treated with taxol. This suggests that AZD4547 may be a promising therapeutic agent to overcome taxol-resistance in HNSCC.
Article
Clinical Neurology
Emrah Yurek, Burcu Genc Yavuz, Esra Guzel Tanoglu, Erdem Gurkas, Ibrahim Altundag, Burhanettin Yalcinkaya, Erdal Yilmaz, Sahin Colak
Summary: This study investigated the rate of aspirin resistance (AR) and the factors influencing AR in patients with acute ischemic stroke under regular aspirin use, as well as the relationship between AR and ABCB1 C3435T polymorphism. The study found that 21.3% of the patient group had AR. Hypertension, heterozygous (CT) genotype, increased platelet values, and CRP/albumin values were associated with a greater risk of AR. Considering the ABCB1 C3435T polymorphism is crucial when planning aspirin therapy.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Medicine, General & Internal
Goeksun Demirel, Esra Guzel Tanoglu, Hizir Asliyuksek
Summary: The study aimed to identify a microRNA expression signature for distinguishing methamphetamine from control samples. The results revealed significant overexpression of let-7b-3p in the brain tissues of methamphetamine users, and its potential to discriminate methamphetamine from control samples.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Article
Urology & Nephrology
Altundag Ibrahim, Guzel Tanoglu Esra, Genc Yavuz Burcu, Yalcinkaya Burhanettin, Yurek Emrah, Colak Sahin
Summary: This study investigated the relationship between ALPL gene polymorphism and urolithiasis in the Turkish population. Male gender, increased BUN level, increased NLR level, and heterozygous genotype were identified as independent risk factors for the development of urolithiasis.
Article
Biology
Esra Guzel Tanoglu, Yavuz Arikan, Yavuz Selim Kabukcuoglu, Fevziye Kabukcuoglu, Alpaslan Tanoglu, Sukru Ozturk
Summary: The study revealed that miR-129-2-3p is downregulated in Ewing sarcoma, leading to inhibition of tumor growth and migration. Target genes CDK6 and SOX4 were also found to be downregulated along with miR-129-2-3p.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Esra Guzel Tanoglu, Alpaslan Tanoglu, Makbule Cisel Aydin Mericoz, Muhammed Fevzi Esen
Summary: The study showed that melatonin has positive effects on an experimental rat CP model, including alleviating ER stress, oxidative stress, fibrosis, and improving biochemical parameters and histopathological features. Moreover, melatonin can reduce the expression levels of specific genes associated with CP.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Burhanettin Yalcinkaya, Esra Guzel Tanoglu, Didem Tastekin, Sadrettin Pence
Summary: HCC patients showed downregulated expression levels of miR-33a, miR-203b, and miR-361-3p, implicating their potential involvement in tumor pathogenesis and suggesting their utility as noninvasive biomarkers for cancer therapy.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
E. Guzel Tanoglu, S. Ozturk
Summary: The study demonstrated that down-regulation of miR-145 inhibits the EMT process in EWS cells by targeting stem cell properties, leading to the inhibition of tumor growth and metastasis in TC71 and TC106 cells. MiR-145 overexpression resulted in proliferation inhibition, reduced migration, and suppression of EMT capacity and SOX2, KLF4, and OCT4 expression levels in EWS cells.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2021)