The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn2+-chelation and inhibiting the serine protease Omi/HtrA2

Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors

(2013) William H. Gmeiner et al.   JOURNAL OF NEURO-ONCOLOGY

Zinc transporters in prostate cancer

(2013) M.-C. Franz et al.   MOLECULAR ASPECTS OF MEDICINE

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

(2012) T. S. Pardee et al.   BLOOD

Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity

(2012) Jamie Jennings-Gee et al.   EXPERIMENTAL HEMATOLOGY

Reaction of Metal-Binding Ligands with the Zinc Proteome: Zinc Sensors and N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine

(2012) Jeffrey W. Meeusen et al.   INORGANIC CHEMISTRY

Imaging free zinc levels in vivo – What can be learned?

(2012) Luis De Leon-Rodriguez et al.   INORGANICA CHIMICA ACTA

Cooperative stabilization of Zn2+:DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA

(2012) Supratim Ghosh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Novel Polypyridyl chelators deplete cellular zinc and destabilize the X-linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells

(2012) Jian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary zinc and prostate cancer survival in a Swedish cohort

(2011) M. M. Epstein et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma

(2011) Leslie C. Costello et al.   CANCER BIOLOGY & THERAPY

Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif

(2011) Supratim Ghosh et al.   NUCLEIC ACIDS RESEARCH

Prostate cancer outcome and tissue levels of metal ions

(2011) Andrey G. Sarafanov et al.   PROSTATE

Docetaxel-mediated apoptosis in myeloid progenitor TF-1 cells is mitigated by zinc: Potential implication for prostate cancer therapy

(2011) Peter Makhov et al.   PROSTATE

Zinc is decreased in prostate cancer: an established relationship of prostate cancer!

(2010) Leslie C. Costello et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Dietary Zinc and Prostate Cancer in the TRAMP Mouse Model

(2010) Ananda S. Prasad et al.   JOURNAL OF MEDICINAL FOOD

Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell-Line Screen and Comparison of FdUMP[10] with Fluorouracil, Floxuridine, and Topoisomerase 1 Poisons

(2010) W. H. Gmeiner et al.   MOLECULAR CANCER THERAPEUTICS

Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer

(2009) Maulik R Shah et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

(2009) Quinn P. Peterson et al.   JOURNAL OF MOLECULAR BIOLOGY

Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis

(2008) P Makhov et al.   CELL DEATH AND DIFFERENTIATION