PDE5 inhibitors blunt inflammation in human BPH: A potential mechanism of action for PDE5 inhibitors in LUTS

A Systematic Review and Meta-analysis on the Use of Phosphodiesterase 5 Inhibitors Alone or in Combination with α-Blockers for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia

(2012) Mauro Gacci et al.   EUROPEAN UROLOGY

The Mechanism of Action of Phosphodiesterase Type 5 Inhibitors in the Treatment of Lower Urinary Tract Symptoms Related to Benign Prostatic Hyperplasia

(2012) François Giuliano et al.   EUROPEAN UROLOGY

Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells

(2012) Linda Vignozzi et al.   JOURNAL OF ENDOCRINOLOGY

Testosterone/Estradiol Ratio Regulates NO‐Induced Bladder Relaxation and Responsiveness to PDE5 Inhibitors

(2012) Linda Vignozzi et al.   Journal of Sexual Medicine

A Randomized, Placebo-Controlled Study to Assess Safety and Efficacy of Vardenafil 10 mg and Tamsulosin 0.4 mg vs. Tamsulosin 0.4 mg Alone in the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

(2012) Mauro Gacci et al.   Journal of Sexual Medicine

Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome

(2012) Annamaria Morelli et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Response of the Prostate to Circulating Cholesterol: Activating Transcription Factor 3 (ATF3) as a Prominent Node in a Cholesterol-Sensing Network

(2012) Jayoung Kim et al.   PLoS One

Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation

(2012) Linda Vignozzi et al.   PROSTATE

Mechanism of action of phosphodiesterase type 5 inhibition in metabolic syndrome-associated prostate alterations: An experimental study in the rabbit

(2012) Annamaria Morelli et al.   PROSTATE

Metabolic syndrome and lower urinary tract symptoms: the role of inflammation

(2012) M Gacci et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury

(2011) Otgonchimeg Rentsendorj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17β-estradiol and insulin-like growth factor 1

(2011) Dawei Zhou et al.   CELL BIOCHEMISTRY AND FUNCTION

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia

(2011) S. Z. Lutz et al.   DIABETES

Critical Analysis of the Relationship Between Sexual Dysfunctions and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia

(2011) Mauro Gacci et al.   EUROPEAN UROLOGY

The Correlation Between Metabolic Syndrome and Prostatic Diseases

(2011) Cosimo De Nunzio et al.   EUROPEAN UROLOGY

Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit

(2011) Linda Vignozzi et al.   JOURNAL OF ENDOCRINOLOGY

Phosphodiesterase Type 5 Expression in Human and Rat Lower Urinary Tract Tissues and the Effect of Tadalafil on Prostate Gland Oxygenation in Spontaneously Hypertensive Rats

(2011) Annamaria Morelli et al.   Journal of Sexual Medicine

Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: Pathophysiology and mechanism(s) of action

(2011) Karl-Erik Andersson et al.   NEUROUROLOGY AND URODYNAMICS

Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism

(2011) Con Mallidis et al.   REPRODUCTION

Phosphodiesterase-5 Inhibitors for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis

(2011) Liangren Liu et al.   UROLOGY

Farnesoid X receptor activation improves erectile dysfunction in models of metabolic syndrome and diabetes

(2010) Annamaria Morelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin-resistance and benign prostatic hyperplasia: The connection

(2010) Ajit Vikram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vardenafil Decreases Bladder Afferent Nerve Activity in Unanesthetized, Decerebrate, Spinal Cord–Injured Rats

(2010) Delphine Behr-Roussel et al.   EUROPEAN UROLOGY

Different effects of soluble and particulate guanylyl cyclases on expression of inflammatory cytokines in rat peripheral blood mononuclear cells

(2010) Małgorzata Mitkiewicz et al.   IMMUNOBIOLOGY

Farnesoid X Receptor Activation Improves Erectile Function in Animal Models of Metabolic Syndrome and Diabetes

(2010) Linda Vignozzi et al.   Journal of Sexual Medicine

Ezetimibe Reduces Enlarged Prostate in an Animal Model of Benign Prostatic Hyperplasia

(2010) Kristine Pelton et al.   JOURNAL OF UROLOGY

Effects of Phosphodiesterase Inhibitors on the Inflammatory Response of Endothelial Cells Stimulated by Myeloperoxidase-Modified Low-Density Lipoprotein or Tumor Necrosis Factor Alpha

(2009) Thierry Roumeguère et al.   EUROPEAN UROLOGY

Chronic inflammation in the pathogenesis of benign prostatic hyperplasia

(2009) B. Fibbi et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Human Benign Prostatic Hyperplasia Stromal Cells As Inducers and Targets of Chronic Immuno-Mediated Inflammation

(2009) G. Penna et al.   JOURNAL OF IMMUNOLOGY

Testosterone Partially Ameliorates Metabolic Profile and Erectile Responsiveness to PDE5 Inhibitors in an Animal Model of Male Metabolic Syndrome

(2009) Sandra Filippi et al.   Journal of Sexual Medicine

Vardenafil Modulates Bladder Contractility Through cGMP-mediated Inhibition of RhoA/Rho Kinase Signaling Pathway in Spontaneously Hypertensive Rats

(2009) Annamaria Morelli et al.   Journal of Sexual Medicine

Acute Vardenafil Administration Improves Bladder Oxygenation in Spontaneously Hypertensive Rats

(2009) Annamaria Morelli et al.   Journal of Sexual Medicine

Increased cell proliferation and contractility of prostate in insulin resistant rats: Linking hyperinsulinemia with benign prostate hyperplasia

(2009) A. Vikram et al.   PROSTATE